Do they really support "your freedom of choice"? FoPNL and the food industry in Brazil.

Introduction: In 2020, Brazil approved the introduction of a new front-of-package nutrition labeling (FoPNL) in the format of a magnifying glass (MG) after years of discussion. There is currently a lack of understanding of the role of the food industry in that process. This study aimed to describe the corporate political activity (CPA) of the food industry and conflicts of interest situations, as they happened during the development and approval of a new FoPNL system in Brazil.

Performance of galactomannan testing from endotracheal aspirate to guide bronchoalveolar lavage in the diagnosis of invasive aspergillosis.

Purpose: Invasive aspergillosis is a major threat to immunocompromised individuals. Galactomannan (GM) is used as a biomarker for invasive aspergillosis. Investigations recommended in current guidelines include GM testing of bronchoalveolar lavage (BAL) fluids.

Generating water/MeOH-soluble and luminescent polymers by grafting 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) ligands onto a poly(ethylene--maleic anhydride) polymer and cross-linking with terbium(III).

The synthesis of two new polymers made from P(E-alt-MA) (poly(ethylene--maleic anhydride) and possessing 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) ligand side chains in 3 and 6 mol%, respectively (P1 and P2, respectively) is described. These polymers were shown to be soluble in MeOH solution and, in the case of P1, also in water, while P2 needed prolonged heating to enable water dissolution. Btp ligands are known for coordinating both d- and f-metal ions and so, herein, we demonstrate by using both UV-Vis absorption, fluorescence emission, as well as time-gated phosphorescence spectroscopies, that both P1 and P2 can bind to Tb(III) ions to give rise to luminescent polymers.

Adverse drug reactions in an ageing PopulaTion (ADAPT) study: Prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients.

Older people experience greater morbidity with a corresponding increase in medication use resulting in a potentially higher risk of adverse drug reactions (ADRs). The aim of this study was to; 1) determine the prevalence and characteristics of ADR-related hospital admissions among older patients (≥65 years) in Ireland; and 2) identify the risk factors associated with ADR-related hospital admissions. A cross-sectional study of ADR prevalence in patients aged ≥65 years admitted acutely to hospital in Ireland over a 8 month period (November 2016- June 2017).

Simultaneous Hydrogen Bonds with Different Binding Modes: The Acceptor "Rules" but the Donor "Chooses".

This computational work studies the different hydrogen bond (HB) binding modes that can be established between neighbouring HB donors and acceptors in structures with relevance in catalysis and biology. To analyse the electronic effect on the σ-hole, unsubstituted HB donors and ones with two different substituents, an electron withdrawing (EWG), and an electron donating (EDG) group, were studied. Upon complexation, three different binding modes were observed: bifurcated, parallel, and zigzag.

Peripheral Blood Gene Expression Profile of Infants with Atopic Dermatitis.

To enhance the understanding of molecular mechanisms and mine previously unidentified biomarkers of pediatric atopic dermatitis, PBMC gene expression profiles were generated by RNA sequencing in infants with atopic dermatitis and age-matched controls. A total of 178 significantly differentially expressed genes (DEGs) (115 upregulations and 63 downregulations) were seen, compared with those in healthy controls. The DEGs identified included , , , , and .

Synthesis and Characterization of a Masked Terminal Nickel-Oxide Complex.

In exploring terminal nickel-oxo complexes, postulated to be the active oxidant in natural and non-natural oxidation reactions, we report the synthesis of the pseudo-trigonal bipyramidal Ni complexes (K)[Ni (L )(DMF)] (1[DMF]) and (NMe ) [Ni (L )(OAc)] (1[OAc]) (L =2,2',2''-nitrilo-tris-(N-phenylacetamide); DMF=N,N-dimethylformamide; OAc=acetate). Both complexes were characterized using NMR, FTIR, ESI-MS, and X-ray crystallography, showing the L ligand to bind in a tetradentate fashion, together with an ancillary donor. The reaction of 1[OAc] with peroxyphenyl acetic acid (PPAA) resulted in the formation of [(L )Ni -O-H⋅⋅⋅OAc] , 2, that displays many of the characteristics of a terminal Ni=O species.

Assessment of Morphological, Anatomical and Palynological Variation in the Medicinal Plant Craib (Asparagaceae) for Botanical Quality Control.

