1,960 results match your criteria: "The University of Lahore.[Affiliation]"

Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.

Curr Med Chem

September 2024

Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil and Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil.

Background: Geranyl acetate, a compound found in plant oils, has been studied for its potential effects on renal and cardiovascular ailments.

Objective: This study aimed to investigate the diuretic and anti-hyperuricemic properties of geranyl acetate in male Wistar rats using a hyperuricemia-induced rat model.

Methods: Molecular docking studies were conducted to assess geranyl acetate's interactions with various targets.

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Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus.

Emerg Microbes Infect

December 2024

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health; Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People's Republic of China.

Article Synopsis
  • - In 2022, the monkeypox virus spread worldwide, highlighting the urgent need for effective antiviral treatments, particularly due to the limited options available.
  • - Researchers developed and tested multiple monoclonal antibodies (mAbs) against monkeypox, identifying several with strong antiviral effects, especially a duo called M1H11 and M3B2, which worked better together.
  • - A bispecific antibody, Bis-M1M3, showed protective effects in mice and had a long duration in the bloodstream of rhesus macaques, paving the way for future antiviral drug development against monkeypox and related viruses.
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Hyperlipidemia significantly contributes to the risk of developing cardiovascular diseases. However, about half of the patients do not adhere to their antihyperlipidemic medications, leading to healthcare costs and premature mortality. This study's objective was to determine the prevalence and associated factors of non-adherence to antihyperlipidemic medications.

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The discordance between phenotypic and molecular methods of rifampicin (RIF) drug susceptibility testing (DST) in poses a significant challenge, potentially resulting in misdiagnosis and inappropriate treatment. A comparison of RIF phenotypic and molecular methods for DST, including whole genome sequencing (WGS), may provide a better understanding of resistance mechanisms. This study aims to compare RIF DST in using two phenotypic and molecular methods including the GeneXpert RIF Assay (GX) and WGS for better understanding.

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Background: Dental students face the rigorous demands of coursework, which can lead to feelings of inadequacy and stress. These pressures can negatively influence self-efficacy and cause neglect in practicing healthy behaviors that encompass oral health. Identifying the associations of these variables with oral hygiene practices can help in the formulation of interventions tailored toward supporting young students.

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In the context of graph theory and chemical graph theory, this research conducts a detailed mathematical investigation of reverse topological indices as they relate to iron telluride networks, clarifying their complex interactions. Graph theory is a branch of abstract mathematics that carefully studies the connections and structural features of graphs made up of edges and vertices. These theoretical ideas are expanded upon in chemical graph theory, which models molecular architectures with atoms acting as vertices and chemical bonds as edges.

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Objective: Balloon catheters have shown promising results in the induction of labor (IOL); however, evidence regarding the optimal time of balloon catheter placement is still lacking. Thus, this study aims to evaluate the efficacy and safety of 6-hour placement compared to 12 hours.

Data Source: We conducted a comprehensive search through a search strategy across "Embase, SCOPUS, PubMed (via MEDLINE), and Cochrane Central Register of Controlled Trials (CENTRAL)" from inception until April 20, 2024.

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Article Synopsis
  • - The study compares the yield and properties of peppermint essential oil (EO) extracted using hydro-distillation (HD) and supercritical fluid extraction (SCFE) methods, finding a higher yield for HD (0.20%) compared to SCFE (0.13%).
  • - Chemical analysis showed that menthol was the main component in both extraction methods, but SCFE-EO exhibited stronger antioxidant and antimicrobial activities than HD-EO, specifically with significant free radical inhibition and larger inhibition zones against certain bacteria.
  • - Overall, SCFE is suggested to be a more effective method for producing high-quality peppermint EO, making it a promising candidate for developing nutra-pharmaceutical products.
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Minimally invasive surgery (MIS) provides superior results in the surgical treatment of inflammatory bowel disease (IBD). There exist various minimally invasive procedures, each possessing its own set of benefits and drawbacks. This literature review outlines these methodologies and underscores their importance in enhancing the outcomes of patients with IBD.

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This work examines the (2+1)-dimensional Boiti-Leon-Pempinelli model, which finds its use in hydrodynamics. This model explains how water waves vary over time in hydrodynamics. We provide new explicit solutions to the generalized (2+1)-dimensional Boiti-Leon-Pempinelli equation by applying the Sardar sub-equation technique.

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Article Synopsis
  • - Rheumatoid arthritis (RA) causes joint inflammation and pain, mainly affecting the metacarpophalangeal and proximal interphalangeal joints, with treatment typically combining biological medications and steroids.
  • - An experimental study used gingerol-loaded nanoparticles to improve RA treatment in rats, assessing the effects through various inflammatory markers and gene expression after 21 days of oral administration.
  • - Results showed significant changes in inflammatory gene levels between the treated and control groups, indicating that the gingerol nanoparticles had enhanced therapeutic effects for RA.
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: Pre-eclampsia (PE) is a pregnancy-specific condition characterized by significant health risks for pregnant women worldwide due to its status as a multi-organ disorder. High blood pressure (hypertension) with or without proteinuria is usually considered an initial clinical sign of PE. The pathogenesis of pre-eclampsia is highly complex and likely involves multiple factors, including poorly developed uterine spiral arterioles, immunological issues, placental ischemia or infarction, and genetic abnormalities.

