Examining Knowledge and Attitudes Regarding Social Determinants Among Nursing Students Following Immersive Virtual Reality Simulation: A Descriptive Study.

This quantitative descriptive study explored the impact of virtual reality (VR) simulation on nursing students' understanding of social determinants of health (SDOH). The study assessed students' knowledge and attitudes toward SDOH after participating in VR simulations that mimicked diverse home environments and client scenarios. The intervention was intended to prepare future nurses for practice in diverse community settings and deepen their understanding of community challenges, particularly those impacted by socioeconomic disparities.

Evaluation of a non-nucleoside inhibitor of the RSV RNA-dependent RNA polymerase in translatable animals models.

Respiratory Syncytial Virus (RSV) causes severe respiratory infections and concomitant disease resulting in significant morbidity and mortality in infants, elderly, and immunocompromised adults. Vaccines, monoclonal antibodies, and small-molecule antivirals are now either available or in development to prevent and treat RSV infections. Although rodent and non-rodent preclinical animal models have been used to evaluate these emerging agents, there is still a need to improve our understanding of the pharmacokinetic (PK)-pharmacodynamic (PD) relationships within and between animal models to enable better design of human challenge studies and clinical trials.

Evaluating Large Language Models for the National Premedical Exam in India: Comparative Analysis of GPT-3.5, GPT-4, and Bard.

Background: Large language models (LLMs) have revolutionized natural language processing with their ability to generate human-like text through extensive training on large data sets. These models, including Generative Pre-trained Transformers (GPT)-3.5 (OpenAI), GPT-4 (OpenAI), and Bard (Google LLC), find applications beyond natural language processing, attracting interest from academia and industry.

A Phase-Field Model for In-Space Manufacturing of Binary Alloys.

The integrity of the final printed components is mostly dictated by the adhesion between the particles and phases that form upon solidification, which is a major problem in printing metallic parts using available In-Space Manufacturing (ISM) technologies based on the Fused Deposition Modeling (FDM) methodology. Understanding the melting/solidification process helps increase particle adherence and allows to produce components with greater mechanical integrity. We developed a phase-field model of solidification for binary alloys.

Preventing dog bites with L.O.V.E.

Children can be vulnerable to dog bites when they don't recognize aggressive cues, highlighting the importance of safe child-dog interactions. This article explains how anticipatory guidance with L.O.

Developing Fused Deposition Modeling Additive Manufacturing Processing Strategies for Aluminum Alloy 7075: Sample Preparation and Metallographic Characterization.

Currently, no commercial aluminum 7000 series filaments are available for making aluminum parts using fused deposition modeling (FDM)-based additive manufacturing (AM). The key technical challenge associated with the FDM of aluminum alloy parts is consolidating the loosely packed alloy powders in the brown-body, separated by thin layers of surface oxides and polymer binders, into a dense structure. Classical pressing and sintering-based powder metallurgy (P/M) technologies are employed in this study to assist the development of FDM processing strategies for making strong Al7075 AM parts.

Acute Pancreatitis: Causation, Diagnosis, and Classification Using Computed Tomography.

Acute pancreatitis can cause serious but nonspecific symptoms, and rapid diagnosis often is critical for patient outcomes. There are varying causes of acute pancreatitis making diagnosis difficult. A combination of patient history assessment, laboratory tests, and imaging examinations is indicated to diagnose the disease definitively.

Multisite Study Assessing the Effect of Cognitive Test Anxiety on Academic and Standardized Test Performance.

To evaluate the degree of cognitive test anxiety (CTA) present in student pharmacists at multiple pharmacy programs in the United States and to determine if there are associations between self-reported CTA and relevant academic outcomes. All 2018-2019 advanced pharmacy practice experience (APPE) students from three US Doctor of Pharmacy (PharmD) programs (N=260) were invited to participate in the study. Participants completed a validated 37-question survey that included the Cognitive Test Anxiety Scale-2 (CTAS-2) along with demographics-related questions.

Test-Retest Reliability of Remote ImPACT Administration.

Objective: To evaluate the performance and test-retest reliability obtained when administering a computerized baseline neurocognitive exam to NCAA Division I student-athletes in a controlled laboratory setting versus an uncontrolled remote location.

Method: A sample of 129 (female = 100) Division I student-athletes completed Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) pre-season assessments for two distinct and respective sports seasons in a controlled laboratory environment and an uncontrolled remote environment. Depending on the environment, participants were given verbal (controlled) or written (uncontrolled) guidelines for taking the test.

Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis.

Background: The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an essential cytokine for myotube formation, STAT6 might also be involved in myogenesis as part of IL-4 signaling. This study was conducted to elucidate the role of STAT6 in adult myogenesis in vitro and in vivo.

