Gas gangrene due to Clostridium haemolyticum in a cat with aortic thromboembolism treated using clopidogrel and rivaroxaban.

A 12-year-old Bengal cat with unclassified cardiomyopathy presented for signs consistent with aortic thromboembolism (ATE). It was treated with clopidogrel and rivaroxaban as antithrombotic therapy, combined with narcotic analgesia and frusemide. After initially making a clinical improvement, the cat's condition suddenly deteriorated, with a presumptive diagnosis of clostridial myonecrosis.

Association of antenatal and early childhood air pollution and greenspace exposures with respiratory pathogen upper airway acquisitions and respiratory health outcomes.

The association of air pollution and greenspace with respiratory pathogen acquisition and respiratory health was investigated in a community-based birth-cohort of 158 Australian children. Weekly nasal swabs and daily symptom-diaries were collected for 2-years, with annual reviews from ages 3-7-years. Annual exposure to fine-particulate-matter (PM), nitrogen-dioxide (NO), and normalised-difference-vegetation-index (NDVI) was estimated for pregnancy and the first 2-years-of-life.

Effect of post-COVID-19 condition on sleep: A case report.

Post-COVID-19 condition affects patients on various aspects. This 41-year-old female presented to the outpatient clinic complaining of severe insomnia characterized by inconsistent 2 h of sleep per day despite taking sleep aid pills after being infected with COVID-19 and persisting for 6 months after recovery.

Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors in the world. Currently, there are no approved targeted therapies for PDAC. Mutations in () are known to be a major driver of PDAC progression, but it was considered an undruggable target until recently.

A Dual Protection System for Heterostructured 3D CNT/CoSe/C as High Areal Capacity Anode for Sodium Storage.

3D electrode design is normally opted for multiple advantages, however, instability/detachment of active material causes the pulverization and degradation of the structure, and ultimately poor cyclic stability. Here, a dually protected, highly compressible, and freestanding anode is presented for sodium-ion batteries, where 3D carbon nanotube (CNT) sponge is decorated with homogeneously dispersed CoSe nanoparticles (NPs) which are protected under carbon overcoat (CNT/CoSe/C). The 3D CNT sponge delivers enough space for high mass loading while providing high mechanical strength and faster conduction pathway among the NPs.

Rationally designed La and Se co-doped bismuth ferrites with controlled bandgap for visible light photocatalysis.

Development of efficient visible light photocatalysts for water purification and hydrogen production by water splitting has been quite challenging. The activities of visible light photocatalysts are generally controlled by the extent of absorption of incident light, band gap, exposure of catalyst surface to incident light and adsorbing species. Here, we have synthesized nanostructured, La and Se co-doped bismuth ferrite (BLFSO) nanosheets using double solvent sol-gel and co-precipitation methods.

Spectroscopic Approaches to Tracking Metal-based Drugs in Cells and Tissue.

Metal-based drugs with novel targets and modes of action are increasingly being developed as alternatives to classical platinum(ii) chemotherapeutics. Imaging methods in tumour cells and tissues offer valuable insights into the behaviour of these novel complexes; however, mapping the distribution of metal ions and complexes within cellular environments remains challenging. The advantages and limitations of three modes of imaging: synchrotron radiation-induced X-ray fluorescence, mass spectrometry, and fluorescence microscopy are discussed in this review, with particular emphasis on their use in imaging ruthenium-based drugs.

Comparative analysis of Staphylococcus epidermidis strains utilizing quantitative and cell surface shaving proteomics.

Unlabelled: Staphylococcus epidermidis is an opportunistic pathogen that is an emerging risk factor in hospitals worldwide and is often difficult to eradicate as virulent strains produce a protective biofilm matrix. We utilized cell shaving proteomics to profile surface-exposed proteins from two fully genome sequenced S. epidermidis strains: the avirulent, non-biofilm forming ATCC12228 and the virulent, strongly adherent biofilm forming ATCC35984 (RP62A).

Making leaves.

Leaves are determinate organs that develop from the flanks of the shoot apical meristem through founder cell recruitment, establishment of proximodistal, dorsoventral and mediolateral axes, and subsequent growth, expansion and differentiation along these axes. Maintenance of the shoot apical meristem and production of leaves requires balanced partitioning of cells between pluripotent and differentiation fates. Hormones have a significant role in this balance but it is becoming apparent that additional intrinsic and extrinsic inputs influence hormone signalling to control meristem function and leaf initiation.

Plant microtubule cytoskeleton complexity: microtubule arrays as fractals.

Biological systems are by nature complex and this complexity has been shown to be important in maintaining homeostasis. The plant microtubule cytoskeleton is a highly complex system, with contributing factors through interactions with microtubule-associated proteins (MAPs), expression of multiple tubulin isoforms, and post-translational modification of tubulin and MAPs. Some of this complexity is specific to microtubules, such as a redundancy in factors that regulate microtubule depolymerization.

Involvement of ribosomal protein RPL27a in meristem activity and organ development.

The plant shoot apical meristem is established early during embryogenesis and subsequently gives rise to a shoot through reiterative generation of lateral organs and axillary meristems. In our recent manuscript we reported identification and characterization of a semi-dominant mutation in ribosomal protein RPL27a, which disrupts plant growth and shoot development.1 rpl27ac-1d effects on the shoot are evident from an early stage of embryo development.

Simultaneous multi-channel OSNR monitoring with a wavelength selective switch.

We show the first simultaneous OSNR monitoring of two 40 Gb/s OOK and DPSK channels, using only a wavelength selective switch and two slow photodetectors. Our approach is modulation format and bit-rate independent and can easily be included in existing reconfigurable networks.

Arabidopsis thaliana, a plant model organism for the neuronal microtubule cytoskeleton?

The microtubule cytoskeleton is an important component of both neuronal cells and plant cells. While there are large differences in the function of microtubules between the two groups of organisms, for example plants coordinate the ordered deposition of cellulose through the microtubule cytoskeleton, there are also some notable similarities. It is suggested that Arabidopsis thaliana, with its superior availability of knockout lines, may be a suitable model organism for some aspects of the neuronal microtubule cytoskeleton.

The microtubule cytoskeleton acts as a key downstream effector of neurotransmitter signaling.

Microtubules are well known to play a key role in the trafficking of neurotransmitters to the synapse. However, less attention has been paid to their role as downstream effectors of neurotransmitter signaling in the target neuron. Here, we show that neurotransmitter-based signaling to the microtubule cytoskeleton regulates downstream microtubule function through several mechanisms.