1 results match your criteria: "The University of Queensland School of Biomedical Sciences[Affiliation]"
Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos.
Biol Reprod
April 2010
The University of Queensland School of Biomedical Sciences, Brisbane, Queensland 4072, Australia.
Article Synopsis
- Maternal hyperglycemia is linked to early pregnancy loss and congenital malformations, likely due to its effects on the hexosamine signaling pathway (HSP) and O-GlcNAcylation during early embryonic development.
- An in vitro study used mouse zygotes exposed to different glucose levels and glucosamine to assess the impact on blastocyst formation, cell proliferation, and apoptosis, revealing that increased HSP flux from hyperglycemia negatively affected these parameters.
- Inhibiting key enzymes involved in O-GlcNAcylation reversed the detrimental effects of hyperglycemia, indicating that dysregulation of this signaling pathway plays a critical role in the negative outcomes observed in diabetic pregnancies.