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Objective: To understand how the concept of Health Information Exchange (HIE) has evolved over time.

Methods: Supplementary analysis of data from a systematic scoping review of definitions of HIE from 1900 to 2014, involving temporal analysis of underpinning themes.

Results: The search identified 268 unique definitions of HIE dating from 1957 onwards; 103 in scientific databases and 165 in Google.

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