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Prevalence and molecular study of G6PD deficiency in Malaysian Orang Asli.

Intern Med J

April 2011

School of Bioscience and Biotechnology, Faculty of Science and Technology, PERMATApintar UKM, The University of Kebangsaan Malaysia, Selangor Human Genome Centre, The University of Sains Malaysia, Kelantan, Malaysia.

This study aims to define the prevalence and the molecular basis of G6PD deficiency in the Negrito tribe of the Malaysian Orang Asli. Four hundred and eighty seven consenting Negrito volunteers were screened for G6PD deficiency through the use of a fluorescent spot test. DNA from deficient individuals underwent PCR-RFLP analysis using thirteen recognized G6PD mutations.

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