The perspectives of people living with dementia and their carers on the role of the general practice nurse in dementia care provision: a qualitative study.

Background Models that optimise the role of the general practice nurse have the potential to deliver cost-effective best-practice dementia care in the primary care setting. Patient experience is recognised as a vital contribution to the design, provision and evaluation of healthcare services. The aim of this study was to gain insights into the healthcare needs and experiences of people living with dementia and carers as relevant to the provision of dementia care by general practice nurses.

Antimony-bearing schwertmannite transformation to goethite: A driver of antimony mobilization in acid mine drainage.

Antimony(V) mobility in acid mine drainage (AMD) is often controlled by sorption and coprecipitation with schwertmannite - a poorly-ordered Fe(III) oxyhydroxysulfate mineral. However, due to its metastable nature, schwertmannite transforms over time to more thermodynamically stable Fe(III) phases, such as goethite. This study examines how transformation of Sb(V)-bearing schwertmannite to goethite impacts Sb(V) mobility, while also assessing the role that Sb(V) may play in stabilizing schwertmannite against such transformation.

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.

Forecasted increases in the prevalence and severity of extreme weather events accompanying changes in climatic behavior pose potential risk to the reproductive capacity of humans and animals of ecological and agricultural significance. While several studies have revealed that heat stress induced by challenges such as testicular insulation can elicit a marked negative effect on the male reproductive system, and particularly the production of spermatozoa, less is known about the immediate impact on male reproductive function following subchronic whole-body exposure to elevated ambient temperature. To address this knowledge gap, we exposed unrestrained male mice to heat stress conditions that emulate a heat wave (daily cycle of 8 h at 35 °C followed by 16 h at 25 °C) for a period of 7 d.

A metabolomic analysis on the toxicological effects of the universal solvent, dimethyl sulfoxide.

Dimethyl sulfoxide (DMSO) is a solvent used to dissolve a variety of organic compounds. It is presumed to be non-toxic at concentrations below 1 % v/v, although several studies have demonstrated that low dose DMSO exposure can alter cellular biochemistry. This study evaluated the toxicity of DMSO at 0.

DPYD genotype-guided dose personalisation for fluoropyrimidine-based chemotherapy prescribing in solid organ cancer patients in Australia: GeneScreen 5-FU study protocol.

Background: Fluoropyrimidine (FP) chemotherapies are commonly prescribed for upper and lower gastrointestinal, breast and head and neck malignancies. Over 16,000 people with cancer require FP chemotherapies per annum in Australia. Between 10 and 40% patients experience grade 3-4 (≥ G3) toxicities that require hospital-based management ± intensive care admission.

Beyond the random phase approximation (RPA): First principles calculation of the valence EELS spectrum for KBr including local field, quasiparticle, excitonic and spin orbit coupling effects.

The low energy region (< 50 eV) of the electron energy loss spectrum (EELS) can contain a great deal of spectral detail associated with excitations of the valence electrons. Calculation of the spectra from first principles can assist with interpretation and the most widely used method is the random phase approximation (RPA), usually neglecting local field effects (LFE). For KBr this approach is insufficient due to the importance of quasiparticle and excitonic effects.

Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii.

This untargeted metabolomics study investigated the synergistic antibacterial activity of polymyxin B and Leu-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis. Checkerboard microdilution assays revealed a significant synergy against polymyxin-susceptible and -resistant A. baumannii, excluding lipopolysaccharide-deficient variants.

Pre-emergence herbicides used in urban and agricultural settings: dissipation and ecological implications.

Herbicides are widely recognized as the most cost-effective solution for weed control, but their extensive use in both urban and agricultural settings raise serious concerns about nontarget effects. We assessed the possible hazards associated with pre-emergence herbicides such as dimethenamid-P, metazachlor, and pyroxasulfone, which are frequently applied in both urban and agricultural soils. The dissipation rate constant values (k day: 0.

Microalgae-microplastics interactions at environmentally relevant concentrations: Implications toward ecology, bioeconomy, and UN SDGs.

Microplastics (MPs) are one of the emerging pollutants, causing potential harm to aquatic ecosystems and serious concern in achieving UN Sustainable Development Goals (SDGs). Realizing the occurrence of varying concentrations of MPs in the environment, this investigation presents multi-dimensional insights into the ecological and bioeconomic implications at environmentally relevant concentrations. We pursued a multi-step approach to gain a comprehensive understanding on the effects of microalgae‒MPs interactions and their expansive implications toward SDGs.

Dual function of sea grapes (Caulerpa racemosa) as phytoremediator for palm oil mill effluent and as ornamental fish feed formulation.

Phytoremediation is a promising technology for treating Palm Oil Mill Effluent (POME). Moreover, phytoremediators have the potential for various aplication, including as feedstock. Hence, this study aims to elucidate the ability of sea grapes (Caulerpa racemosa) in remediating POME and evaluate their suitability as ornamental fish feed.