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Article Synopsis
  • * The study investigated the effects of biochar application on wheat varieties (FSD08 and PUNJAB-11) under salinity stress, using different sodium chloride levels and biochar concentrations.
  • * Results showed that biochar significantly mitigated the negative impacts of salt on growth and yield, and enhanced the plant's self-defense mechanisms, suggesting it as a beneficial amendment for sustainable crop production in saline conditions.
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This study endeavors to examine the dynamics of the generalized Kadomtsev-Petviashvili (gKP) equation in (n + 1) dimensions. Based on the comprehensive three-wave methodology and the Hirota's bilinear technique, the gKP equation is meticulously examined. By means of symbolic computation, a number of three-wave solutions are derived.

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Article Synopsis
  • Widespread pesticide use poses serious health risks to living organisms, prompting the need for better monitoring methods for pesticide residues.
  • This study develops a new sensing material, KL@Ni@g-CN, made from graphitic carbon nitride, Kraft lignin, and nickel, which is used to detect pesticide residues.
  • The sensor effectively detects cypermethrin (CYP) residues in drinking water at extremely low levels (0.026 μg mL), significantly below the maximum safety limits, suggesting it could be a better alternative to traditional detection methods.
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This article demonstrates a mathematical model and theoretical analysis of the Micropolar fluid in the reverse roll coating process. It is important because micropolar fluids account for the microstructure and microrotation of particles within the fluid. These characteristics are significant for accurately describing the behavior of complex fluids such as polymer solutions, biological fluids, and colloidal suspensions.

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This study investigated the adsorption of Oxytetracycline (OTC) from pharmaceutical wastewater using a kappa carrageenan based hydrogel (KPB). The aim of the present study was to explore the potential of KPB for long-term pharmaceutical wastewater treatment. A sustainable adsorbent was developed to address oxytetracycline (OTC) contamination.

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The Changes of Microbial Diversity and Isolation of Microorganism in Soil for Alleviating the Production Decreasing After Continuous Cultivation of Ganoderma lucidum.

Curr Microbiol

August 2024

National Engineering Research Centre of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilisation, Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agriculture Sciences, 1000 Jinqi Road, Shanghai, 201403, China.

Ganoderma lucidum is a medicinal mushroom usually cultivated in logs and covered with soil. Its production decreases after continuous cultivation. Changes of microbial diversity in soil are suggested to be one of the reasons.

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Improved efficacy of linear glutathione-peptide chaperon complexes on melanogenesis inhibition and transdermal delivery.

Bioorg Chem

November 2024

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250024, China; Shandong Provincial Key Laboratory of Fine Chemicals, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China; Cosmetic Institute of North Beauty Value, Jinan 250307, China. Electronic address:

Article Synopsis
  • Glutathione (GSH) has potential in cosmetics for reducing melanin production, but its effectiveness is limited by poor skin absorption.
  • Researchers introduced TD1, a peptide that enhances GSH delivery to the skin's basal layer, and tested two variations: linear and branched structures.
  • The study found that the linear structure (TD1-linker-GSH) significantly inhibited melanin production and showed effective penetration into the skin, indicating a promising method for skin pigmentation control.
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The presence of chromium [Cr(VI)] and lead [Pb(II)] ions in the water bodies have adverse effects on humans and aquatic life. Graphene oxide-based magnetic nanocomposites synthesized in the presence of chitosan (mGO/CS) or polyaniline (mGO/PA) as potential adsorbents for the removal of Cr(VI) and Pb(II) ions. The FTIR (Fourier transform infrared spectroscopy), EDX (Energy dispersive X-ray), XRD (X-ray diffraction) and SEM (Scanning electron microscopy) were employed to investigate the chemical composition, structural, elemental analysis, crystalline size and morphology of the nanocomposites.

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The focus of present study is to incorporate the variable viscosity and temperature slip impact on heating rate and induced magnetic gradient along the moving non-conducting wedge under magnetic field. In industrial and engineering procedures, the impact of induced magnetization improves the efficiency of thermal systems to main the heating rates. The similarity transformations and stream functions are applied to reduce the governing equations into ordinary form.

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Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery.

Front Cell Infect Microbiol

August 2024

Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Article Synopsis
  • Extracellular vesicles (EVs) play a crucial role in communication and disease processes for parasitic helminths, which are significant contributors to global health issues.
  • Recent studies show that EVs, which include microvesicles and exosomes, are involved in the lifecycle, immune evasion, and disease progression of helminths by transferring various biological materials between cells.
  • These findings suggest that EVs serve as promising tools for diagnosing and treating parasitic infections, along with identifying potential targets for new therapies and vaccines.
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In this study, we conduct a comprehensive physical analysis of topological indices for the Iron Disulfide (FeS ) network using a curve-fitting model. Iron Disulfide is a cubic compound. In metamorphic rock, sedimentary rock, and quartz veins, it is typically found in combination with other sulfides or oxides.

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