6 results match your criteria: "The University of North Carolina at Greensboro Greensboro[Affiliation]"
The drastic increase among the U.S. unemployment rate led to increased trauma among those who lost their job as a result of the global COVID-19 pandemic.
View Article and Find Full Text PDFPhotodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.
Am J Cancer Res
January 2022
Department of Microbiology & Immunology, Dalhousie University Halifax, Nova Scotia B3H 1X5, Canada.
Article Synopsis
- Cancer therapies that trigger T cell responses are increasingly preferred over traditional treatments, particularly through a process called immunogenic cell death (ICD), which enhances the immune system's ability to recognize and attack tumors.
- Recent research has focused on developing novel photodynamic therapy (PDT) compounds, specifically two ruthenium-based compounds, ML19B01 and ML19B02, which can be activated by near infrared light to not only kill cancer cells but also stimulate immune responses.
- The study found that these PDT treatments led to the expression of key proteins associated with ICD, facilitating the activation of immune cells and resulting in anti-tumor immunity in mouse models against melanoma, demonstrating their potential for effective cancer immunotherapy.
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Chem Sci
November 2020
Department of Chemistry and Biochemistry, The University of Texas at Arlington Arlington Texas 76019-0065 USA
Article Synopsis
- Over the last 20 years, photodynamic therapy (PDT) has shown potential not just as a local cancer treatment, but also for triggering a systemic immune response that helps prevent tumor recurrence, particularly in aggressive cancers like melanoma.
- Researchers have developed nine new near-infrared (NIR) photosensitizers (PSs) based on a specific chemical structure that demonstrate strong effectiveness against melanoma cells, achieving low concentrations for significant phototoxic effects with NIR light.
- When tested in mice, PDT treatment with one of the PSs activated a pro-inflammatory response and induced immunogenic cell death, resulting in substantial protection from tumor growth and improved survival rates after vaccination and subsequent tumor challenges.
Maternal emotional support but not cognitive support during problem-solving predicts increases in cognitive flexibility in early childhood.
Int J Behav Dev
January 2019
Department of Human Development and Family Studies, The University of North Carolina at Greensboro Greensboro, NC 27402.
Many local scale studies have shown that bats respond to water quality degradation or urbanization in a species-specific manner. However, few have separated the effects of urbanization versus water quality degradation on bats, in single city or single watershed case studies. Across North Carolina, USA, we used the standardized North American Bat Monitoring Program mobile transect protocol to survey bat activity in 2015 and 2016 at 41 sites.
View Article and Find Full Text PDFInfant Hand Preference and the Development of Cognitive Abilities.
Front Psychol
April 2016
Department of Physical Therapy, University of Delaware Newark, NJ, USA.
Article Synopsis
- Hand preference begins to develop in infants within their first two years, with about half showing a consistent preference for using one hand, particularly when acquiring objects.
- By the end of their second year, most children display a consistent hand preference that affects how they use both hands together for various tasks.
- These differences in hand usage are linked to variations in brain development and cognitive abilities, with children who establish a clear hand preference early on showing advanced skills in language, object manipulation, and tool use compared to those with a later preference.