3,023 results match your criteria: "The University of Oklahoma[Affiliation]"

Thioredoxin-1 protein interactions in neuronal survival and neurodegeneration.

Biochim Biophys Acta Mol Basis Dis

January 2025

Department of Physiology and Pathophysiology, University of Manitoba, Canada. Electronic address:

Neuronal cell death remains the principal pathophysiologic hallmark of neurodegenerative diseases and the main challenge for treatment strategies. Thioredoxin1 (Trx1) is a major cytoplasmic thiol oxidoreductase protein involved in redox signaling, hence a crucial player in maintaining neuronal health. Trx1 levels are notably reduced in neurodegenerative diseases including Alzheimer's and Parkinson's diseases, however, the impact of this decrease on neuronal physiology remains largely unexplored.

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  • The study develops an explainable AI system using Natural Language Processing (NLP) to match patients with phase 1 oncology clinical trials, aiming to improve recruitment efficiency for drug development.
  • The prototype considers four key matching criteria: cancer type, performance status, genetic mutation, and measurable disease, and delivers a matching score with explanations of the results.
  • Evaluations against expert matching revealed the system's performance metrics (73.68% precision, 56% recall, 77.78% accuracy, 89.36% specificity) and highlighted issues like abbreviation ambiguity and context misunderstanding as error factors, making it a unique approach in the public domain for this purpose.
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Design of thermally programmable 3D shape memory polymer-based devices tailored for endovascular treatment of intracranial aneurysms.

J Mech Behav Biomed Mater

December 2024

Department of Bioengineering, University of California Riverside, Riverside, CA, USA; Stephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA. Electronic address:

Despite recent technological advancements in endovascular embolization devices for treating intracranial aneurysms (ICAs), incomplete occlusion and aneurysm recanalization remain critical challenges. Shape memory polymer (SMP)-based devices, which can be manufactured and tailored to patient-specific aneurysm geometries, possess the potential to overcome the suboptimal treatment outcome of the gold standard: endovascular coiling. In this work, we propose a highly porous patient-specific SMP embolic device fabricated via 3D printing to optimize aneurysm occlusion, and thus, improve the long-term efficacy of endovascular treatment.

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Cancer represents one of the diseases with the highest mortality rate worldwide. The burden of cancer continues to increase, not only affecting the health-related quality of life of patients but also causing an elevated global financial impact. The complexity and heterogeneity of cancer pose significant challenges in research and clinical practice, contributing to increase the failure rate of clinical trials for antitumoral drugs.

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LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential.

Cancer Lett

November 2024

Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

Article Synopsis
  • * When lncRNAs are dysregulated, they can either promote cancer as oncogenes or inhibit it as tumor suppressors, affecting tumor progression and characteristics like metastasis and chemoresistance.
  • * The review emphasizes the need to understand lncRNAs' roles in cancer to develop new therapeutic strategies and enhance precision medicine approaches in treating cancer patients.
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  • The study evaluates the impact of early discontinuation of aspirin in favor of ticagrelor monotherapy on bleeding and ischemic events in patients who underwent percutaneous coronary intervention (PCI).
  • Results show that while ticagrelor monotherapy led to significantly fewer bleeding events compared to ticagrelor plus aspirin, the total ischemic events remained similar between the two groups.
  • Overall, among high-risk PCI patients, ticagrelor alone was associated with reduced bleeding without increasing the risk of ischemic complications.
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Psychiatric outcomes are commonly observed in individuals with repeated concussions, though their underlying mechanism is unknown. One potential mechanism linking concussion with psychiatric symptoms is inflammation-induced activation of the kynurenine pathway, which is thought to play a role in the pathogenesis of mood disorders. Here, we investigated the association of prior concussion with multiple psychiatric-related outcomes in otherwise healthy male and female collegiate-aged athletes (N = 212) with varying histories of concussion recruited from the community.

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The tutelage of our mentors as scientists included the analogy that writing a good scientific paper was an exercise in storytelling that omitted unessential details that did not move the story forward or that detracted from the overall message. However, the advice to not get lost in the details had an important flaw. In science, it is the many details of the data themselves and the methods used to generate and analyze them that give conclusions their probative meaning.

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Background: Satisfaction with birth and healthcare provider experiences have long-term effects for maternal health. Research has shown that mothers who report more trust, respect, and self-efficacy in their relationship with their healthcare providers are more likely to report positive birthing experiences. Further, individuals with obesity, including pregnant mothers, are more likely to experience weight-related stigma from healthcare providers which may negatively impact satisfaction with this relationship.

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Targeting the Hippo pathway in Schwann cells ameliorates peripheral nerve degeneration via a polypharmacological mechanism.

Neurotherapeutics

October 2024

Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan 49201, South Korea. Electronic address:

Article Synopsis
  • Peripheral neuropathies (PNs) affect elderly individuals and are linked to Schwann cell dysfunction and irreversible Wallerian degeneration (WD), with few therapeutic options available.
  • The study explored the effects of the chemical inhibitor XMU-MP-1 (XMU) on WD, finding that it inhibited the harmful processes in Schwann cells across multiple research models.
  • The research highlights the involvement of the Hippo/MST pathway and suggests that XMU could serve as a new multitargeted treatment strategy for elderly patients suffering from PNs.
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The advent of generative Large Language Models (LLMs) has greatly impacted the field of Natural Language Processing. However, it is inconclusive how generative LLMs perform on domain-specific information extraction tasks. This study compares the performance of GPT-4 and a rule-based information extraction method based on ChemDataExtractor on band gap information extraction, a task that has important implications for the materials science domain.

