Variation in stable carbon (δC) and nitrogen (δN) isotope compositions along antlers of Qamanirjuaq caribou ().

Annual antler growth begins in the spring and is completed by late summer for male caribou () from the Qamanirjuaq herd (Nunavut, Canada), aligned with both the spring migration and a seasonal dietary shift. Antlers may provide a non-lethal means of studying short- and long-term changes in caribou ecology through incorporated isotopes of carbon (δC) and nitrogen (δN). We sampled the antlers of 12 male caribou from the Qamanirjuaq herd culled in September 1967.

Comparative histopathological analysis of age-associated intervertebral disc degeneration in CD-1 and C57BL/6 mice: Anatomical and sex-based differences.

Background: Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease-modifying treatments. Mouse models are commonly used to study IVD degeneration; however, the effects of anatomical location, strain, and sex on the progression of age-associated degeneration are poorly understood.

A perspective on the initiative to develop a multi-species histopathology series.

This perspective summarizes the genesis, development, and potential future directions of the multispecies histopathology series.

Lineage tracing of Foxd1-expressing embryonic progenitors to assess the role of divergent embryonic lineages on adult dermal fibroblast function.

Recent studies have highlighted the functional diversity of dermal fibroblast populations in health and disease, with part of this diversity linked to fibroblast lineage and embryonic origin. Fibroblasts derived from -expressing progenitors contribute to the myofibroblast populations present in lung and kidney fibrosis in mice but have not been investigated in the context of dermal wound repair. Using a Cre/Lox system to genetically track populations derived from -expressing progenitors, lineage-positive fibroblasts were identified as a subset of the dermal fibroblast population.

Floods and the COVID-19 pandemic-A new double hazard problem.

The coincidence of floods and coronavirus disease 2019 (COVID-19) is a genuine multihazard problem. Since the beginning of 2020, many regions around the World have been experiencing this double hazard of serious flooding and the pandemic. There have been 70 countries with flood events occurring after detection of the country's first COVID-19 case and hundreds of thousands of people have been evacuated.

The mechano-response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent.

The intervertebral disk (IVD) is a composite structure essential for spine stabilization, load bearing, and movement. Biomechanical factors are important contributors to the IVD microenvironment regulating joint homeostasis; however, the cell type-specific effectors of mechanotransduction in the IVD are not fully understood. The current study aimed to determine the effects of cyclic tensile strain (CTS) on annulus fibrosus (AF) cells and identify mechano-sensitive pathways.

Vascularization of the human intervertebral disc: A scoping review.

Intervertebral discs (IVDs) are often referred to as the largest avascular structures of the human body, yet a collective resource characterizing the vascularization of the IVD does not exist. To address this gap, the objective of this study was to conduct a comprehensive search of the literature to review and summarize current knowledge of the prevalence and localization of blood supply in human IVDs, with a scoping review. A comprehensive search of peer-reviewed publications on the topic of IVD vascularization in humans was conducted across six electronic databases: PubMed, EMBASE, MEDLINE, Scopus, Web of Science, and BIOSIS Previews.

Protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc tissues.

The comprehensiveness of data collected by "omics" modalities has demonstrated the ability to drastically transform our understanding of the molecular mechanisms of chronic, complex diseases such as musculoskeletal pathologies, how biomarkers are identified, and how therapeutic targets are developed. Standardization of protocols will enable comparisons between findings reported by multiple research groups and move the application of these technologies forward. Herein, we describe a protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc (IVD) tissues, building from the combined expertise of our collaborative team.

Subjective cognitive and non-cognitive complaints and brain MRI biomarkers in the MEMENTO cohort.

Introduction: Subjective cognitive complaints may be a signature of preclinical stage Alzheimer's disease. However, the link between subjective cognitive and non-cognitive complaints and brain alterations remains unclear.

Methods: The relationship between cognitive and non-cognitive complaints and brain biomarkers, measured by structural magnetic resonance imaging, was investigated in 2056 participants of the MEMENTO cohort of outpatients, who were dementia-free at baseline.

Mallard resource selection trade-offs in a heterogeneous environment during autumn and winter.

Animals select resources to maximize fitness but associated costs and benefits are spatially and temporally variable. Differences in wetland management influence resource availability for ducks and mortality risk from duck hunting. The local distribution of the Mallard () is affected by this resource heterogeneity and variable risk from hunting.

Dentine oxygen isotopes (δ (18)O) as a proxy for odontocete distributions and movements.

Spatial variation in marine oxygen isotope ratios (δ (18)O) resulting from differential evaporation rates and precipitation inputs is potentially useful for characterizing marine mammal distributions and tracking movements across δ (18)O gradients. Dentine hydroxyapatite contains carbonate and phosphate that precipitate in oxygen isotopic equilibrium with body water, which in odontocetes closely tracks the isotopic composition of ambient water. To test whether dentine oxygen isotope composition reliably records that of ambient water and can therefore serve as a proxy for odontocete distribution and movement patterns, we measured δ (18)O values of dentine structural carbonate (δ (18) OSC) and phosphate (δ (18) OP) of seven odontocete species (n = 55 individuals) from regional marine water bodies spanning a surface water δ (18)O range of several per mil.