1 results match your criteria: "The University of Texas at Arlington Arlington Texas 76019-0065 USA colin.cameron@uta.edu sherri.mcfarland@uta.edu.[Affiliation]"
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Chem Sci
November 2020
Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington Texas 76019-0065 USA
Article Synopsis
- Over the last 20 years, photodynamic therapy (PDT) has shown potential not just as a local cancer treatment, but also for triggering a systemic immune response that helps prevent tumor recurrence, particularly in aggressive cancers like melanoma.
- Researchers have developed nine new near-infrared (NIR) photosensitizers (PSs) based on a specific chemical structure that demonstrate strong effectiveness against melanoma cells, achieving low concentrations for significant phototoxic effects with NIR light.
- When tested in mice, PDT treatment with one of the PSs activated a pro-inflammatory response and induced immunogenic cell death, resulting in substantial protection from tumor growth and improved survival rates after vaccination and subsequent tumor challenges.