6 results match your criteria: "The University of Texas School of Public Health Houston[Affiliation]"
Opportunities and Challenges in Developing a Controlled Human Infection Model for Testing Antiparasitic Agents.
ACS Infect Dis
May 2021
Novartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.
Article Synopsis
- Cryptosporidiosis causes severe diarrhea and high mortality in children under two, especially in low and middle-income countries, and is linked to malnutrition and growth stunting.
- Current treatments are inadequate, but new therapeutic agents show promise from recent screening methods and repurposing studies.
- Using a Controlled Human Infection Model (CHIM) with healthy adults could help establish safety and efficacy for pediatric treatments, potentially speeding up the process to bring effective therapies to vulnerable children.
Prevalence and incidence of anal human papillomavirus infection in Mexican men: Need for universal prevention policies.
Salud Publica Mex
August 2019
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.
Objective: Describe the natural history of anal HPV among men.
Materials And Methods: Prospective study among men 18-70 years (n=665), from Cuernavaca, Mexico who completed questionnaires and provided specimens (HPV genotyped) at enrollment and 1+ follow-up visit. HPV prevalence and incidence were estimated.
Teaching Caregivers of Persons with Dementia to Address Pain.
Am J Geriatr Psychiatry
February 2017
Houston VA HSR&D Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, TX; Baylor College of Medicine, Houston, TX; VA South Central Mental Illness Research, Education and Clinical Center, United States.
Objectives: To compare the efficacy of Preventing Aggression in Veterans with Dementia (PAVeD) with that of usual care in decreasing incidence of aggression (primary outcome) and pain and improving depression, pleasant events, caregiver burden, and patient-caregiver relationship quality (secondary outcomes).
Design: Randomized controlled trial with assessments at baseline and 3, 6, 9, and 12 months SETTING: Houston, TX.
Participants: A total of 203 community-dwelling veterans with pain and dementia and their caregivers.
Background: Bevacizumab (BV) is broadly used to treat a number of cancers; however, BV resistance mechanisms and strategies to overcome this resistance are yet to be determined.
Methods: We established xenograft mice models harboring Kirsten rat sarcoma oncogene homolog (KRAS) mutations based on the A549 cell line, and tested the responses of xenograft tumors to a series of drugs in ex vivo and in vivo experiments. Changes in transcriptive level were analyzed by ribonucleic acid (RNA) sequencing and the expressions of connexins were determined by immunohistochemistry staining.
The Quality of Pain Treatment in Community-Dwelling Persons with Dementia.
Dement Geriatr Cogn Dis Extra
March 2016
Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Houston, Tex., USA; Baylor College of Medicine, Houston, Tex., USA; VA South Central Mental Illness Research, Education and Clinical Center, Houston, Tex., USA.
Article Synopsis
- A study analyzed pain care quality for elderly patients with dementia, revealing that despite high documentation of pain assessments (98%), many patients still suffered without proper treatment.
- Although 70% of participants reported significant pain, 64% had no pain documented in their medical records, indicating a disconnect between patient experiences and clinical observations.
- Only 59% received follow-up assessments after treatment was offered, and non-drug pain management strategies were largely overlooked, highlighting the need for improved pain care in this demographic.
Beta-2-glycoprotein I (beta2GP1) has been implicated as the primary antigenic target in antiphospholipid syndrome. To study the role beta2GP1 antibodies play in thrombosis associated with this syndrome, the clearance and binding of phosphatidylserine (PS)-containing target membranes were monitored in beta2GP1-immune mice. Clearance in immune mice (T(1/2)4.
View Article and Find Full Text PDF