A Glimpse of Noncoding RNAs: Secondary Structure, Emerging Trends, and Potential Applications in Human Diseases.

An appealing strategy for the treatment of several diseases is the therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Many antisense oligonucleotides and small interfering RNAs have been tested in clinical studies over the past 10 years, and several of these have received FDA approval. However, trial results have thus far been mixed, with some studies reporting strong effects and others showing low effectiveness or side effects, including toxicity.

Modulation of miR-205 expression using a phyto-nano hybrid as a potential therapeutic agent against breast cancer.

Breast cancer is the fifth major cause of fatalities associated with cancer worldwide and in Pakistan, 34 066 female breast cancer cases were recorded in 2018. This study was designed to understand extracts of () and to evaluate the epigenetic modulation of microRNA expression for breast cancer therapy using a selected phyto-nanohybrid treatment. The phytochemical screening revealed the presence of potential phytochemicals and antioxidant scavenging activity in the extracts with a DPPH (2-diphenyl-1-picryl-hydroxyl) assay giving an IC value of 20.

Clinical pharmacist-led antifungal drug utilization reviews in cancer care hospital: a prospective audit and feedback.

Background And Objective: The global rise in systemic fungal infections and increased antifungal use underscores the need for pharmacist-led antifungal stewardship in oncology but data on such interventions are scarce. This study aimed to evaluate the clinical pharmacist-led antifungal drug utilization reviews for optimizing antifungal therapy in a specialized cancer care hospital.

Patients And Method: This pharmacist-led prospective audit and feedback study evaluated 350 admitted patients with cancer who were prescribed systemic antifungals.

Thapsigargin and its prodrug derivatives: exploring novel approaches for targeted cancer therapy through calcium signaling disruption.

Thapsigargin, a sesquiterpene lactone derived from Thapsia garganica L., has demonstrated mixed potential as an anticancer agent due to its potent ability to disrupt calcium signaling and induce apoptosis. This review evaluates the chemopreventive and chemotherapeutic potential of thapsigargin, focusing on its molecular mechanisms and toxicity.

Cross-sectional assessment of perception and attitude of pharmacy students towards pharmaceutical promotion: a study from developing country, Pakistan.

Background: The pharmaceutical promotion is "all informational and persuasive activities by manufacturers and distributors, the effect of which is to induce the prescription, supply, purchase and/or use of medicinal drugs. These promotional activities affect the dispensing behavior of physicians and pharmacists and influence begins from educational institutes.

Objective: Our study's main aim was to evaluate opinion and attitude of pharmacy students towards pharmaceutical promotion.

Anticancer potential of Diospyrin and its analogues: An updated review.

Cancer, characterized as one of the leading causes of death owing to its heterogeneity and complexity, hence poses a significant challenge to health care system across the globe. Current therapies for cancer curtailment are considered to have associated side effects, therefore discovery of novel alternative approaches is need of the time. In this context, natural products have attained an essential spot in the scientific community for the development of novel cancer treatments.

Rotor angle stability of a microgrid generator through polynomial approximation based on RFID data collection and deep learning.

The article proposes a novel approach to assess rotor angle stability in microgrids by enhancing the Modified Galerkin Method (MGM), which is based on the Polynomial Approximation, using real-time RFID data acquisition. Due to their reliance on assumptions, traditional rotor angle stability methodologies frequently fail in online transient stability testing. MGM successfully captures the dynamic behavior of microgrids by approximating state variables using a sequence of polynomials and coefficients.

Comp arison of c yclop legic refraction in ch i ldren w i th different iris c olou r cat eg ories: A cross- sec tio na l survey.

Objective: To compare the cycloplegic refraction in children with different iris colour categories and age groups.

Methods: The cross -sectional study was conducted from December 2 022 to June 2023 at the Eye Clinic of Sehat Medical Complex, Hanjarwal, Lahore, and Khizar Eye Centre, Lahore, Pakistan, and comprised hyperopic children aged 5-12 years of either gender. Data regarding age, gender, iris colour, auto -refraction and retinoscopy before and after cycloplegic refraction was collected using a structured proforma.

Stigma, caregiver burden, and expressed emotions: The moderating role of self-compassion in caregivers of substance use disorder.

Objectives: To investigate the moderating effect of self-compassion on the relationship involving stigma, caregiver burden and expressed emotions among caregivers of males diagnosed with substance use disorder.

Methods: The correlational, quantitative study was conducted from June 1 to September 30, 2021, at the Department of Psychology, University of Central Punjab, Lahore, Pakistan, and comprised caregivers aged 40-55 years living with individuals with substance use disorder and actively performing caregiving duties for at least six months. Data was collected using validated tools.

Effects of Kabat rehabilitation versus mime therapy on facial disability and synkinesis in patients of Bell's palsy.

Objective: To compare the effects of Kabat rehabilitation and Mime therapy on facial disability and synkinesis in patients with Bell's palsy.

Methods: The single-blind, randomised clinical trial was conducted at the Physiotherapy Department of the University of Lahore Teaching Hospital, Lahore, Pakistan, from May to October 2023, and comprised adults of either gender aged 25-50 years having sub-acute or chronic unilateral Bell's palsy of non-congenital origin. The patients were randomised into Kabat rehabilitation group A and mime therapy group B.

ChessCrypt: enhancing wireless communication security in smart cities through dynamically generated S-Box with chess-based nonlinearity.

In the contemporary landscape of smart cities, ensuring the security and confidentiality of transmitted data has become paramount. The proliferation of Internet of Things (IoT) devices, mobile communication platforms, and wireless sensor networks has magnified the need for robust cryptographic solutions to safeguard sensitive information from malicious adversaries. In response to these challenges, we introduce ChessCrypt-a novel approach to enhancing wireless communication security through the development of a new S-Box algorithm inspired by the nonlinear movement patterns of chess pieces.

Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.

Objectives: Diabetes mellitus is a metabolic condition with hyperglycemia. Literature has shown a correlation between poor sleep quality and duration with an increased incidence of insomnia in diabetic individuals. The goal of this study was to determine the magnesium and potassium supplementation effect among diabetic individuals with insomnia.

NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression.

Treatment of inflammatory bowel disease (IBD), a common chronic intestinal disease, by exopolysaccharides (EPSs) produced by lactic acid bacteria has raised increasing concerns. Here, the EPS produced by NMGL2 was evaluated for its ameliorating effect on dextran sodium sulfate (DSS)-induced IBD in mice. Administration of the EPS was shown to decrease the body weight loss and the values of disease activity index (DAI) and alleviate the colon damage as evidenced by an improvement in colonic length shortening, a reduction in colonic coefficient, and a reduction in colonic mucosal architecture and inflammatory infiltration.

Variable viscosity and activation energy aspects in convection heat transfer over gravity driven solar collector plate for thermal energy storage.

Variable viscosity, activation energy and microgravity effects on Darcy nanofluid for the thermal performance improvement in thermal energy storage systems through stretching flat plate solar collector is the focus of this research. Thermal energy storage (TES) can be improved though solar collectors, phase change materials and photovoltaic cells using nanofluid in the base liquid. To increase the reaction rate in nanoparticles, the activation energy and solar radiations are used for the efficiency of TES.

GABA (γ-aminobutyric acid) enrichment and detection methods in cereals: Unlocking sustainable health benefits.

Gamma-aminobutyric acid (GABA), a non-protein amino acid primarily biosynthesized in cereals, is vital to the human neurological system. As the primary neurotransmitter, it promotes relaxation, inhibits depression and sleeplessness, and regulates synaptic transmission and neuronal development. GABA also protects the liver, kidneys, and intestines, reduces blood pressure, and fights cancer and inflammation.

Potential Target Metabolites From Gut Microbiota Against Hepatocellular Carcinoma: A Network Pharmacology and Molecular Docking Study.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, posing significant challenges and economic burdens on healthcare systems. Gut microbiota metabolites have shown promise in cancer treatment, but the specific active metabolites and their key targets remain unclear. This study employed a network pharmacology-based approach to identify potent metabolites of gut microbiota and their key targets.

Impact on Carbohydrate Metabolism and Oxidative Stress in a Type 2 Diabetic Rat Model.

This study was conducted to assess the possible antidiabetic potential of by employing as well as assessments. The dried plant material was extracted in methanol, ethanol, and water. The in vitro results showed that the ethanolic extract (EthCb) was found to have higher antioxidant and antidiabetic potential as compared with the aqueous (AqCb) and methanolic extracts (MthCb) so it was further evaluated in the in vivo trial using a diabetic rat model.

Advanced nanomaterials and metal-organic frameworks for catalytic bio-diesel production from microalgal lipids - A review.

Increasing energy demands require exploring renewable, eco-friendly (green), and cost-effective energy resources. Among various sources of biodiesel, microalgal lipids are an excellent resource, owing to their high abundance in microalgal biomass. Transesterification catalyzed by advanced materials, especially nanomaterials and metal-organic frameworks (MOFs), is a revolutionary process for overcoming the energy crisis.

Performance enhancement in blockchain based IoT data sharing using lightweight consensus algorithm.

The proliferation of Internet of Things (IoT) devices generates vast amounts of data, traditionally stored, processed, and analyzed using centralized systems, making them susceptible to attacks. Blockchain offers a solution by storing and securing IoT data in a distributed manner. However, the low performance and poor scalability of blockchain technology pose significant challenges for its application in IoT networks.

Analyzing boron oxide networks through Shannon entropy and Pearson correlation coefficient.

In the current age of chemical science, chemical graph theory has significantly advanced our understanding of the characteristics of chemical compounds. To simulate the mathematical, chemical, and physical aspects of networks, a topological index, a numerical measure obtained from the graph of a chemical network, employed. Recent work has explored the topological properties of boron oxide using chemical graph theory.