Assessment of C-arm Confidence Among ASRT Graduate Bridge Program Members.

Purpose: To identify the amount of C-arm preparation or instruction that recent graduates received in their radiography programs before starting clinical rotations and to determine whether completing more rotations increased their confidence in operating C-arm equipment.

Methods: Members of the American Society of Radiologic Technologists' Graduate Bridge program who indicated a primary pathway in radiography received an invitation to complete the C-arm confidence survey and self-report their C-arm experiences during clinical education.

Results: A third of the participants indicated they received preparation or instruction on C-arm equipment before beginning clinical rotations, with the majority of those indicating they had completed a C-arm laboratory.

Stacked LSTM based deep recurrent neural network with kalman smoothing for blood glucose prediction.

Background: Blood glucose (BG) management is crucial for type-1 diabetes patients resulting in the necessity of reliable artificial pancreas or insulin infusion systems. In recent years, deep learning techniques have been utilized for a more accurate BG level prediction system. However, continuous glucose monitoring (CGM) readings are susceptible to sensor errors.

Beliefs related to Pap smear intention among Jamaicans: A qualitative research study.

Globally, most women who are diagnosed with cervical cancer do not obtain regular screening with the Pap smear/test. Women in developing countries have high cervical cancer incidence and mortality. Therefore, a qualitative research study was conducted to determine the referents, and salient and control beliefs related to Pap smear/test intention among Jamaicans.

Pediatric Tracheostomy Wound Healing: A Retrospective Cohort Study.

Objective: To compare wound products by measuring time to granulation tissue and time to complete wound healing for tracheostomy wounds in the pediatric population.

Methods: Investigators identified 134 charts of patients treated January 2013 and June 2017; 93 charts met the inclusion criteria. This study compared the use of a foam dressing (n = 34) to the foam dressing plus a wound filler (n = 59) in patients who developed or were admitted with a wound caused by a tracheostomy device.

Are fishbowl activities effective for teaching pharmacotherapy and developing postformal thought in pharmacy students? A pilot study.

Background And Purpose: Case based learning is a commonly used pedagogy to facilitate active learning and development of problem-solving skills, however its utility may be limited in a large lecture environment. Fishbowl activities have been utilized in higher education to encourage discussion and postformal thinking and may be useful in engaging large class sizes in collective problem-solving activities.

Educational Activity And Setting: The fishbowl activity took place in a second-year six-credit hour infectious disease course delivered in the spring of 2017, consisting 95 students.

Primary care management of obesity: Individualized treatment strategies.

Obesity is a growing epidemic in the United States. This article explores the popular diet trends in the country and analyzes their potential for use among patients with comorbid conditions. The American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for obesity management are used as a framework for comparison of obesity management options.

Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide.

Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy sensor 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibits reproductive neuroendocrine function in short term, e.

A novel method for strict intranasal delivery of non-replicating RSV vaccines in cotton rats and non-human primates.

Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings.

Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo.

One of the major mediators of multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) is the overexpression of ATP-binding cassette subfamily G member 2 (ABCG2). In this study, we conducted in vitro and in vivo experiments to determine whether PD153035, an inhibitor of EGFR, could reverse ABCG2-mediated MDR in human NSCLC and transfected cells overexpressing ABCG2. The efficacy of SN-38, topotecan, and mitoxantrone (MX) were significantly increased by PD153035, PD153035 significantly reversed ABCG2-mediated MDR by attenuating the efflux activity of this transporter.

Rebound Feeding in the Wake of Short-Term Suspension of Food Intake Differs in the Presence of Estrous Cycle Peak versus Nadir Levels of Estradiol.

Background: Short-term interruption of feeding is ordinary in modern life but negatively impacts appetite control and body weight. Estradiol (E) imposes long-term inhibitory tonus on food consumption; however, E influence on energy repletion secondary to food deprivation (FD) is unclear. This study investigated the hypothesis that E signal strength regulates hyperphagic responses to FD of varying duration.

Differential host mortality explains the effect of high temperature on the prevalence of a marine pathogen.

Infectious diseases threaten marine populations, and the extent of their impacts is often assessed by prevalence of infection (the proportion of infected individuals). Changes in prevalence are often attributed to altered rates of transmission, although the rates of birth, recovery, and mortality also determine prevalence. The parasitic dinoflagellate Hematodinium perezi causes a severe, often fatal disease in blue crabs.

Nursing Faculty Attitudes and Practices Related to Online Teaching.

Online education as a teaching methodology is relatively new in higher education in comparison to traditional face-to-face instruction. There is often concern that the quality of online classes is inferior and that academic rigor is compromised when faculty are not engaged with students in a classroom. The purpose of this pilot study was to assess nursing faculty attitudes and practices regarding online teaching.