1 results match your criteria: "The University of Texas at Austin Austin TX 78712 USA cbaiz@cm.utexas.edu.[Affiliation]"
How cryoprotectants work: hydrogen-bonding in low-temperature vitrified solutions.
Chem Sci
August 2022
Department of Chemistry, The University of Texas at Austin Austin TX 78712 USA
Article Synopsis
- DMSO (Dimethyl sulfoxide) is effective as a cryoprotectant, improving cell and tissue viability in low temperatures by disrupting hydrogen-bond networks in water and inhibiting ice formation.
- Through techniques like FTIR and molecular dynamics simulations, the study investigates how DMSO interacts with water from 30 °C to -80 °C, revealing significant disruption in hydrogen bonding compared to normal water.
- The findings indicate that the disrupted hydrogen bond networks are mainly confined to the area directly surrounding DMSO, which helps explain the necessity for high DMSO concentrations to avoid ice crystal growth during cryopreservation.