Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.

In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.

Perceived usability and acceptability of the My-Hip Fracture risk communication tool from the perspective of academic clinicians.

Objective: We evaluated the usability and acceptability of My-Hip Fracture (My-HF), a web application that assists providers in delivering individualized prognostic information to patients hospitalized for hip fracture (HF).

Methods: We observed a sample of 16 clinicians as they navigated My-HF. We then administered a structured questionnaire and conducted semi-structured interviews to explore participants' opinions about the app's content and the feasibility of incorporating the app into clinical workflows.

An Integrated Rapid Response Model for Pediatric Patients Requiring In-Patient Medical Stabilization: Lessons Learned to Enable Regional Capacity Building.

There was an unprecedented surge in admissions for medical stabilization of pediatric patients with eating disorders during the COVID-19 pandemic in Ontario. Eleven hospitals established an integrated rapid response model to ensure timely in-patient access for these patients. This population was cared for in re-allocated community hospital beds as a result of engaging hospital leadership, strengthening partnerships, consulting experts, leveraging existing resources and developing regional bed access strategies.

Co-Creating a Vision for the Future of Healthcare Leadership: An Organizational Case Study.

This qualitative case study explores the perspectives of approximately 270 leaders at all levels within Canada's largest community hospital to identify the qualities of effective leaders and their aspirations for the future of healthcare leadership. Responses to a structured visioning exercise with three open-ended prompts were anonymously collected, sorted using ChatGPT and thematically analyzed. Connection, integrity and impact were identified as central to effective leadership.

Exploring Quality and Safety Best Practices at Leading International Centres.

Background: This project aimed to go beyond published literature to glean strategies and lessons learned on quality and safety (Q&S) best practices from centres with pre-eminent international reputations.

Methods: Nine centres participated in an interview; questions centred on approaches to building Q&S infrastructure around the Institute for Healthcare Improvement's (IHI's) Whole System Quality (WSQ) framework (Sampath et al. 2021).

Introduction to Mental Health in Healthcare Workplaces.

In the quest by health leaders to create the conditions necessary for the delivery of safe, high-quality care, this issue of () is pleased to offer some promising approaches and resources for establishing healthy workplaces. We are all too aware that the workforce - as the backbone of the health system - is facing severe pressures. The demand for healthcare workers is outpacing supply, which necessitates innovative solutions to retain those already in the system.

The Siren Call for Business Model Innovation in Healthcare.

This essay explores the necessity and return on investment for business model innovation in Canada's healthcare system, questioning the traditional approach of rapid product development. It highlights the pressing need for innovative solutions to address the challenges posed by an aging population, with one-third of Canadians over 65 years of age managing multiple chronic conditions (Statistics Canada 2024). The discussion aims to redefine healthcare innovation strategies to enhance healthcare delivery and sustainability.

Lung Cancer and COPD: Opportunities to Leverage Lung Cancer Screening Programs to Improve COPD Diagnostics.

Lung cancer and chronic obstructive pulmonary disease (COPD) have many shared risk factors and not surprisingly, the two diseases often coexist. This article highlights the burden of COPD among patients with lung cancer in Ontario and explores opportunities to enhance lung cancer screening programs. We propose pursuing integrated strategies that incorporate new advances in artificial intelligence to improve disease diagnostics and navigate the complexity of caring for people with coexisting lung diseases.

Perceived barriers and facilitators of implementing a sustained smartphone-based telemonitoring program for pregnant women at high-risk for pre-eclampsia in the public and private sectors in Pakistan.

Background: In Pakistan, a smartphone-based telemonitoring (TM) program (Raabta) has been designed to support pregnant women with high risk for preeclampsia (HRPE) in Pakistan. However, implementing TM interventions is often challenging, particularly in low-resource settings, given the complexity of healthcare environments and variations in public and private health sectors. This study explores the potential barriers and facilitators for a sustained implementation of the Raabta program in public and private sector hospitals in Pakistan.

Stimulus conditions that promote habitual control.

Two experiments in rats examined how training where a stimulus signaled when to respond for reward, conditions that should favour S-R learning, might lead to habitual control of behaviour. Experiment 1 investigated how animals trained with a stimulus preceding lever insertion would impact learning relative to a group that was self-paced and could control lever insertion with a second, distinct response. Rats were then tested for sensitivity to outcome devaluation to distinguish between goal-directed and habitual control.

Treat-to-Target Outcomes With Tapinarof Cream 1% in Phase 3 Trials for Plaque Psoriasis.

The National Psoriasis Foundation (NPF) treatment targets aim to achieve 1% or lower body surface area (BSA) affected after 3 months of treatment. European psoriasis treatment guidelines aim to achieve similar goals based on improvements in Psoriasis Area and Severity Index (PASI) scores. We performed pooled analyses of the PSOARING phase 3 program, which evaluated treat-to-target outcomes for patients treated with tapinarof cream 1% once daily (QD) for up to 52 weeks.