CEP44 and CCDC15 label the spermatozoa proximal and atypical distal centrioles.

The centrosome is a conserved characteristic of eukaryotic and human cells but is highly specialized in reproductive cells. The spermatozoan centrosome includes a slightly modified proximal centriole, an atypical distal centriole, and specialized pericentriolar material, including striated columns and capitellum. We investigated the localization of canonical centriolar proteins CEP44 and CCDC15 in human spermatozoa.

Does Fluoroscopic-Aided Enabling Technology Improve Acetabular Component Position and Reduce Radiation Exposure in Direct Anterior Total Hip Arthroplasty?

Accurate acetabular component positioning is crucial for the success of total hip arthroplasty (THA). Malplacement of the acetabular component increases the risk of post-surgery complications, most notably dislocation.1 Furthermore, malposition can also result in wear of the polyethylene liner, limited range of motion, and osteolysis.

Organ-sparing partial glansectomy: an alternative surgical management for invasive penile carcinoma-case report.

Background: Penile cancer is a rare malignancy treated via various surgical techniques guided by disease stage and grade with current guidelines suggesting partial or total penectomy for those with pT2 or greater. We report a case of a patient with pT2 squamous cell carcinoma (SCC) of the penis who underwent circumcision with left partial-glansectomy and resection of preputial mass with good oncological control while providing good urinary and sexual function.

Case Description: An 82-year-old male presented to the clinic due to a mass that doubled in size in an 8-month timeframe.

De Novo Atherosclerotic Renal Artery Stenosis Covered Stent Treatment for Resistant Hypertension (ARTISAN) Results.

Background: Atherosclerotic renal artery stenosis (ARAS) may provoke hypertension and/or impaired kidney function. Some patients develop uncontrolled hypertension and deteriorating kidney function despite optimal medical therapy. In these patients, endovascular treatment is an important therapeutic option.

The Association Between Primary Sclerosing Cholangitis and Microscopic Colitis: A Systematic Review.

The association between primary sclerosing cholangitis (PSC) and microscopic colitis (MC) has been explored in limited studies, suggesting potential shared pathophysiological mechanisms. This systematic review aimed to investigate this relationship by analyzing studies identified through comprehensive searches in PubMed, Embase, and the Cochrane Library. Two studies met the inclusion criteria: a case series of 12 patients and a case report, collectively analyzing 13 cases.

Incidental finding of levocardia with situs inversus: case report.

"Situs inversus with levocardia" refers to the mirror-image lateral orientation of the abdominal organs with a normally oriented, left-sided heart. This anatomical anomaly arises from abnormalities in the biochemical signaling systems mediating embryological development. We present a case of situs inversus with levocardia incidentally discovered in a healthy 24-year-old male during workup following a motor vehicle collision.

Racial and Ethnic Disparities in the Outcomes and Treatment of Patients Admitted with Heart Failure: A Nationwide Analysis.

: Heart failure is the leading cause of hospital admission and mortality. Racial disparities have been demonstrated in various cardiovascular disorders; however, the data for in-hospital outcomes, complications, and procedural rates are limited. : Utilizing the National Inpatient Sample (NIS) database, this retrospective cohort study included adult patients admitted with a principal diagnosis of heart failure.

Esophageal Adenocarcinoma Presenting With Hypercalcemia.

Hypercalcemia is an identified complication of several malignancies and can cause significant adverse events. It is usually associated with cancers of the breast, lung (especially squamous cell), renal cell carcinoma, and multiple myeloma. Here, we present a rare case of esophageal adenocarcinoma presenting with hypercalcemia.

Influence of cadence manipulation on running biomechanics in high school cross-country runners.

Increasing cadence is an intervention to reduce injury risk for adolescent long-distance runners. It is unknown how adolescents respond biomechanically when running with a higher than preferred cadence. We examined the influence of increasing cadence on peak joint angles, moments and powers, and ground reaction forces in long-distance runners.

The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses.

Background/objectives: The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated carbohydrate antigens (TACAs). However, PS A1 cannot elicit cytotoxic T lymphocytes through MHCI, which may or may not hamper its potential clinical use in cancer, infectious and viral vaccine development. This paper addresses PS A1 MHCI independence through the introduction of an MHCI epitope, the poliovirus (PV) peptide, to establish an MHCI- and MHCII-dependent vaccine.

A Review of the Consequences of Gut Microbiota in Neurodegenerative Disorders and Aging.

Age-associated alterations in the brain lead to cognitive deterioration and neurodegenerative disorders (NDDs). This review with a particular focus on Alzheimer's disease (AD), emphasizes the burgeoning significance of the gut microbiota (GMB) in neuroinflammation and its impact on the gut-brain axis (GBA), a communication conduit between the gut and the central nervous system (CNS). Changes in the gut microbiome, including diminished microbial diversity and the prevalence of pro-inflammatory bacteria, are associated with AD pathogenesis.

Carotid Cavernous Fistula and Its Association With Spine Surgery: A Case Report.

A carotid cavernous fistula (CCF) is a disruption in the carotid arteries within the cavernous sinus. The pooling of blood in the sinus causes a myriad of neurological deficits. When correctly diagnosed, this condition can be easily managed through surgical intervention.

