3 results match your criteria: "The University of Texas Health Science Center at Houston Institute of Molecular Medicine[Affiliation]"
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Nat Commun
September 2018
The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.
Article Synopsis
- The study investigates the genetic factors influencing the volume of lateral ventricles (LV) in the brain, which increases with age and is linked to various neurological disorders.
- Researchers analyzed genome-wide data from over 23,000 healthy individuals and identified 7 specific genetic loci related to LV volume, associated with critical brain pathways.
- A notable genetic connection was found between the lateral ventricles and the thalamus, indicating potential shared biological mechanisms influencing brain structure.
[Hematopoietic stem cell emergence and stem cell-independent hematopoiesis in the mouse embryo].
Rinsho Ketsueki
July 2019
University of Texas Health Science Center at Houston Institute of Molecular Medicine, Center for Stem Cell and Regenerative Medicine.
All blood cells are produced by hematopoietic stem cells (HSCs) in the adult bone marrow. However, prior to the emergence of the first HSCs at embryonic day (E) 11, mouse embryos present several hematopoiesis waves, such as primitive hematopoietic cells, definitive erythro-myeloid progenitors, lymphoid potent cells, and multi-potent progenitors. Non-HSC-derived hematopoiesis is called HSC-independent hematopoiesis and has been considered a transient wave that is diminished after birth.
View Article and Find Full Text PDFContribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.
Hum Mol Genet
June 2015
Department of Clinical Epidemiology and Biostatistics, Divisions of Genetics and Endocrinology, Children's Hospital, Boston, MA 02115, USA, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,
Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) ≥ 40 kg/m(2)], but their contribution to common obesity (BMI ≥ 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclear.
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