23 results match your criteria: "The University of Palermo[Affiliation]"

Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats.

Biomed Pharmacother

November 2024

Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133, Italy; Navhetec s.r.l., Spinoff of the University of Palermo, Palermo, Italy. Electronic address:

Article Synopsis
  • The study investigates the interaction between plant-derived nanovesicles (PDNVs), particularly lemon-derived nanovesicles (LNVs), and mammalian cells, highlighting their potential to regulate important molecular pathways.
  • It focuses on the antioxidant effects of LNVs and industrial-scale lemon nanovesicles (iLNVs) on healthy human liver cells and rats with metabolic syndrome induced by a high-fat diet, showing a reduction in reactive oxygen species (ROS) production and an increase in antioxidant proteins (Nrf2 and HO-1).
  • The results suggest that iLNVs improve glucose tolerance and lipid metabolism in rats while enhancing overall liver health, positioning LNVs/iLNVs as a potential treatment for
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Some Physiological Effects of Nanofertilizers on Wheat-Aphid Interactions.

Plants (Basel)

July 2023

Department of Biological, Chemical and Pharmacological Sciences and Technology-Botany Section, The University of Palermo, 38-90123 Palermo, Italy.

The increasing use of nanofertilizers in modern agriculture and their impact on crop yield and pest management require further research. In this study, the effects of nano-Fe, -Zn, and -Cu (which are synthesized based on nanochelating technology), and urea (N) fertilizers on the antioxidant activities of wheat plants (cv. Chamran), and the wheat green aphid (Rondani) are investigated.

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Article Synopsis
  • The implantation of Left Ventricular Assist Devices (LVADs) is increasing, but there is limited information on how patients accept these devices and how this affects their quality of life.
  • A study involving 101 patients used questionnaires to evaluate quality of life, anxiety, depression, and device acceptance, finding significant correlations between lower device acceptance and higher psychological distress and poorer quality of life.
  • Results indicated younger patients tended to have lower acceptance and quality of life, suggesting that improving device acceptance could enhance well-being for those receiving LVADs.
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This work demonstrates a new method for investigating time-resolved structural changes in protein conformation and oligomerization photocage-initiated time-resolved X-ray solution scattering by observing the ATP-driven dimerization of the MsbA nucleotide-binding domain. Photocaged small molecules allow the observation of single-turnover reactions of non-naturally photoactivatable proteins. The kinetics of the reaction can be derived from changes in X-ray scattering associated with ATP-binding and subsequent dimerization.

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Professor Caterina Mammina, 1957-2016.

Iran J Microbiol

October 2016

(as representative of graduated Iranian fellows and students who were under supervision of Prof. Caterina Mammina).

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This article describes the history and the prevailing orientations of group psychotherapy in Italy (psychoanalytically oriented, psychodrama, CBT groups) and particularly group analysis. Provided free of charge by the Italian health system, group psychotherapy is growing, but its expansion is patchy. The main pathways of Italian training in the different group psychotherapy orientations are also presented.

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An uncommon presentation of eosinophilic granulomatosis with polyangiitis: a case report.

J Med Case Rep

June 2014

Internal Medicine and Hypertension Unit - Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), P, Giaccone Policlinico of the University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.

Introduction: Eosinophilic granulomatosis with polyangiitis is a rare and potentially fatal disease if not readily diagnosed. Cerebral involvement is extremely rare and clinical presentation as hemorrhagic stroke is even rarer.

Case Presentation: A 58-year-old Caucasian man was admitted to our medical unit because of a computed tomography-diagnosed hemorrhagic stroke with right-sided hemiparesis and fever.

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Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.

J Cardiovasc Med (Hagerstown)

January 2014

aDivision of Cardiology, Department of Internal and Specialist Medicine and Cardiovascular Diseases bPostgraduate School of Cardiology cCentre for the Diagnosis of Preclinical and Multifocal Atherosclerosis and for Cardiovascular Prevention Division of Cardiology, University Hospital 'P. Giaccone', of the University of Palermo, Palermo, Italy dDivision of Nuclear Medicine of 'Civico Benfratelli, G. Di Cristina' Hospital, Palermo, Italy.

Aims: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction.

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Aim: The metabolic syndrome (MS) is associated with increased cardiovascular and cerebrovascular risk. This study aimed to compare the difference of the three established diagnostic criteria of MS, developed by Adult Treatment Panel III (ATP III), American Heart Association (AHA) and National Heart Lung and Blood Institute (NHLBI), and International Diabetes Federation (IDF), with regard to the prevalence of the syndrome and the ability to correctly identify individuals with cardiovascular or cerebrovascular disease or subclinical atherosclerosis.

Methods: We studied 947 consecutive patients underwent clinical evaluation between the 1997-2002.

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This study aimed to make a profile of patients at highest risk of developing contrast induced nephropathy (CIN) in order to take appropriate prevention measures. 591 patients undergoing coronary procedures were divided into two groups: patients with (CIN-group) and without (no-CIN) an increase in creatinine level equal or more than 25% from baseline values within 24-48 h after the coronary procedure. All patients underwent an accurate anamnesis, objective exam, hematochemical measurements, and diagnostic exams.

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Impact of dual antiplatelet therapy with proton pump inhibitors on the outcome of patients with acute coronary syndrome undergoing drug-eluting stent implantation.

