High-fat-sugar diet is associated with impaired hippocampus-dependent memory in humans.

Overconsumption of high-fat and high-sugar (HFS) diet may affect the hippocampus, and consequently, memory functions. Yet, converging evidence is needed to demonstrate that the type of memory affected by HFS diet consumption is indeed hippocampus dependent. Moreover, the extent to which HFS diet can also affect executive functioning, and indirectly affect memory requires further examination.

How Should We Respond to Racist Legacies in Health Professions Education Originating in the Flexner Report?

The Flexner Report damaged and marginalized historically Black medical schools, which today produce more than their fair share of Black medical graduates. As physicians, graduates of Black medical schools have confronted head-on the inequities of American responses to COVID-19 that the pandemic has laid bare to the world. Black physicians' leadership roles in American health care and in American communities have informed the reimagination of health care and medical education as just and inclusive.

Streets, strolls and spots: sex work, drug use and social space in Detroit.

Background: In this paper, we explore social spaces related to street sex work and illicit drug use in Detroit. We consider these spaces as assemblages (Duff, 2011, 2013; Latour, 2005) that reflect the larger moral geography (Hubbard, 2012) of the city and fulfill specific functions in the daily lives of drug using sex workers.

Methods: We draw on thirty-one in-depth qualitative interviews with former street sex workers who were recruited through a court-based treatment and recovery program, as well as ethnographic field notes from drug treatment and law enforcement settings.

Heroin mismatch in the Motor City: addiction, segregation, and the geography of opportunity.

In this article, the authors used data from economic and ethnographic interviews with heroin users from Detroit, Michigan, as well as other sources, to illustrate the relationship between heroin users' mobility patterns and urban and suburban environments, especially in terms of drug acquisition and the geography of opportunity. The authors found that although geographic location and social networks associated with segregation provided central city residents and African Americans with a strategic advantage over White suburbanites in locating and purchasing heroin easily and efficiently, this same segregation effectively focuses the negative externalities of heroin markets in central city neighborhoods. Finally, the authors consider how the heroin trade reflects and reproduces the segregated post-industrial landscape and discuss directions for future research about the relationship between ethnic and economic ghettos and regional drug markets.

A hell of a life: addiction and marginality in post-industrial Detroit.

Drawing on concepts from Foucault and Agamben, we maintain that the lives of daily heroin users provide a prime illustration of bare life in the zone of indistinction that is contemporary Detroit. First, we consider the case of Detroit as a stigmatized and racially segregated city, with concrete consequences for its residents. We then present evidence from in-depth ethnographic and economic interviews to illustrate the various spaces of confinement-that of addiction, that of economic marginality, and that of gender-occupied by these men and women, as well as the indeterminacy of their daily lives, captured through their descriptions of daily routines and interactions.

Down on main street: drugs and the small-town vortex.

Ethnographic research on social networks-especially that which focuses on rural or small-town drug use-is relatively rare. Drawing on qualitative interviews and focus groups conducted with illicit drug users residing in three counties in west central Ohio, this article examines perceptions of small-town life and the influence of local social networks on drug-using practices. Since chronic drug use is often driven by associations with other users, the combination of small social circles, a limited scope of acquaintances and economic opportunities, inadequate drug treatment, and abundant drug supplies can create a "vortex" effect and magnify drug use in small towns.

Needles in the haystacks: the social context of initiation to heroin injection in rural Ohio.

Although there has been much research on the social context of heroin injection, little has been reported outside of major urban areas. This article examines contextual factors associated with initiation to heroin injection in rural Ohio, based on semistructured qualitative interviews and focus groups involving 25 recent heroin injectors (12 women, 13 men) recruited from three contiguous counties between June 2002 and February 2004. Curiosity about the drug's effects, the growing pressures of drug dependence and economic need, and the influence of intimate and group relations were all identified as factors that offset fears commonly associated with injection.

Adaptability and the integration of computer-based information processing into the dynamics of organizations.

The structure of a system influences its adaptability. An important result of adaptability theory is that subsystem independence increases adaptability [Conrad, M., 1983.

Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.

Within the kidney, angiotensin II type 2 (AT(2)) receptor mediates phospholipase A(2) (PLA(2)) activation, arachidonic acid release, epidermal growth factor (EGF) receptor transactivation, and mitogen-activated protein kinase activation. Arachidonic acid mimics this transactivation by an undetermined mechanism. The role of c-Src in mediating angiotensin II and arachidonic acid signaling was determined by employing immunocomplex kinase assay, Western blotting analysis, and protein immunoblotting on co-precipitated EGF receptor (EGFR) proteins and agarose conjugates of glutathione S-transferase fusion proteins containing the c-Src homology 2 (SH2) and SH3 domains.

Market and efficiency-based strategic responses to environmental changes in the health care industry.

This study examined the linkages between perceived environmental changes in the health care industry, corresponding strategic adaptations, and their impact on select performance measures as reported by managers. Results from a sample of 187 hospitals indicate that efficiency-oriented strategy is chosen more often by organizations that perceive their industry environment to be relatively stable and certain while market-focused strategies are chosen more often by organizations that perceive greater environmental instability and uncertainty.

Digital and biological computing in organizations.

Michael Conrad unveiled many of the fundamental characteristics of biological computing. Underlying the behavioral variability and the adaptability of biological systems are these characteristics, including the ability of biological information processing to exploit quantum features at the atomic level, the powerful 3-D pattern recognition capabilities of macromolecules, the computational efficiency, and the ability to support biological function. Among many other things, Conrad formalized and explicated the underlying principles of biological adaptability, characterized the differences between biological and digital computing in terms of a fundamental tradeoff between adaptability and programmability of information processing, and discussed the challenges of interfacing digital computers and human society.