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6,832 results match your criteria: "The University of North Carolina At Chapel Hill[Affiliation]"
bioRxiv
November 2024
Department of Psychiatry, The University of North Carolina at Chapel Hill.
'Biological aging clocks' - composite molecular markers thought to capture an individual's biological age - have been traditionally developed through bulk-level analyses of mixed cells and tissues. However, recent evidence highlights the importance of gaining single-cell-level insights into the aging process. Microglia are key immune cells in the brain shown to adapt functionally in aging and disease.
View Article and Find Full Text PDFNeurooncol Adv
October 2024
Caris Life Sciences, Medical Affairs, Phoenix, Arizona, USA.
Background: High-grade gliomas (HGGs) are the most aggressive type of gliomas and have the poorest outcomes. Chromatin remodeling (CR) genes have been implicated in multiple oncogenic pathways in numerous cancer types. In gliomagenesis, CR genes have been implicated in regulating the stemness of glioma cells, the tumor microenvironment (TME), and resistance to therapies.
View Article and Find Full Text PDFHernia
November 2024
Department of Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Introduction: Abdominal binders consist of a wide compression belt that encircles the abdomen, theoretically supporting the abdominal wall. However, their use after ventral hernia repair is debated. Therefore, this meta-analysis evaluates their efficacy.
View Article and Find Full Text PDFHealth Promot Pract
November 2024
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Low racial/ethnic diversity among public health academics undermines our research, teaching, and practice. One important step for addressing this problem is to increase the diversity of applicant pools for open faculty positions. In this commentary, we share our experience conducting a tenure-track faculty search at a large public university.
View Article and Find Full Text PDFBioeng Transl Med
November 2024
Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Glioblastoma (GBM) is the most common primary malignant brain tumor diagnosed in adults, carrying with it an extremely poor prognosis and limited options for effective treatment. Various cell therapies have emerged as promising candidates for GBM treatment but fail in the clinic due to poor tumor trafficking, poor transplantation efficiency, and high systemic toxicity. In this study, we design, characterize, and test a 3D-printed cell delivery platform that can enhance the survival of therapeutic cells implanted in the GBM resection cavity.
View Article and Find Full Text PDFBody Image
December 2024
Division of Applied Psychology, School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, PR China.
ACS EST Air
November 2024
Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Fires at the wildland-urban interface (WUI) are increasing in magnitude and frequency, emitting organic aerosol (OA) with unknown composition and atmospheric impacts. In this study, we investigated the chemical composition of OA produced through the 600 °C pyrolysis of ten urban materials in nitrogen, which were subsequently aged under UV light for 2 h. The analysis utilized ultrahigh-performance liquid chromatography (UHPLC) separation, coupled with a photodiode array (PDA) detector and a high-resolution mass spectrometer (HRMS) for molecular characterization.
View Article and Find Full Text PDFBMJ Open Qual
November 2024
Department of Anesthesiology, University of California Davis, Davis, California, USA.
Sci Adv
November 2024
Department of Applied Physical Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Fast and accurate assessment of skin mechanics holds great promise in diagnosing various epidermal diseases, yet substantial challenges remain in developing simple and wearable strategies for continuous monitoring. Here, we present a design concept, named active near-infrared spectroscopy patch (ANIRP) for continuously mapping skin mechanics. ANIRP addresses these challenges by integrating near-infrared (NIR) sensing with mechanical actuators, enabling rapid measurement (<1 s) of Young's modulus, high spatial sensing density (~1 cm), and high spatial sensitivity (<1 mm).
View Article and Find Full Text PDFThe Duke University Clinical and Translational Science Institute Community Engaged Research Initiative (CERI) created an e-Library in 2018. This e-Library was developed in response to requests from academic researchers and the community for reliable, easily accessible information about community-engaged research approaches and concepts. It was vetted by internal and external partners.
View Article and Find Full Text PDFBMJ Case Rep
November 2024
Family Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
A woman in her 30s presented with a 3-day history of nausea, vomiting and abdominal pain. She was found to be in ketoacidosis with an elevated serum glucose level of 18.2 mmol/L (328 mg/dL).
View Article and Find Full Text PDFInt J Eat Disord
November 2024
Division of Adolescent & Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California, USA.
Objective: This study examined cross-sectional and longitudinal associations of intermittent fasting (IF) engagement with body mass index (BMI), both thinness-oriented and muscularity-oriented eating disorder (ED) psychopathology, eating-related psychosocial impairment, and intuitive eating.
Method: Using a longitudinal design, 491 Chinese adults (M = 30.33 years, SD = 7.
Endoscopy
November 2024
Gastroenterology and Hepatology, Virginia Mason Medical Center, Seattle, United States.
Background: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a minimally invasive technique for treating gastric outlet obstruction (GOO). The aim of this study was to assess the outcomes of EUS-GE in managing benign GOO caused by duodenal stenosis in patients with acute pancreatitis.
Methods: This international retrospective study analyzed patients treated with EUS-GE for GOO caused by acute pancreatitis until December 2023, evaluating technical and clinical success, adverse events, and reintervention.
J Diabetes Sci Technol
January 2025
Department of Nutrition, UNC Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: The number of older adults with type 1 diabetes (T1D) is increasing. Use of automated insulin delivery (AID) may influence nutrition and eating behaviors. We explored how three eating styles (restrained, external, emotional) differ between older adults with T1D who use and do not use AID.