ISRN Cardiol

August 2012

Division of Cardiology and Post-Graduate School of Cardiology, Center for the Early Diagnosis of Preclinical and Multifocal Atherosclerosis and for the Secondary Prevention, University Hospital "P. Giaccone" of the University of Palermo, 127-90127 Palermo, Italy.

This study aimed to assess if proton pump inhibitors (PPIs) may reduce the effectiveness of clopidogrel, than H2 antagonist (anti-H2) in order to determine rehospitalization for acute coronary syndrome (re-ACS), target vessel revascularization (TVR) and cardiac death. This case-control study included 176 patients with ACS undergoing angioplasty (PCI) with drug-eluting stent implantation. The population was divided into two groups: PPI group (n = 121) consisting of patients receiving at discharge dual antiplatelet therapy (DAT) plus PPI and anti-H2 group (n = 55), consisting of patients receiving at discharge DAT + H2 receptor antagonist (H2RA).

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Objective: In hypertensive patients with typical chest pain but absence of coronary stenosis the coronary microcirculation may be impaired, thus, our study aimed to appraise, in these subjects, the role of the coronary microcirculation, assessed by Myocardial Blush Grade (MBG) and Thrombolysis in Myocardial Infarction (TIMI) Frame Count (TFC).

Methods: A total of 95 subjects with chest pain and uninjured coronary arteries were recruited into the study: 80 subjects were hypertensive while 15 subjects were normotensive. The hypertensive subjects were divided into two subgroups: hypertensive subjects with positive scintigraphy and hypertensive subjects with negative scintigraphy.

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An update on the role of markers of inflammation in atherosclerosis.

J Atheroscler Thromb

February 2010

Chair of Cardiovascular Diseases, Division of Cardiology & Post-Graduate School of Cardiology, University Hospital Paolo Giaccone of the University of Palermo, Italy.

In recent years, several studies have used the measurement of carotid intima-media thickness (IMT) as a marker of early atherosclerosis: IMT has been shown to correlate significantly with the presence of coronary artery disease (CAD) and to predict fatal and not fatal cerebro- and cardio-vascular events. These findings highlight the importance of recognizing and managing early stages of atherosclerosis for effective cardiovascular prevention. Beyond traditional established cardiovascular risk factors, inflammation has been shown to be crucial throughout atherosclerosis from endothelial dysfunction to plaque rupture and thrombosis.

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Background: Recent guidelines published by the joint European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but few data are available on the role of CRP in patients with carotid lesions.

Methods: We studied 472 patients, 236 with and 236 without hypertension, sex- and age-matched, with and without early stages of atherosclerosis (e.g.

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Background: The purpose of this study was to investigate whether the vasodilator response to brachial artery and the presence of carotid lesions may have a prognostic significance in patients with early stages of atherosclerosis.

Methods And Results: Vascular echography was performed to analyze flow-mediated vasodilatation (FMD) at the brachial artery and intima-media thickness (IMT) of carotid arteries in 84 asymptomatic patients. At baseline, we evaluated all the established traditional cardiovascular risk factors.

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Peripheral artery disease: potential role of ACE-inhibitor therapy.

Vasc Health Risk Manag

April 2009

Department of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, University Hospital P. Giaccone of the University of Palermo, Via del Vespro 127, Palermo, Italy.

Subjects with peripheral arterial disease (PAD) of the lower limbs are at high risk for cardiovascular and cerebrovascular events and the prevalence of coronary artery disease in such patients is elevated. Recent studies have shown that regular use of cardiovascular medications, such as therapeutic and preventive agents for PAD patients, seems to be promising in reducing long-term mortality and morbidity. The angiotensin-converting-enzyme (ACE) system plays an important role in the pathogenesis and progression of atherosclerosis, and ACE-inhibitors (ACE-I) seem to have vasculoprotective and antiproliferative effects as well as a direct anti-atherogenic effect.

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Role of inflammation and infection in vascular disease.

Acta Chir Belg

April 2006

Division of Cardiology & post-graduate School of Cardiology, Department of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, University Hospital Paolo Giaccone of the University of Palermo, Italy.

Relationship of infection, inflammation, and atherosclerosis has been a subject of intensive investigation in recent years. Potential mechanisms whereby chronic infections may play a role in atherogenesis are myriad. Chlamydia pneumoniae (Cp) infection in early life may accelerate atherosclerosis, leading to cardiovascular complications.

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Innervated island flaps in morphofunctional vulvar reconstruction.

Plast Reconstr Surg

April 2000

Service of Plastic and Reconstructive Surgery, School of Medicine, at the University of Palermo, Italy.

In this article, the authors present their own experience in vulvar reconstruction following vulvectomy using two different innervated island flaps according to the size and site of the defect. Island-flap mobilization is possible thanks to the rich blood supply of the perineal region. The methods described are a "V-Y amplified sliding flap from the pubis" and a "fasciocutaneous island flap" raised from one or both gluteal folds.

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A new extended external oblique musculocutaneous flap for reconstruction of large chest-wall defects.

Plast Reconstr Surg

April 1999

Service of Plastic and Reconstructive Surgery, School of Medicine, at the University of Palermo, Italy.

A new extended external oblique musculocutaneous flap utilized in the reconstruction of chest-wall defects is described. The flap is drawn as a V-Y rotation flap on the ipsilateral abdominal wall. It is laterally based, and its pedicle coincides with the five lowest costal insertions of the external oblique.

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