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  • Intravenous lipids are important for very premature babies to get the nutrition they need safely.
  • The study compared two kinds of intravenous fats: one made with fish oil (CO-ILE) and another made with only soybean oil (SOLE), to see which was better for babies needing long-term nutrition.
  • Results showed that CO-ILE had a lower chance of causing liver problems and less yellowing of the skin compared to SOLE, suggesting CO-ILE might be a safer choice for these babies.
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To reduce the CO release in the atmosphere, the carbon capture and sequestration (CCS) technique presents a solution in which the CO is captured from the emitting source and injected into a suitable geological formation in the subsurface. For the CCS project to be successful, CO must be trapped underground for hundreds of years. In that respect, good integrity plays an important role as it ensures that the injected CO remains sequestrated in the subsurface.

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Introduction: Chronic kidney disease (CKD) is more prevalent among veterans in the United States than in the general population. Similarly, veterans also exhibit higher rates of abnormal sleep duration compared to the general population. The aim of this study was to investigate the association between self-reported length of sleep and the prevalence of CKD among veterans in the United States using responses from the 2022 Behavioral Risk Factor Surveillance System (BRFSS).

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  • Near-rigid-body grain rotation is significant during processes like grain growth, recrystallization, and plastic deformation in nanocrystalline materials, but its mechanisms have been unclear for decades.
  • New evidence shows that grain rotation happens due to the movement of disconnections along grain boundaries in platinum thin films.
  • Advanced microscopy techniques reveal a statistical link between grain rotation and changes in grain size, highlighting the role of shear-coupled grain boundary migration in this phenomenon.
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Background: Approximately 1.4 vascular surgeons/100,000 persons are estimated to fulfill current patient needs in the United States (US), but an ongoing shortage exists. The aims of this study are to provide an updated nationwide state-by-state workforce analysis and compare the distribution of practicing vascular surgeons and training opportunities.

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Reducing the particles generated by flushing institutional toilets. Part II: Assessing a portable and reusable toilet cover in U.S. hospitals.

J Occup Environ Hyg

December 2024

Department of Occupational and Environmental Health, Hudson College of Public Health, The University of Oklahoma Health Sciences Center, The University of Oklahoma, Oklahoma City, Oklahoma.

Flushing uncovered toilets in hospitals has been shown to produce toilet plume aerosols (TPA) in a wide size ranging from nanometers to micrometers. Studies have shown that TPA can carry infectious pathogens and hazardous drugs used in cancer treatment. To mitigate the risk of exposure, some researchers have recommended covering the toilet during flushing, and guidelines from the Oncology Nursing Society have specifically recommended covering the toilet when flushing excreta from patients receiving chemotherapy.

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Montelukast deprescribing in outpatient specialty clinics: A single center cross-sectional study.

Explor Res Clin Soc Pharm

December 2024

Department of Pharmacy: Clinical and Administrative Sciences, The University of Oklahoma Health Sciences College of Pharmacy, 1110 N Stonewall Ave, CPB 239, Oklahoma City, OK 73117, United States of America.

Article Synopsis
  • The study looked at how often doctors stop patients from taking a medicine called montelukast in special clinics.
  • Out of 1152 patients, only 43 (or about 3.7%) had their montelukast stopped, with reasons like side effects and discussions with doctors.
  • The results showed that stopping montelukast doesn't happen very often, and more research is needed to understand why that is.
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  • A study was conducted on ventilator-associated tracheitis or pneumonia in mechanically ventilated children using inhaled tobramycin at specific intervals to assess drug levels and kidney function.
  • The main goal was to find how many patients had tobramycin levels above 0.5 µg/mL, while secondary goals included comparing patient characteristics and tracking any instances of acute kidney injury (AKI).
  • Out of 44 patients studied, 68% had detectable drug levels and 20.5% experienced AKI, but no significant differences were found in demographics or medical details between those with and without detectable levels or AKI.
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Prostate cancer disproportionately affects Black men in the United States, leading to higher mortality rates and health disparities. In addition, based on historical mistreatment and discrimination and the resulting distrust of the medical system, Black populations are consistently underrepresented in health care-related research. Addressing these challenges requires community-driven approaches integrating diverse perspectives and fostering equitable health outcomes.

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The objective of this paper was to assess hospitalizations and health resource utilization associated with diabetic foot infection (DFI)-related visits within emergency departments (EDs) in the U.S. This nationally representative, cross-sectional historical cohort utilized the Centers for Disease Control and Prevention's (CDC's) National Hospital Ambulatory Medical Care Survey across a ten-year period from 2012 to 2021.

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Despite growing recognition, neuropsychiatric diseases associated with infections are a major unsolved problem worldwide. Group A streptococcal (GAS) infections can cause autoimmune sequelae characterized by movement disorders, such as Sydenham chorea, and neuropsychiatric disorders. The molecular mechanisms underlying these diseases are not fully understood.

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AESurv: autoencoder survival analysis for accurate early prediction of coronary heart disease.

Brief Bioinform

September 2024

Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles (UCLA), 650 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.

Article Synopsis
  • Coronary heart disease (CHD) is a major health issue in the U.S., and improved prediction models could help in early detection and intervention.
  • Researchers developed a deep learning autoencoder survival analysis model (AESurv) that analyzes DNA methylation and clinical data to predict CHD events more accurately.
  • The AESurv model outperformed traditional survival analysis models in two studies, showing strong potential for improving early CHD prediction and aiding healthcare professionals in managing patient care.
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