View Article and Find Full Text PDFOsteoarthritis Cartilage
November 2024
Joint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Raleigh, NC 27695, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA; Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
Objective: Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries are only partial; yet, there is limited data to inform clinical treatment of such partial tears. It is unknown how injury partial injury impacts long-term degenerative changes in the joint relative to complete injury.
View Article and Find Full Text PDFJ Addict Med
November 2024
From the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC (ESK); Addiction Medical Services of Wisconsin, Onalaska, WI (CWS); Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, NC (JLC); and Horizons Division and Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, and Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology, School of Medicine, Johns Hopkins University, Baltimore, MD (HEJ).
Objectives: Inhalants are often used for their psychoactive effects, producing feelings of euphoria. Inhalant and solvent use is a serious public health concern, yet little is known about their effects on perinatal, fetal, and child outcomes. The aim of our review is to evaluate the impact of inhalant use by pregnant people on maternal, fetal, neonatal, and early childhood outcomes.
View Article and Find Full Text PDFUrogynecology (Phila)
November 2024
From the Division of Urogynecology, Department of Obstetrics & Gynecology, Alpert Medical School of Brown University, Providence, RI.
Importance: There is limited evidence guiding surgeons in how much mesh to resect when treating mesh complications.
Objective: The aim of the study was to compare rates of recurrent prolapse after mesh excisional surgical procedures for prolapse mesh complications.
Study Design: This multicenter, retrospective cohort study included patients, identified by Current Procedural Terminology codes, who were treated surgically for prolapse mesh complications at 8 institutions between 2010 and 2019.
Prev Sci
November 2024
Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Theoretical models and empirical research have highlighted the impact of economic disadvantage on children's psychosocial development broadly and the onset, maintenance, and treatment of early-onset (3-8 years) behavior disorders (BDs) more specifically. In the context of intervention, evidence suggests that economic disadvantage may pose risk for diminished parent-mediated treatment efficacy (e.g.
View Article and Find Full Text PDFTher Adv Infect Dis
November 2024
Department of Environmental Sciences and Engineering, the University of North Carolina at Chapel Hill, 0300 Michael Hooker Research Center, 135 Dauer Drive, Campus Box # 7431, Chapel Hill, NC 27599, USA.
Background: Malaria during pregnancy contributes to significant perinatal morbidity and mortality, accounting for almost 25% of global maternal mortality. However, the epidemiology and risk factors for subclinical malaria among pregnant women living in refugee settlements is poorly understood.
Objective: To determine the prevalence and predictors of subclinical malaria among pregnant women in refugee settlements in Northern Uganda.
Body Image
December 2024
Division of Applied Psychology, School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. Electronic address:
Prior research demonstrates positive associations between muscularity dissatisfaction and an array of negative health outcomes, including muscularity-oriented disordered eating, eating-related psychosocial impairment, and psychological distress. However, muscularity dissatisfaction differs by gender and is not always linked to these outcomes, indicating the existence of moderators of these associations. We proposed and examined muscularity bias internalization (MBI) as a moderator of these associations.
View Article and Find Full Text PDFEnviron Entomol
November 2024
Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Climate change has been repeatedly linked to phenological shifts in many taxa, but the factors that drive variation in phenological sensitivity remain unclear. For example, relatively little is known about phenological responses in areas that have not exhibited a consistent warming trend, making it difficult to project phenological responses in response to future climate scenarios for these regions. We used an extensive community science dataset to examine changes in the adult flight onset dates of 38 butterfly species with interannual variation in spring temperatures in the Piedmont region of North Carolina, a region that did not experience a significant overall warming trend in the second half of the 20th century.
View Article and Find Full Text PDFArch Womens Ment Health
November 2024
School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Infus Nurs
November 2024
Author Affiliations: Department of Implementation Science (Huffman and Munn), Center for Experiential and Applied Learning (Saunders), and Department of Biostatistics and Data Science (Russell), Wake Forest University School of Medicine (Gonzales), Winston-Salem, North Carolina; Center for Nursing Research (Huffman) and Comprehensive Cancer Center (Butcher), Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina; Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina (Hampton).
Critical care nurses are faced with increasing task loads due to increasing patient complexity. In addition to this complexity, most critical care patients have a maze of infusion and monitoring lines that must be navigated when administering medications. Task load is escalated when a nurse must identify an injection port and administer a medication rapidly.
View Article and Find Full Text PDFGenetics
November 2024
Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Simulations are an essential tool in all areas of population genetic research, used in tasks such as the validation of theoretical analysis and the study of complex evolutionary models. Forward-in-time simulations are especially flexible, allowing for various types of natural selection, complex genetic architectures, and non-Wright-Fisher dynamics. However, their intense computational requirements can be prohibitive to simulating large populations and genomes.
View Article and Find Full Text PDFGeosci Model Dev
September 2024
Institute for the Environment, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The Community Multiscale Air Quality Model (CMAQ) is a local- to hemispheric-scale numerical air quality modeling system developed by the U.S. Environmental Protection Agency (USEPA) and supported by the Community Modeling and Analysis System (CMAS) center.
View Article and Find Full Text PDF