Nonthermal Plasma Boosted Dichloroacetate Induces Metabolic Shifts to Combat Glioblastoma CSCs via Oxidative Stress.

Glioblastoma (GBM) remains a formidable clinical challenge, with cancer stem cells (CSCs) contributing to treatment resistance and tumor recurrence. Conventional treatments often fail to eradicate these CSCs characterized by enhanced resistance to standard therapies through metabolic plasticity making them key targets for novel treatment approaches. Addressing this challenge, this study introduces a novel combination therapy of dichloroacetate (DCA), a metabolic modulator and nonthermal plasma to induce oxidative stress in glioblastomas.

Effect of Exposed Facets and Oxidation State of CeO Nanoparticles on CO Adsorption and Desorption.

CeO nanoparticles exhibit potential as solid adsorbents for carbon dioxide (CO) capture and storage (CCS), offering precise control over various facets and enhancing their efficiency. This study investigated the adsorption and desorption behaviors of two types of CeO nanoparticles: cubic CeO with primarily {001} facets and polyhedral CeO with mainly {111} facets. The results showed that despite polyhedral CeO's lower quantity, it demonstrated successful adsorption-desorption cycles in both oxidized and reduced states.

The development and effects of a social constructivist approach in an interprofessional discomfort care online education program.

Background: The importance of interprofessional education (IPE) programs is increasing due to the complexity and multidimensional aspects of discomfort in long-term care facilities (LTCFs). The social constructivist approach, which is helpful in IPE, has received considerable attention in education. This study aimed to develop and identify the effects of an interprofessional discomfort management online education program using a social constructivist approach.

Characteristics and predictors of major occupational injuries in Korean farmers.

Farmers are exposed to various risks due to the nature of the agricultural environment, and occupational injuries occur consistently. Hence, this study aimed to investigate the characteristics and predictors of major non-fatal occupational injuries among farmers by analysing incidents of non-fatal occupational injuries resulting in at least 1 day off work using the Korean Agricultural Workers' Occupational Disease and Injury Survey data. Multivariate logistic regression was performed to identify the predictors of agricultural occupational injuries, and the results indicated that the risk for non-fatal injuries was higher among older individuals, individuals with pre-existing physical limitations and individuals who use agricultural machinery.

Engineering Delocalized Polarizations in Metal Oxide Electrodes with Conducting Polymers for Efficient and Durable Water-Splitting.

Oxygen evolution reaction is a pivotal anodic reaction for electrolysis, however, it remains the obstacle from its sluggish reaction kinetics originating from multiple electron transfer pathways at electrochemical interfaces. Especially, it remains a challenge to achieve stable operation at elevated current densities as electrodes suffer oxidative environment in corrosive conditions. Herein, we report that the conducting polymer polypyrrole electrodeposited PrSrCoO perovskite oxides for durable oxygen evolution electrodes.

Inactivation of Pseudovirus Expressing the D614G Spike Protein Mutation using Nitric Oxide-Plasma Activated Water.

Variants of concern (VOCs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) exhibit high infectivity due to mutations, particularly in the spike protein, that facilitate enhanced binding of virus to human angiotensin-converting enzyme 2 (hACE2). The D614G mutation, situated in S1-domain, promotes the open conformation of spike protein, augmenting its interaction with hACE2. Activated water neutralizes pathogens by damaging biological molecules; however, its effect on mutated SARS-CoV-2 or VOCs requires further exploration.

Antiaging in a Bottle: Bioactive Competency of Plasma-Generated Nitric Oxide Water for Modulation of Aging-Related Signature in Human Dermal Cells.

Nitric oxide (NO), a potential therapeutic antiaging molecule, modulates various physiological and cellular processes. However, alterations in endogenous NO levels brought on by aging impact multiple organ systems and heighten susceptibility to age-related skin diseases. This correlation underscores the importance of investigating NO-based antiaging interventions.

Ultrabroadband Photodetection with MoS and Gold Nanorod Using Gap-Mode Plasmon Effect.

Plasmon resonance using metal nanostructures enables the realization of high-performance optoelectronic devices via field enhancements in the vicinity of the metal nanostructure. This study proposes an ultrabroadband MoS photodetector based on the gap-mode plasmon of gold nanorods. The use of MoS as a gap spacer for the gap-mode plasmon effect and as a channel material for the photodetector is demonstrated.

Optimizing Surface Characteristics of Stainless Steel (SUS) for Enhanced Adhesion in Heterojunction Bilayer SUS/Polyamide 66 Composites.

