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Chemical construction of immunotoxins.
Methods Mol Med
October 2012
Department of Microbiology and Cancer Immunobiology Center, The University of Texas South Western Medical Center at Dallas, TX.
Immunotoxins (ITs) are chimeric proteins consisting of an antibody linked to a toxin. The antibody confers specificity (ability to recognize and react with the target), whereas the toxin confers cytotoxicity (ability to kill the target) (1-3). ITs have been used in both mice and humans to eliminate tumor cells, autoimmune cells, and virus-infected cells (4-6.
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