Nitroxide-Functionalized Graphene Oxide from Graphite Oxide.

A facile method for preparing functionalized graphene oxide single layers with nitroxide groups is reported herein. Highly oxidized graphite oxide (GO=90.6%) was obtained, slightly modifying an improved Hummer's method.

Two homologous EF-G proteins from Pseudomonas aeruginosa exhibit distinct functions.

Genes encoding two proteins corresponding to elongation factor G (EF-G) were cloned from Pseudomonas aeruginosa. The proteins encoded by these genes are both members of the EFG I subfamily. The gene encoding one of the forms of EF-G is located in the str operon and the resulting protein is referred to as EF-G1A while the gene encoding the other form of EF-G is located in another part of the genome and the resulting protein is referred to as EF-G1B.

Prepubertal exposure to arsenic(III) suppresses circulating insulin-like growth factor-1 (IGF-1) delaying sexual maturation in female rats.

Arsenic (As) is a prevalent environmental toxin readily accessible for human consumption and has been identified as an endocrine disruptor. However, it is not known what impact As has on female sexual maturation. Therefore, in the present study, we investigated the effects of prepubertal exposure on mammary gland development and pubertal onset in female rats.

Pharmaceuticals, political money, and public policy: a theoretical and empirical agenda.

Why, when confronted with policy alternatives that could improve patient care, public health, and the economy, does Congress neglect those goals and tailor legislation to suit the interests of pharmaceutical corporations? In brief, for generations, the pharmaceutical industry has convinced legislators to define policy problems in ways that protect its profit margin. It reinforces this framework by selectively providing information and by targeting campaign contributions to influential legislators and allies. In this way, the industry displaces the public's voice in developing pharmaceutical policy.

Cloning and characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa.

We have cloned genes encoding elongation factors EF-Tu and EF-Ts from Pseudomonas aeruginosa and expressed and purified the proteins to greater than 95% homogeneity. Sequence analysis indicated that P. aeruginosa EF-Tu and EF-Ts are 84% and 55% identical to E.

Development of a quality ranking model for home health care providers.

This research aims to increase transparency and simplify consumer decision-making regarding the selection of a home health care provider. Currently, quality information on home health care providers is fragmented and difficult to interpret. In this study, a quality-ranking model is developed by selecting multidimensional quality indicators across multiple sources and respective weights using expert judgment.

A green approach toward quinoxalines and bis-quinoxalines and their biological evaluation against A431, human skin cancer cell lines.

Background: The objective of this study was to develop a practical green procedure to synthesize quinoxalines and bis-quinoxalines and evaluate their inhibitory effects on the viability of A431 human epidermoid carcinoma cells.

Method: A series of quinoxaline and bis-quinoxaline derivatives have been designed and synthesized following a microwave-assisted and bismuth nitrate-catalyzed eco-friendly route. A detailed comparison has been made between microwave-induced protocol with the reactions occurred at room temperature.

A novel Bacillus thuringiensis Cry-like protein from a rare filamentous strain promotes crystal localization within the exosporium.

Mutation of a novel cry-like gene (cry256) from Bacillus thuringiensis resulted in a protein crystal, normally located within the spore's exosporium, being found predominately outside the exosporium. The cry256 gene codes for a 3-domain Cry-like protein that does not correspond to any of the known Cry protein holotypes.

Health care access and utilization among Hispanic manufacturing workers along the Texas-Mexico border.

Disparities in health care access, including utilization of preventive health services, are well-documented among ethnic minority populations. This study examines factors associated with health care access and utilization among Hispanic manufacturing employees along the Texas-Mexico border. A cross-sectional survey was administered in 2010 to 228 mostly male (71%) workers.

Contact with gays and lesbians and same-sex marriage support: The moderating role of social context.

Empirical research on the contact hypothesis has paid inadequate attention to the broader social and normative context in which contact occurs. Using data from the nationally representative Portraits of American Life Study, I test whether individuals' core networks moderate the effect of personal contact with gays and lesbians on same-sex marriage attitudes. OLS regression results demonstrate that, though contact is strongly associated with greater support for same-sex marriage, the effect is attenuated for individuals with a higher proportion of religious conservatives in their core network.

Seniors, health information, and the Internet: motivation, ability, and Internet knowledge.

Providing health information to older adults is crucial to empowering them to better control their health, and the information is readily available on the Internet. Yet, little is known about the factors that are important in affecting seniors' Internet search for health information behavior. This work addresses this research deficit by examining the role of health information orientation (HIO), eHealth literacy, and Internet knowledge (IK) in affecting the likelihood of using the Internet as a source for health information.

