High-throughput determination of enantiopurity in atroposelective synthesis of aryl triazoles.

Atropisomeric scaffolds are a common design element found in pharmaceuticals, many deriving from an N-C axis of chirality. The handedness associated with atropisomeric drugs is oftentimes crucial for their efficacy and/or safety. With the increased use of high-throughput screening (HTS) for drug discovery, the need for rapid enantiomeric excess () analysis is needed to keep up with the fast workflow.