1 results match your criteria: "The University of Sydney NSW 2006 Australia david.hibbs@sydney.edu.au.[Affiliation]"
An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization.
RSC Adv
May 2022
Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney NSW 2006 Australia
Article Synopsis
- Theophylline (THEO) is a bronchodilator available in tablet and liquid forms but suffers from poor stability due to its hygroscopic nature, impacting its shelf-life as a medication.
- * Researchers aimed to improve THEO's stability by creating a cocrystal with malonic acid (MA), but tests showed no significant improvement in the cocrystal's hygroscopic properties.
- * High-resolution X-ray crystallography and Density Functional Theory analysis revealed that while the cocrystal has stable interactions, it does not significantly alter THEO's properties, indicating that returning to the original components (THEO and MA) is equally possible.