14 results match your criteria: "The University of Lahore. Pakistan.[Affiliation]"

Objective: The SEC24D (SEC24 Homolog D, COPII Coat Complex Component) gene belongs to the SEC24 subfamily of genes. The protein encoded by this gene, along with its other binding partners, mediates the transport of newly-synthesized proteins from the endoplasmic reticulum to the Golgi apparatus.

Methods: A pan-cancer analysis of this gene, as well as its diagnostic and prognostic implications, are lacking in the medical literature.

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Naphthoquinones and derivatives as potential anticancer agents: An updated review.

Chem Biol Interact

December 2022

Department of Crop Science, College of Sanghuh Life Sciences, Konkuk University, Seoul 05029, South Korea; Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India. Electronic address:

One of the leading global causes of death is cancer; even though several treatment methods have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones are a type of quinone that is found in nature and has vital biological roles. These chemicals have anticancer (antineoplastic), analgesic, anti-inflammatory, antimalarial, antifungal, antiviral, antitrypanosomal, antischistosomal, leishmanicidal, and anti-ulcerative effects.

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The liver and kidneys are the vital organs of the body and perform important life-sustaining functions in the body. Synthetic drugs used in the treatment of liver and kidney diseases are sometimes inadequate and can lead to serious side effects. Medicinal herbs and plants were used to combat diseases for a long time and combination therapy is preferred over single plant therapy.

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A smart diagnostic tool based on deep kernel learning for on-site determination of phosphate, calcium, and magnesium concentration in a hydroponic system.

RSC Adv

March 2021

Key Laboratory of Agricultural Informatization Standardization, Ministry of Agriculture and Rural Affairs Beijing 100083 China.

Calcium, phosphate, and magnesium are essential nutrients for plant growth. The determination of these nutrients is an important task for monitoring them in a closed hydroponic system where the nutrient elements need to be individually quantified based on ion-selective electrode (ISE) sensing. The accuracy issue of calcium ISEs due to interference, drift, and ionic strength, and the unavailability of phosphate and magnesium ISEs makes the development of these ion detecting tools hard to set up in a hydroponic system.

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Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project.

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Objective: To compare the outcomes of intraoral versus extraoral approach in the treatment of mandibular angle fracture.

Methods: The randomised controlled trail was conducted at the Department of Maxillofacial Surgery, Mayo Hospital, Lahore Pakistan, from September 2016 to March 2017, and comprised patients of mandibular angle fracture who were divided into two equal extraoral group A and intraoral group B. .

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Objective: To compare the mean decrease in mouth opening by autologous blood injection in superior joint space with and without pericapsular tissue in the treatment of chronic recurrent temporomandibular joint dislocation.

Methods: The prospective study was conducted at the department of Oral and Maxillofacial Surgery, King Edward Medical University, Mayo Hospital, Lahore, Pakistan, from July, 2015, to January, 2016, and comprised patients, divided into two equal groups, having chronic temporomandibular joint dislocation. Group A patients were injected with autologous blood 2ml by 18-gauge single needle technique in superior joint space, while in group B patients, the needle was moved outward for 1cm and an additional 1ml of blood was injected in the pericapsular tissue under local anaesthesia in single setting after scrubbing local area with antiseptic solution.

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LMI-DForest: A deep forest model towards the prediction of lncRNA-miRNA interactions.

Comput Biol Chem

December 2020

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Peng Cheng Laboratory, Shenzhen, Guangdong, China. Electronic address:

The interactions between miRNAs and long non-coding RNAs (lncRNAs) are subject to intensive recent studies due to its critical role in gene regulations. Computational prediction of lncRNA-miRNA interactions has become a popular alternative strategy to the experimental methods for identification of underlying interactions. It is desirable to develop the machine learning-based models for prediction of lncRNA-miRNA based on the experimentally validated interactions between lncRNAs and miRNAs.

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Background: The spices based dietary interventions are in lime light among the scientific community owing to their promising therapeutic perspective. The bioactive components in spices can be used to exert various health promoting functions in human body such as prompting weight loss, inhibit diet-induced obesity, hypercholesterolemia, hyperglycemia, allergies and various other maladies. In current study extraction and in vitro characterization of coriander seed (CS), black cumin seed (BCS) and fenugreek seed (FS) polyphenols was conducted for further development of dietary intervention against lipid and glycemia related abnormalities in experimental Sprague Dowley rats fed with control and different spice powder supplemented diets.

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Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2).

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Honokiol: An anticancer lignan.

Biomed Pharmacother

November 2018

Department of Chemistry, Faculty of Science, Northern Borders University, Saudi Arabia.

Background: Honokiol ((3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol), a lignan, is a promising antitumor compound, having exerted activity against a number of human cancer cell lines. Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. It interferes with signaling pathways components in order to elicit the anticancer effect.

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Diet plays a key role to maintaining healthy life. Many natural products present in our diet, such as flavonoids, can prevent the progression of cancer. Quercetin, a distinctive bioactive flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its numerous health-promoting effects.

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Background: Recently oxidative stress induced maladies have amplified owing to sedentary lifestyle and monotonous diet. Introduction of plant based biomolecules may be a suitable strategy to cope with the lipid peroxidation. In this context, black tea polyphenols (theaflavin & thearubigins) are in fame among the scientific community as cost effective therapeutic agents owing to their safety, economics, structural diversity and ability to modulate various lipid peroxidation responses by halting the expression of different metabolic targets.

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