107 results match your criteria: "The University of Queensland Medical School[Affiliation]"

Background: Stroke requires timely intervention, with carotid endarterectomy (CEA) and carotid artery stenting (CAS) increasingly used in select acute carotid-related stroke patients. We aimed to build a model to predict neurologic functional independence (modified Rankin scale, mRS ≤ 2) in this high-risk group.

Study Design: We analyzed data from 302 stroke patients undergoing urgent CEA or CAS between 2015 and 2023 at a tertiary Comprehensive Stroke Center.

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Spinal cord sarcoidosis, an uncommon manifestation of neurosarcoidosis, presents diagnostic and therapeutic challenges because the condition is rare and has diverse clinical manifestations that can mimic other conditions such as multiple sclerosis and neuromyelitis optica spectrum disorder. A middle-aged African American female with a history of idiopathic intracranial hypertension and hydrocephalus with ventriculoperitoneal shunt presented with progressive, predominantly left-sided gait instability, weakness, and paresthesia. Cerebrospinal fluid showed lymphocytosis, red blood cells, elevated oligoclonal bands, and elevated kappa free light chains, concerning for multiple sclerosis.

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Patients and providers vary in how they describe common otolaryngology-related complaints. These differences can lead to miscommunication and frustration that may affect patient outcomes and satisfaction. The aim of this cross-sectional survey-based study was to explore the differences in migraine symptom selection by otolaryngology patients and clinicians.

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Happy Holidays and Happy New Year.

Ochsner J

January 2024

Director of Clinical School and Professor, The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA; Editor-in-Chief, Ochsner Journal.

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The Disappearance of Black Men From Medicine: A Consequence of Racism and the Flexner Report.

Ochsner J

January 2024

Department of Rheumatology, Ochsner Clinic Foundation, New Orleans, LA and The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA.

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The Xavier Ochsner College of Medicine - "The Time Is Always Right To Do What Is Right".

Ochsner J

January 2024

Global Health and Education, Ochsner Clinic Foundation, New Orleans, LA and The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA.

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Despite the substantial expenditures on health care in the United States, persistent underperformance in health system metrics necessitates innovative approaches to address complex patient needs. The MedVantage Clinic in New Orleans, Louisiana, offers a regionally tailored, value-based primary care model targeting patients with high social and medical needs. This study provides an evaluation of the efficacy of the MedVantage Clinic in improving the cost of care and service utilization for this population.

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Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.

Nat Commun

December 2024

Queensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder.

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So What?

Ochsner J

January 2024

Department of Anesthesiology and Perioperative Medicine, Ochsner Clinic Foundation, New Orleans, LA and The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA.

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Autumn Is Coming.

Ochsner J

January 2024

Director of Clinical School and Professor, The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA; Editor-in-Chief, Ochsner Journal.

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Article Synopsis
  • Obesity, defined as a body mass index ≥30 kg/m², is widespread in the U.S. and linked to various health risks; the study focuses on its effect on the need for instrumental vaginal delivery during childbirth.
  • This retrospective study analyzed data from women in active labor to evaluate the association of maternal obesity with the incidence of instrumental deliveries, using effect size measures for better accuracy compared to frequentist tests.
  • The findings indicated that while maternal obesity was more common in women with certain health issues, it did not have a significant clinical impact on the need for instrumental delivery.
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Achondroplasia can result in many skeletal manifestations, and degenerative osteoarthritis can develop in patients with achondroplasia. Morphologic changes to both the humerus and glenoid-short humeri with patulous metaphyses and a medialized glenoid-can cause challenges that must be overcome to achieve a successful surgical result in a patient with shoulder dysfunction. Because patients with achondroplasia have near-normal life expectancies, the operative shoulder must be functional as well as quite durable in the long term.

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Article Synopsis
  • - A 51-year-old woman who had prior cervical spine surgery faced complications due to hardware failure, leading to an esophageal perforation after the removal of surgical instruments.
  • - An initial attempt to repair the laceration using a rotational flap was unsuccessful, which led to the need for a more complex surgery involving a radial forearm free flap (RFFF) for esophageal reconstruction.
  • - The report emphasizes that treating persistent esophageal perforations is challenging and highlights considerations for choosing between different surgical techniques based on factors like defect size and wound condition.
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Article Synopsis
  • The review highlights the importance of physical activity guidelines and how continuous exercise leads to beneficial molecular adaptations, improving health outcomes.
  • It emphasizes cardiorespiratory fitness and resistance training as key factors in reducing mortality rates and enhancing overall quality of life.
  • The text calls for personalized exercise programs and innovative strategies to encourage community engagement and increased physical activity participation, despite ongoing challenges with cardiovascular diseases and cancer risk.
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Frailty scores impact the outcomes of urgent carotid interventions in acute stroke patients: A comprehensive analysis of risk and prognosis.

