1 results match your criteria: "The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan hirokioguri@g.ecc.u-tokyo.ac.jp.[Affiliation]"
Direct photochemical intramolecular [4 + 2] cycloadditions of dehydrosecodine-type substrates for the synthesis of the -type scaffold and divergent [2 + 2] cycloadditions employing micro-flow system.
Chem Sci
September 2024
Department of Chemistry, Graduate School of Science, The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan
Article Synopsis
- Photocyclisation reactions provide a useful method for creating complex polycyclic structures, especially in natural product synthesis, with the [4 + 2] reaction being less explored than its [2 + 2] counterpart.
- This study introduced the rapid assembly of a -type scaffold using an intramolecular Diels-Alder reaction on a dehydrosecodine-type intermediate, achieving up to 77% yield under mild conditions via a micro-flow system.
- The research highlights the direct UV-LED activation of the DHP moiety, allowing for efficient [4 + 2] and [2 + 2] cyclisations without needing external photocatalysts, thus showcasing a novel approach to exploiting the reactivity of polyuns