Clinical Impact of Admission Day on Outcomes in Acutely Decompensated Aortic Stenosis: A Nationwide Analysis.

Aortic stenosis (AS) is a critical valvular heart disease associated with significant morbidity and mortality if not managed promptly. Previous studies have highlighted the "weekend effect", where the day of admission impacts outcomes in various cardiac conditions. This study evaluates the impact of weekend versus weekday admissions on outcomes in patients admitted with acutely decompensated aortic stenosis.

Injectable promethazine in clinics and hospitals: What's the alternative?

The Institute for Safe Medication Practices and the American Society of Health-System Pharmacists have advocated for removing all injectable promethazine from inpatient and outpatient settings; however, this drug is still being used despite the risk for tissue necrosis, gangrene, and possible amputation when it inadvertently is given by the subcutaneous or intra-arterial route. This article describes alternative injectable medications that can be selected based on patient comorbidities, indications, and clinician experience.

A randomised controlled study on efficacy of midazolam and cartoon for decreasing preoperative anxiety in preschool children undergoing strabismus surgery.

Background: This study aimed to evaluate the effect and influence of midazolam and cartoon on postoperative behaviour in reducing preoperative anxiety in preschool children.

Methods: Three hundred children undergoing monocular strabismus correction were divided into three groups: midazolam (M), cartoon (C), and CM. Preoperative anxiety scores, cooperation scores during anaesthesia induction, awakening time, emergence agitation, and postoperative adverse behaviours were recorded.

Long-Term Decision Regret and Associated Factors After Urinary Reconstruction in Underserved Patients With Spinal Cord Injury.

Purpose: Patients with refractory neurogenic bladder dysfunction may require urinary reconstruction due to severe incontinence, difficulty with catheterization, and to prevent upper urinary tract compromise. We evaluated long-term decisional regret and associated factors after urinary reconstruction in patients with spinal cord injury.

Materials And Methods: We interviewed patients with spinal cord injuries who underwent bladder reconstruction surgery at least 10 years ago, administering validated surveys on bowel quality of life (QoL) and dysfunction, UTIs, and decisional regret.

Comparative analysis of ischemic and hemorrhagic stroke hospitalization rates in end-stage kidney disease and kidney transplant patients with and without atrial fibrillation.

Introduction: Atrial fibrillation (AF) in end-stage kidney disease (ESKD) and kidney transplant (KTx) recipients presents challenges in stroke risk management. This study aimed to compare hospitalization rates for ischemic and hemorrhagic cerebrovascular events in ESKD and KTx patients with and without AF.

Methods: Using the National Inpatient Sample (2005-2019), retrospective analysis was conducted on hospitalizations for ESKD and KTx patients with and without AF.

Evaluation of the Efficacy of Piperacillin/Tazobactam in Extended-Spectrum Beta-Lactamase-Producing Urinary Tract Infections: A Systematic Review of the Literature.

Objective: To evaluate the efficacy of piperacillin/tazobactam (PTZ) for the treatment of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL-PE) urinary tract infections (UTIs).

Data Sources: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards on PubMed, MEDLINE, Embase, Web of Science Core Collection, and Cochrane Central through July 2024.

Study Selection And Data Extraction: Studies providing efficacy data associated with PTZ in patients ≥18 years old experiencing an ESBL-PE UTI that documented clinical and microbiological cure data were included.

Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity.

Introduction: A growing body of literature associates branched-chain amino acid (BCAA) catabolism to increased fatty acid oxidation and better metabolic health. Hence, BCAA-rich diets may improve body composition and muscle protein synthesis. However, the role of individual characteristics such as a low aerobic fitness, a well-established risk factor for cardio-metabolic diseases, has not been studied.

Psychometric Evaluation of the Heterosexist Harassment, Rejection, and Discrimination Scale: Identification of a Unidimensional 11-Item Scale.

Despite the Heterosexist Harassment, Rejection, and Discrimination Scale (HHRDS) being a routinely used measure of discrimination, there is no current consensus regarding its fundamental psychometric properties. This study sought to: (a) test the dimensionality of the scale using a classical test theory approach, and (b), if lacking a clear multidimensional structure, use an item response theory approach to develop a concise unidimensional measure and examine differential item and test functioning across various identity factors. In a sample of sexual minority adults ( = 1,243), evaluation of the HHRDS supported a reduced 11-item unidimensional measure.

Evaluation of the Physical Compatibility of Intravenous Methocarbamol in Lactated Ringer's, 0.45% Normal Saline, and Plasma-Lyte A.

The need to determine physical compatibility of intravenous admixtures is directly related to patient safety and patient outcomes. While the provision of multi-modal analgesic strategies has increased over the past decade, a paucity of data exists regarding physical compatibility of select medications. To evaluate the physical compatibility of methocarbamol in Lactated Ringer's (LR), 0.

Grade I and Grade II Penile Strangulation From a Plastic Bottleneck.

In this case report, we present two clinical cases of penile strangulation caused by a bottleneck at the base of the penis. In the first case, corporal aspiration was used to decrease the blood that is trapped in the corpora due to the constriction. A rotating saw was used to incise the bottleneck in a full-thickness manner.