Evidence-Informed Nursing Clinical Practices for Wound Debridement.

Debridement, a mainstay of nursing clinical practice, refers to the removal of dead or unhealthy tissue from a wound to facilitate healing. Debridement is one component of the concept of wound bed preparation that has long guided the approach to wound management. The ability of a wound to heal must be determined prior to the initiation of any method of debridement.

From Comic-Con to Amazon: Fan conventions and digital platforms.

San Diego Comic-Con is North America's premiere fan convention and a key site for mediating between media industries and fandom. In 2020, the COVID-19 pandemic forced Comic-Con to abruptly move its programming onto an array of digital platforms in an apparent "platformization" of the con. Informed by research on fan conventions, media industries, and the platformization of cultural production, this analysis of the online convention argues that Comic-Con was primed for platformization because it is already platform-like.

Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children.

Background: Hemagglutinin (HA)-inhibiting antibodies contribute to the immune defense against influenza infection. However, there are insufficient data on the extent of correlation between vaccine-elicited HA antibodies and protection in children against different influenza strains, particularly when comparing live attenuated influenza vaccines (LAIV) versus inactivated influenza vaccines (IIV).

Methods: We measured postvaccination hemagglutination-inhibition (HAI) titers in 3-15-year-old participants of a cluster-randomized controlled trial of trivalent LAIV(3) versus IIV(3) in Canadian Hutterite colonies.

Radiation Reduction in Paediatric Cardiac Catheterization: We Can Go Even Lower.

Background: Radiation reduction is an integral component in the management of a paediatric cardiac catheterization laboratory. Simple and easily implementable protocol changes and technical upgrades have been shown to significantly reduce radiation exposure.

Methods: Radiation exposures (2020-2022) at Safra Children's Hospital, Sheba Medical Center, Israel (unit A: n = 672) were retrospectively reviewed, including dose area product (DAP) (μGy m), DAP/kg, Air Kerma (mGy), and fluoroscopy time (minutes) for 16 procedural types.

Building and Sustaining Aging in Place Through the Naturally Occurring Retirement Community (NORC) Ambassadors Program.

Older adults overwhelmingly want to continue to age in place but would benefit from a community of support to do so. The Naturally Occurring Retirement Community (NORC) Ambassadors program - an initiative from University Health Network (UHN) OpenLab - uses a participatory approach to create sustainable, resident-led, aging-in-place groups in NORC buildings. NORC, which stands for Naturally Occurring Retirement Community, is a geographic designation used to describe an area, such as a building or a neighbourhood that has become home to a large number of older adults.

Health Quality 5.0: What Does Co-Creation Have to Do With It?

In this latest article in Leslee Thompson's Health Quality 5.0 series, she discusses the slow progress of patient engagement in healthcare over the past two decades, emphasizing the need for co-creation where patients and providers collaborate equally. It explores the challenges of overcoming traditional power dynamics and integrating patient knowledge into healthcare systems.

Introduction: Why a Special Focus on Mental Health and Substance Use?

Mental health and substance use have a long history of recurring cycles of reform across the globe. These reforms are often driven more by shifts in economic conditions, social ideologies, political climates and technological advancements than by design from within the fractionated mental health sector. Progress has been hindered by difficulty in fully conceptualizing the complex, multi-faceted nature of these issues, as well as by stigma, insufficient research and a lack of information.

Observing Healthcare With Mary in Her Final Weeks of Life.

Early in the year 2024, my mother, Mary V. Seeman (MD, DSc, OC, FRCPC), received news that would recognize her lifelong goal, which was to humanize and empower some of the most stigmatized members of society - the severely mentally ill and their parents and, in particular, their mothers. The American Psychiatric Association had chosen to honour her with the 2024 Adolf Meyer Lifetime Achievement Award, a prestigious tribute to her life's work in improving women's mental health.

Data-Driven Insights and Solutions for the Health and Human Resource Crisis in Canada.

Canada's healthcare system is experiencing a health and human resource (HHR) crisis. The available evidence of the scope of the problem and potential solutions, however, is not commensurate with the scale and urgency of the crisis. The use of linked health administrative data to study the health, well-being and work patterns of the health workforce offers critical insights into how the workforce is functioning at a population level.

CNS macrophage contributions to myelin health.

Myelin is the membrane surrounding neuronal axons in the central nervous system (CNS), produced by oligodendrocytes to provide insulation for electrical impulse conduction and trophic/metabolic support. CNS dysfunction occurs following poor development of myelin in infancy, myelin damage in neurological diseases, and impaired regeneration of myelin with disease progression in aging. The lack of approved therapies aimed at supporting myelin health highlights the critical need to identify the cellular and molecular influences on oligodendrocytes.

Vesicle Picker: A tool for efficient identification of membrane protein complexes in vesicles.

Electron cryomicroscopy (cryo-EM) has recently allowed determination of near-atomic resolution structures of membrane proteins and protein complexes embedded in lipid vesicles. However, particle selection from electron micrographs of these vesicles can be challenging due to the strong signal contributed from the lipid bilayer. This challenge often requires iterative and laborious particle selection workflows to generate a dataset of high-quality particle images for subsequent analysis.

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.

Background: Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among persons with obesity has not been well studied.

Methods: We conducted a 68-week, double-blind, randomized, placebo-controlled trial at 61 sites in 11 countries.

Proton Therapy in Uveal Melanoma.

Uveal melanoma is the most common primary intraocular malignancy in adults. Treatment options for localized, early-stage disease include enucleation, brachytherapy, and proton beam therapy. This review aims to evaluate the role of proton therapy in the definitive management of uveal melanoma, focusing on its physics, radiobiology, treatment techniques, and associated outcomes.

EuDockScore: Euclidean graph neural networks for scoring protein-protein interfaces.

Motivation: Protein-protein interactions are essential for a variety of biological phenomena including mediating biochemical reactions, cell signaling, and the immune response. Proteins seek to form interfaces which reduce overall system energy. Although determination of single polypeptide chain protein structures has been revolutionized by deep learning techniques, complex prediction has still not been perfected.

Respiratory hospitalizations and ICU admissions among children with and without medical complexity at the end of the COVID-19 pandemic.

Decreased severe respiratory illness was observed during the first 2 years of the COVID-19 pandemic, with a relatively smaller decrease among children with medical complexity (CMC) compared to non-CMC. We extended this analysis to the third pandemic year (April 1, 2022, to March 31, 2023) when pandemic public health measures were loosened. A population-based repeated cross-sectional study evaluated respiratory hospitalizations among CMC and non-CMC (<18 years) in Ontario, Canada.

Comprehensive Next Generation Sequencing Reveals that Purported Primary Squamous Cell Carcinomas of the Parotid Gland are Genetically Heterogeneous.

Squamous cell carcinoma (SCC) is one of the most common malignancies involving the parotid gland, but it has been recognized that the vast majority of parotid SCC represents metastases, especially from the ipsilateral facial skin. Bona fide primary SCC of the parotid is so rare that it is unclear whether it truly exists at all. We sought to molecularly characterize cases diagnosed as primary parotid gland SCC to see if they possess a unique genetic makeup.

Toward a universal definition of provider-patient attachment in primary care.

Objective: To explore definitions of provider-patient attachment in primary care (PC) and help inform a universal definition of provider-patient attachment.

Data Sources: Comprehensive searches were conducted using the electronic databases MEDLINE (Ovid), PubMed, CINAHL (EBSCO), PsycInfo (Ovid), Social Sciences Abstracts (EBSCO), Cochrane Library, Scopus, Embase (Ovid), Google Scholar, and ResearchGate.

Study Selection: A scoping review was conducted.