The increasing environmental concerns and stringent regulations targeting emissions and energy efficiency necessitate innovative material solutions that not only comply with these standards but also enhance performance and sustainability. This study investigates the potential of heterojunction bilayer composites comprising stainless steel (SUS) and polyamide 66 (PA66), aiming to improve fuel efficiency and reduce harmful emissions by achieving lightweight materials. Joining a polymer to SUS is challenging due to the differing physical and chemical properties of each material.

Ideals and Reality of Public Health Nursing in Korea: Influence of U.S. Nurse Advisors, 1945~1961.

South Korea's national healthcare system after liberation often described as transformation from 'sanitation' to 'public health'. The U.S.

1.5 million materials narratives generated by chatbots.

The advent of artificial intelligence (AI) has enabled a comprehensive exploration of materials for various applications. However, AI models often prioritize frequently encountered material examples in the scientific literature, limiting the selection of suitable candidates based on inherent physical and chemical attributes. To address this imbalance, we generated a dataset consisting of 1,453,493 natural language-material narratives from OQMD, Materials Project, JARVIS, and AFLOW2 databases based on ab initio calculation results that are more evenly distributed across the periodic table.

Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations.

Numerous studies have established associations between vitamin D and diabetes. The vitamin D receptor is widely distributed throughout the human body, including in pancreatic beta cells (β-cells), hepatocytes, and immune cells. Therefore, vitamin D's effect on the risk, progression, or complications of diabetes may be mediated through various mechanisms.

Examining plasma-generated ozone and nitric oxide's role in synthetic textile dye water remediation and ecotoxicological analysis.

Synthetic dyes produced by the textile dyeing industry and released into wastewater contribute significantly to water pollution. This study explores the efficacy and versatility of a novel multi-electrode dielectric barrier discharge (MEDBD) plasma system that mainly generates ozone (O generator) and nitric oxide (NO generator) selectively to degrade various synthetic textile dyes, namely Methylene Blue (MB), Congo Red (CR), Methyl Orange (MO), Crystal Violet (CV), and Evans Blue (EB). Plasma achieved selective enrichment of O and NO by utilizing optimized plasma generation duty cycles of 15% and 100%, respectively.

Application of mesenchymal stem cells exosomes as nanovesicles delivery system in the treatment of breast cancer.

As people's living standards continue to improve and human life span expectancy increases, the incidence and mortality rates of breast cancer are continuously rising. Early detection of breast cancer and targeted therapy for different breast cancer subtypes can significantly reduce the mortality rate and alleviate the suffering of patients. Exosomes are extracellular vesicles secreted by various cells in the body.

Anoctamin 1, a multi-modal player in pain and itch.

Anoctamin 1 (ANO1/TMEM16A) encodes a Ca-activated Cl channel. Among ANO1's many physiological functions, it plays a significant role in mediating nociception and itch. ANO1 is activated by intracellular Ca and depolarization.

Enhanced dye degradation using plasma bubbles for the sustainable environmental remediation.

This study proposes a novel and eco-friendly approach for wastewater treatment using plasma jet technology under bubble condition. This method allows for the controlled production of highly reactive hydroxyl radicals (OH•) while minimizing unwanted interactions with nitrogen in the air. The presence of bubbles in liquid significantly boosts the diffusion of OH• within the wastewater, leading to a two-fold increase in degradation rate compared to normal condition.

Cold Atmospheric Pressure Plasma Solutions for Sustainable Food Packaging.

Increasing the number of resistant bacteria resistant to treatment is one of the leading causes of death worldwide. These bacteria are created in wounds and injuries and can be transferred through hospital equipment. Various attempts have been made to treat these bacteria in recent years, such as using different drugs and new sterilization methods.

Exploring Predictive Factors for Heart Failure Progression in Hypertensive Patients Based on Medical Diagnosis Data from the MIMIC-IV Database.

Heart failure is associated with a significant mortality rate, and an elevated prevalence of this condition has been noted among hypertensive patients. The identification of predictive factors for heart failure progression in hypertensive individuals is crucial for early intervention and improved patient outcomes. In this study, we aimed to identify these predictive factors by utilizing medical diagnosis records for hypertension patients from the MIMIC-IV database.

Electromagnetic Interference Shielding Properties of Highly Flexible Poly(styrene-co-butyl acrylate)/PEDOT:PSS Films Fabricated by Latex Technology.

As the use of stretchable electronic devices increases, the importance of flexible electromagnetic interference (EMI) shielding films is emerging. In this study, a highly flexible shielding film was fabricated using poly(styrene-co-butyl acrylate) (p(St-co-BA)) latex as a matrix and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as a conductive filler, and then the mechanical properties and EMI shielding performance of the film were examined. Styrene and butyl acrylate were copolymerized to lower the high glass transition temperature and increase the ductility of brittle polystyrene.