J Vasc Surg

December 2024

Section of Vascular/Endovascular Surgery, Department of Surgery, Ochsner Clinic Foundation, New Orleans, LA; The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA. Electronic address:

Article Synopsis
  • Carotid artery disease significantly contributes to ischemic strokes, and urgent carotid interventions such as uCEA and uCAS are critical for at-risk patients, particularly the elderly.
  • A study examined 307 stroke patients to develop a frailty-based risk score that predicts outcomes like stroke, death, and myocardial infarction following these procedures, with comorbidities like hypertension being prevalent.
  • Results showed that higher frailty scores correlate with increased risks post-procedure, emphasizing the need for careful patient selection based on health status and frailty.
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Salvage revisions of atlantoaxial (AA) joint complex posterior segmental instrumented fusion constructs require careful individualized planning to prevent occipital extension. In this case report, we describe the use of bilateral intrafacet spacer placement as a mobility-sparing bailout option for the revision surgery. A 64-year-old male with a history of diffuse idiopathic skeletal hyperostosis, extremely limited baseline cervical mobility, and prior AA posterior segmental instrumented fusion presented with increasing pain at his 6-month follow-up.

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Prolonged fever for more than a week or fever of unknown origin in pediatric patients with or without soft tissue infection should raise suspicion for infection. A 10-year-old female presented to urgent care with a "bug bite" on the left ring finger, cough, and 2 to 3 days of low-grade fever. Ten days later, her symptoms progressed to soft tissue swelling of the left elbow without fracture on radiograph.

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REPLACING THE CHAOS.

Ochsner J

January 2024

Director of Clinical School and Professor, The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA; Editor-in-Chief, Ochsner Journal.

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Article Synopsis
  • The study examines the link between alcohol misuse, as screened by the CAGE questionnaire, and the likelihood of contracting certain sexually transmitted infections (STIs).
  • It found a significant association between higher CAGE scores (≥2) and increased odds of having hepatitis B, gonorrhea, and hepatitis C, indicating that individuals with higher alcohol misuse may be at greater risk for these infections.
  • The findings suggest that patients with a positive CAGE score should be considered for targeted STI screening during their annual check-ups to facilitate early detection and treatment.
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Stumped by a Case of Appendicitis After Appendectomy.

Ochsner J

January 2024

The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA.

Stump appendicitis-a rare, delayed complication of appendectomy-is most commonly managed with surgical exploration and stump appendectomy. Conservative management in the pediatric population is poorly characterized in the literature. We report a case of a 10-year-old male who was diagnosed with stump appendicitis and initially treated nonoperatively.

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Article Synopsis
  • Buprenorphine/naloxone (Suboxone) is recognized as the primary treatment for opioid use disorder (OUD), but until 2023, prescribing it required a special certification (X-Waiver) that limited the number of patients a doctor could treat.
  • The Consolidated Appropriations Act of 2023 removed these restrictions, allowing buprenorphine/naloxone to be prescribed like other opioids, aiming to improve access to treatment for OUD.
  • Despite the legislative changes, further efforts are needed—such as reducing stigma and improving institutional support—to truly enhance the treatment experience and outcomes for patients with OUD.
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Bone-patellar tendon-bone (BPTB) autografts are often used to treat anterior cruciate ligament (ACL) tears in young, highly active patients. These grafts are robust and provide adequate stability, allowing for return to sport and optimal functional outcomes in athletes. Patellar tendon rupture following BPTB ACL reconstruction is rare and can be difficult to treat.

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International Experience of Implementing Cognitive Remediation for People With Psychotic Disorders.

Schizophr Bull

August 2024

Department of Psychiatry, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.

Background: Cognitive remediation (CR) is an effective therapy for the cognitive impact of mental illness, especially schizophrenia. Global efforts are being made to implement CR into routine mental health services with the aim of improving functional outcomes for the population of people recovering from mental illness. Implementation and dissemination of CR in heterogeneous settings require knowledge gleaned from formal implementation research and pragmatic experiential learning.

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