Study of the thermodynamics of chromium(III) and chromium(VI) binding to iron(II/III)oxide or magnetite or ferrite and magnanese(II) iron (III) oxide or jacobsite or manganese ferrite nanoparticles.

Removal of chromium(III) or (VI) from aqueous solution was achieved using Fe3O4, and MnFe2O4 nanomaterials. The nanomaterials were synthesized using a precipitation method and characterized using XRD. The size of the nanomaterials was determined to be 22.

A Practical Green Synthesis and Biological Evaluation of Benzimidazoles Against Two Neglected Tropical Diseases: Chagas and Leishmaniasis.

Antimicrobial resistance is an ever-increasing problem throughout the world and has already reached severe proportions. Two very common neglected tropical diseases are Chagas' disease and leishmaniasis. Chagas' disease is a severe health problem, mainly in Latin America, causing approximately 50000 deaths a year and millions of people are infected.

An expeditious iodine-catalyzed synthesis of 3-pyrrole-substituted 2-azetidinones.

2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. Following this method, a series of 3-pyrrole- substituted 2-azetidinones have been synthesized with a variety of substituents at N-1 and at C-4.

Negative-order Korteweg-de Vries equations.

In this paper, based on the regular Korteweg-de Vries (KdV) system, we study negative-order KdV (NKdV) equations, particularly their Hamiltonian structures, Lax pairs, conservation laws, and explicit multisoliton and multikink wave solutions thorough bilinear Bäcklund transformations. The NKdV equations studied in our paper are differential and actually derived from the first member in the negative-order KdV hierarchy. The NKdV equations are not only gauge equivalent to the Camassa-Holm equation through reciprocal transformations but also closely related to the Ermakov-Pinney systems and the Kupershmidt deformation.

Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity.

Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed.

Do Marmorkrebs, Procambarus fallax f. virginalis, threaten freshwater Japanese ecosystems?

Background: One marbled crayfish, Marmorkrebs, Procambarus fallax f. virginalis (Hagen, 1870), was discovered in a natural ecosystem in Japan in 2006. Because Marmorkrebs are parthenogenetic, they could establish a population from only a single individual, and thus pose a risk for becoming established in Japan, as they have in other countries.

Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles.

Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.

Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrofuran has been accomplished with excellent yield.

Identifying Occupational Performance Barriers of Stroke Survivors: Utilization of a Home Assessment.

Background: Stroke survivors often have impairments that make it difficult for them to function safely in their home environment.

Purpose: The purpose of this study is to identify occupational performance barriers in the home and describe the subsequent recommendations offered to stroke survivors and their caregivers.

Methods: An occupational therapist administered a home safety tool to assess stroke survivors' home environments, determine home safety problems, and provide recommendations.

SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis.

Apoptosis is intimately connected to cell cycle regulation via the Retinoblastoma (Rb)-E2F pathway and thereby serves an essential role in tumor suppression by eliminating aberrant hyperproliferative cells. Upon loss of Rb activity, an apoptotic response can be elicited through both p53-dependent and p53-independent mechanisms. While much of this apoptotic response has been attributed to the p19ARF/p53 pathway, increasing evidence has supported the role of protein tyrosine phosphatases (PTPs) in contributing to the initiation of the Rb-E2F-associated apoptotic response.

Bismuth nitrate-induced microwave-assisted expeditious synthesis of vanillin from curcumin.

Background: Curcumin and vanillin are the two useful compounds in food and medicine. Bismuth nitrate pentahydrate is an economical and ecofriendly reagent.

Method: Bismuth nitrate pentahydrate impregnated montmorillonite KSF clay and curcumin were subjected to microwave irradiation.

Alliance for a Healthy Border: factors related to weight reduction and glycemic success.

We examined the factors related to success in achieving weight reduction and glycemic control in Alliance for a Healthy Border (AHB), a chronic disease prevention program implemented from 2006 to 2009 through 12 federally qualified community health centers serving primarily Hispanics in communities located along the US-Mexico border region. We analyzed data from Phase I of AHB using logistic regression to examine the determinants of success in achieving weight reduction and glycemic control among the participants in AHB programs. Factors affecting weight reduction success were sex, age, employment status, income, insurance, diabetes, baseline body mass index (BMI), smoking status, family history of diabetes, session type, program duration, and physical activity changes.

Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction.

Background: The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives.

Results: Polystyrenesulfonate-catalyzed simple synthesis of substituted pyrroles following Paal-Knorr reaction has been accomplished with an excellent yield in aqueous solution. This method also produces pyrroles with multicyclic polyaromatic amines.

A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines.

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules.

Bismuth nitrate pentahydrate-induced novel nitration of eugenol.

Background: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds.