39 results match your criteria: "The University of Hongkong-Shenzhen Hospital[Affiliation]"
Gastroenterol Nurs
October 2024
Qiaomei Liu, MSN, is Registered Nurse, Institute of Nursing Research, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, China.
This study investigates the role of self-perceived burden as a mediating factor in the association between perceived partner responsiveness and fertility intentions in women of reproductive age diagnosed with inflammatory bowel disease. A sample of 366 female inflammatory bowel disease patients from Changsha, China, was recruited using convenience sampling. Participants completed assessments, including the Impact of Perceived Partner Responsiveness Scale, Self-Perceived Burden Scale, Fertility Intentions Questionnaire, and a demographic questionnaire.
View Article and Find Full Text PDFJ Orthop Surg Res
September 2024
Department of Orthopedics, The University of Hongkong-Shenzhen Hospital, Shenzhen, 518053, Guangdong, PR China.
Cell Commun Signal
August 2024
Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in South China, Southeast Asia and North Africa. The intervention of tumor-associated macrophages (Mφs) (TAMs)-mediated immunosuppression is a potential therapeutic strategy against tumor metastasis, but the exact mechanisms of TAM-mediated immunosuppression in nasopharyngeal carcinoma are unclear. Furthermore, how TAM affects the occurrence and development of nasopharyngeal carcinoma through metabolism is rarely involved.
View Article and Find Full Text PDFFront Nutr
August 2024
Department of Nephrology, The University of HongKong-ShenZhen Hospital, ShenZhen, Guangdong, China.
Background And Objective: Depression is a widespread mental health condition that can impact both mental and physical well-being. Prior research has shown that high levels of copper in the blood and low levels of folate are linked to depression. This study aimed to explore whether serum folate levels, independently or in combination with serum copper levels, associated with the risk of depression.
View Article and Find Full Text PDFFront Immunol
July 2024
Department of Urology, Lianshui People's Hospital of Kangda College Affiliated to Nanjing Medical University, Huaian, China.
Background: Anoikis is a form of programmed cell death essential for preventing cancer metastasis. In some solid cancer, anoikis resistance can facilitate tumor progression. However, this phenomenon is underexplored in clear-cell renal cell carcinoma (ccRCC).
View Article and Find Full Text PDFHeliyon
June 2024
Urology Surgery, Shenzhen smaii medical center, Shenzhen City, 518000, China.
This study aimed to analyze the factors associated with intraoperative hypothermia and postoperative shivering rates in patients undergoing complex percutaneous nephrolithotomy (PCNL) and investigate the effects of combined insulation nursing intervention. A total of 168 patients were included, with 103 patients in the control (Ctrl) group receiving routine care and 65 patients in the nursing (Nur) group receiving combined insulation nursing intervention measures. General information, surgical data, temperature, intraoperative hypothermia incidence, postoperative shivering, and complication rates were statistically analyzed between the two groups.
View Article and Find Full Text PDFJ Nanobiotechnology
June 2024
Division of Gastroenterology and Hepatology, The University of Hongkong-Shenzhen Hospital, Shenzhen, China.
Background: Cancer stem cells (CSCs) play a vital role in the occurrence, maintenance, and recurrence of solid tumors. Although, miR-145-5p can inhibit CSCs survival, poor understanding of the underlying mechanisms hamperes further therapeutic optimization for patients. Lentivirus with remarkable transduction efficiency is the most commonly used RNA carrier in research, but has shown limited tumor-targeting capability.
View Article and Find Full Text PDFDiscov Oncol
April 2024
Department of Andrology, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, China.
Background: The prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function of senescence-related genes in tumor development is recognized, their prognostic significance in BLCA has not been thoroughly explored.
Methods: BLCA transcriptome datasets were sourced from the TCGA and GEO repositories.
Am J Cancer Res
March 2024
Division of Urology, Department of Surgery, The University of Hongkong-Shenzhen Hospital Shenzhen 518000, Guangdong, China.
Sci Rep
April 2024
Department of Interventional Radiology, The University of HongKong-Shenzhen Hospital, Shenzhen, 518053, China.
Eur J Nutr
August 2024
Department of Cardiology, The Second Affiliated Hospital, Jiangxi medical College, Nanchang University, Nanchang, China.
Background: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore the efficacy of eight different FA dosages on tHcy lowering in the overall sample and by MTHFR C677T genotypes.
Methods: This multicentered, randomized, double-blind, controlled clinical trial included 2697 eligible hypertensive adults with elevated tHcy (≥ 10 mmol/L) and without history of stroke and cardiovascular disease.
Front Pharmacol
February 2024
The University of Hongkong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Statin is well-established as a classical lipid-lowering drug, and its cost has reduced considerably in the past years. Inclisiran is a new and effective lipid-lowering drug given as a subcutaneous injection at 6-month intervals. This study aims to evaluate the cost-effectiveness of the combination use of inclisiran and statin versus statin alone for dyslipidemia in the mainland China population.
View Article and Find Full Text PDFSci Rep
February 2024
Department of Interventional Radiology, The University of HongKong-Shenzhen Hospital, Shenzhen, 518053, China.
Breast cancer is the most common diagnosed cancer, the HER2-positive subtype account for 15% of all breast cancer. HER2-targeted therapy is the mainstay treatment for HER2-positive breast cancer. Cuproptosis is a novel form of programmed cell death, and is caused by mitochondrial lipoylation and destabilization of iron-sulfur proteins triggered by copper, which was considered as a key player in various biological processes.
View Article and Find Full Text PDFJ Cosmet Dermatol
March 2024
Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Background: Wrinkle formation is the most visible characteristic of facial aging. Radiofrequency (RF) technology is currently utilized to reduce facial wrinkles and contribute to skin rejuvenation.
Objective: To analyze the efficacy and safety of a noninvasive, home-based RF device applied for facial rejuvenation in Chinese people.
Clin Exp Dermatol
December 2023
Departments of Dermatology.
J Cancer Res Ther
August 2023
Department of Thoracic Surgery, Jiangxi Cancer Hospital, Nanchang, Jiangxi; School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Background: Compared with other lung squamous cell carcinomas (LUSC), pulmonary lymphoepithelioma-like carcinoma (pLELC) is closely associated with Epstein-Barr virus (EBV) infections with a unique molecular profile and immune microenvironment. This study was thus established to compare the treatment response and effectiveness of immunotherapy between pLELC and LUSC.
Material And Methods: We enrolled 31 patients with pLELC and 116 with LUSC receiving first-line immunotherapy at three centers in China and compared the treatment response and effectiveness of immunotherapy.
Front Mol Biosci
June 2023
NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, China.
Endometrial cancer (UCEC) is a commonly occurring tumor in females, and polycystic ovary syndrome (PCOS) is closely related to UCEC, but the molecular mechanisms remain unclear. This article aims to explore potential molecular mechanisms in UCEC and PCOS, as well as identify prognostic genes for UCEC. Bioinformatics methods were employed to screen for DEGs in UCEC and PCOS.
View Article and Find Full Text PDFGlia
September 2023
Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Synucleinopathies refer to a range of neurodegenerative diseases caused by abnormal α-synuclein (α-Syn) deposition, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Their pathogenesis is strongly linked to microglial dysfunction and neuroinflammation, which involves the leucine-rich-repeat kinase 2 (LRRK2)-regulated nuclear factor of activated T-cells (NFAT). Of the NFAT family, NFATc1 has been found to be increasingly translocated into the nucleus in α-syn stimulation.
View Article and Find Full Text PDFCNS Neurosci Ther
July 2023
School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
Introduction And Aims: Alzheimer's disease (AD) is characterized by the abnormal accumulation of hyperphosphorylated tau proteins and amyloid-beta (Aβ) peptides. Recent studies have shown that many microRNAs (miRNAs) are dysregulated in AD, and modulation of these miRNAs can influence the development of tau and Aβ pathology. The brain-specific miRNA miR-128, encoded by MIR128-1 and MIR128-2, is important for brain development and dysregulated in AD.
View Article and Find Full Text PDFInt J Mol Sci
November 2022
Precision Medicine and Healthcare Research Center, Center for Biotechnology and Biomedicine, Shenzhen Key Laboratory of Gene and Antibody Therapy, State Key Laboratory of Chemical Oncogenomics, State Key Laboratory of Health Sciences and Technology, Tsinghua-Berkeley Shenzhen Institute (TBSI), Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Hepatocellular carcinoma (HCC) is a major subtype of primary liver cancer with a high mortality rate. Pyroptosis and autophagy are crucial processes in the pathophysiology of HCC. Searching for efficient drugs targeting pyroptosis and autophagy with lower toxicity is useful for HCC treatment.
View Article and Find Full Text PDFJ Oncol
September 2022
Department of Urology, The University of Hongkong-Shenzhen Hospital, Shenzhen, China.
Background: We aimed to study the relationship between transcription factor 19 (TCF19) and cancer immunotherapy in the 33 types of human cancers.
Methods: The Cancer Genome Atlas database was analyzed to obtain the gene expression data and clinical characteristics for the cases of 33 types of cancers. GSE67501, GSE78220, and IMvigor 210 were included in the immunotherapy cohorts.
Front Oncol
June 2022
Department of Urology, Zhuzhou Central Hospital, Zhuzhou, China.
Objective: Many studies have drawn their attention to the immunotherapy of bladder urothelial carcinoma in terms of immunologic mechanisms of human body. These include immunogenicity of the tumor cells and involvement of long non-coding RNA (lncRNA). We constructed a necroptosis-related long noncoding RNA (nrlncRNA) risk factor model to predict BLCA outcomes and calculate correlations with chemosensitivity and immune infiltration.
View Article and Find Full Text PDFBMC Cancer
June 2022
Department of Urology, Zhuzhou Central Hospital, Zhuzhou, 412007, China.
Background: Ferroptosis is an iron-dependent programmed cell death modality that may have a tumor-suppressive function. Therefore, regulating ferroptosis in tumor cells could serve as a novel therapeutic approach. This article focuses on ferroptosis-associated long non-coding RNAs (lncRNAs) and their potential application as a prognostic predictor for bladder cancer (BCa).
View Article and Find Full Text PDFSci Rep
April 2022
Department of Urology, Zhuzhou Central Hospital, Zhuzhou, 412007, China.
Medicine (Baltimore)
March 2022
Tianjin Medical Laboratory, BGI-Tianjin, BGI-Shenzhen, Tianjin, China.
To evaluate the performance of polymerase chain reaction (PCR)-free whole genome sequencing (WGS) for clinical diagnosis, and thereby revealing how experimental parameters affect variant detection.Five NA12878 samples were sequenced using MGISEQ-2000. NA12878 samples underwent WGS with differing deoxyribonucleic acid (DNA) input and library preparation protocol (PCR-based vs PCR-free protocols for library preparation).
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