Antimony(V) sorption and coprecipitation with ferrihydrite: An examination of retention mechanisms and the selectivity of commonly-applied extraction procedures.

We investigated the mechanisms that control Sb(V) sorption and coprecipitation with ferrihydrite across a range of Sb(V) loadings, and examined the associated effects on Sb(V) extractability during the commonly-applied 1 M HCl extraction scheme and the BCR and Wenzel sequential extraction schemes. EXAFS spectroscopy reveals that Sb(V) sorption and coprecipitation mainly involved Sb(V) incorporation into the ferrihydrite structure via edge sharing and double-corner sharing between SbO and FeO octahedra. Large amounts of these linkages partially stabilized ferrihydrite against extraction with 1 M HCl.

Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord.

Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information from the body. The existence and function of a substantial axon collateral network, also arising from PNs and remaining within the spinal cord, is less well appreciated. Here we use a retrograde viral transduction strategy to characterise a novel subpopulation of deep dorsal horn spinoparabrachial neurons.

Experimental Realization of Fluoroborophene.

Borophene, an anisotropic metallic Dirac material exhibits superlative physical and chemical properties. While the lack of bandgap restricts its electronic chip applications, insufficient charge carrier density and electrochemical/catalytically active sites, restricts its energy storage and catalysis applications. Fluorination of borophene can induce bandgap and yield local electron injection within its crystallographic lattice.

"SHIELDing" Our Educators: Comprehensive Coping Strategies for Teacher Occupational Well-Being.

Background: Teaching is a physically and mentally challenging profession that demands high emotional involvement, often leading to stress and anxiety. Understanding how teachers cope with these demands is essential for enhancing their well-being and effectiveness.

Objectives: This study aimed to (1) investigate personal and school-based well-being initiatives that teachers use for maintaining their occupational well-being, and (2) develop a coping strategy model that enhances teachers' occupational well-being.

Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions.

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in various products, including food packaging, textiles, and firefighting foam, owing to their unique properties such as amphiphilicity and strong CF bonds. Despite their widespread use, concerns have arisen due to their resistance to degradation and propensity for bioaccumulation in both environmental and human systems. Emerging evidence suggests a potential link between PFAS exposure and neurotoxic effects, spanning cognitive deficits, neurodevelopmental disorders, and neurodegenerative diseases.

Registrars as teachers: a qualitative study exploring the experiences of Australian general practice registrars in teaching roles.

Background: GP registrars (specialist vocational trainees in general practice) are interested in teaching, and there are considerable benefits to teaching during training. There are, however, significant barriers for registrars as teachers, including inadequate funding, time pressures, and limited teacher training. Current evidence does not include medical educator (ME) perspectives or compare teaching settings (e.

Effectiveness of psychoeducation interventions for pregnant women with gestational diabetes mellitus: an integrative review.

Background: Gestational diabetes mellitus occurs in approximately 15-17% of pregnant women worldwide and causes high mortality and morbidity for mothers and infants. Pregnant women who are newly diagnosed with gestational diabetes mellitus experience higher levels of stress and anxiety than pregnant women without this condition. Thus, it is important to identify effective interventions to help pregnant women cope with the additional stress and anxiety associated with pregnancy-related complications.

Temporal trends in the prevalence of GP registrars' long-term paediatric asthma control medications prescription.

Asthma is one of the most common chronic illnesses affecting children. Long-term asthma control medications (LTACMs) are an important aspect of asthma management, with under-prescription associated with poor asthma control and increased asthma deaths. This study aimed to document temporal trends in the prescribing of LTACMs for paediatric patients for asthma-related presentations to Australian general practice registrars (trainees).

Creating Spin Channels in SrCoO through Trigonal-to-Cubic Structural Transformation for Enhanced Oxygen Evolution/Reduction Reactions.

Oxygen evolution and reduction reactions (OER and ORR) play crucial roles in energy conversion processes such as water splitting and air batteries, where spin dynamics inherently influence their efficiency. However, the specific contribution of spin has yet to be fully understood. In this study, we intentionally introduce a spin channel through the transformation of trigonal antiferromagnetic SrCoO into cubic ferromagnetic SrCoO, aiming to deepen our understanding of spin dynamics in catalytic reactions.

Do Personalized Nutrition Interventions Improve Dietary Intake and Risk Factors in Adults With Elevated Cardiovascular Disease Risk Factors? A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Context: Dietary modifications can improve cardiovascular disease (CVD) risk factors. Personalized nutrition (PN) refers to individualized nutrition care based on genetic, phenotypic, medical, behavioral, and/or lifestyle characteristics. PN may be beneficial in improving CVD risk factors, including diet.