Craib is an Asian medicinal plant belonging to the Asparagaceae family. The plants are well known for their steroidal saponins and phenolic compounds and are traditionally used as tonics for back pain, bellyache, cough, diabetes, asthma, pneumonia and rheumatism. However, they are challenging to identify to species level using morphology.

Anomalous diffusion, gigahertz, and terahertz spectroscopy of aliphatic ketones.

The experimental results of the complex dielectric permittivity of aliphatic ketones in dilute solutions of inert solvent cyclohexane in the gigahertz (GHz) and terahertz (THz) frequencies of the electromagnetic spectrum are examined in terms of the theory of inertial anomalous diffusion of polar molecules, considered as an assembly of molecules with interacting dipolar groups, in polar liquids. The theory is based on the generalization of the Debye rotational diffusion model of dielectric relaxation of polar molecules. The model comprises two interacting dipolar groups-one lighter and the other heavier; each has a finite moment of inertia and each experiences a finite friction with an extensive range of damping or drag coefficient and the dipole moment ratio of the two groups.

Growing Up in the Great Recession: The Effects of Three Dimensions of Economic Well-being on Child Behavioral Difficulties from Ages 3 to 17.

Empirical research into the relationship between economic well-being and child outcomes has been limited by its cross-sectional nature, or its narrow focus on predominantly financial aspects of economic well-being. This article attempts to overcome these shortcomings by using data from the Growing Up in Ireland Cohort98 (age: 9-17; N = 5,748; female: 51.4%) and Cohort08 studies (age: 3-9 years; N = 7,208; female: 49.

The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice.

Background And Purpose: Neonatal seizures represent a clinical emergency. However, current anti-seizure medications fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of inflammation, and evidence suggests that P2X7R contributes to seizures and epilepsy in adults.

The Origin of Translation: Bridging the Nucleotides and Peptides.

Extant biology uses RNA to record genetic information and proteins to execute biochemical functions. Nucleotides are translated into amino acids via transfer RNA in the central dogma. tRNA is essential in translation as it connects the codon and the cognate amino acid.

Processing laser ablated plasmonic nanoparticle aerosols with nonthermal dielectric barrier discharge jets of argon and helium and plasma induced effects.

Dielectric-barrier-discharge (DBD) plasma jets provide viable state-of-the-art nonthermal processes for a wide range of nanomaterials including particle transport and deposition. We report the interaction of argon and helium plasma jets with the particle aerosol, produced by ns laser ablation of a silver target and subsequently their transport for deposition on a distant substrate. The nanofeatures and functionality of the nanoparticles, entrained and deposited with the two plasma jets were compared using high-resolution electron microscopy, helium ion microscopy, scanning electron microscopy, ultraviolet-visible spectroscopy, and in terms of the SERS effect.

What does a "good life" mean for people living with dementia? A protocol for a think-aloud study informing the value of care.

Introduction: Economic evaluation currently focuses almost exclusively on the maximization of health, using the Quality-Adjusted Life-Year (QALY) framework with instruments such as the EQ-5D, with a limited number of health-focused dimensions providing the assessment of health benefit. This evaluative framework is likely to be insufficient for setting priorities in dementia care because of its exclusive concern with health. Data are also often collected from the perspective of a proxy, limiting the voice of those living with dementia in decision-making.

Linear indium atom chains at graphene edges.

The presence of metal atoms at the edges of graphene nanoribbons (GNRs) opens new possibilities toward tailoring their physical properties. We present here formation and high-resolution characterization of indium (In) chains on the edges of graphene-supported GNRs. The GNRs are formed when adsorbed hydrocarbon contamination crystallizes via laser heating into small ribbon-like patches of a second graphitic layer on a continuous graphene monolayer and onto which In is subsequently physical vapor deposited.

Naming ability assessment in neurocognitive disorders: a clinician's perspective.

Background: Detecting impaired naming capacity is valuable in diagnosing neurocognitive disorders (ND). A. clinical practice- oriented overview of naming tests validated in ND is not available yet.

Analysing the Efficiency of Health Systems: A Systematic Review of the Literature.

Background: Efficiency refers the use of resources in ways that optimise desired outcomes. Health system efficiency is a priority concern for policy makers globally as countries aim to achieve universal health coverage, and face the additional challenge of an aging population. Efficiency analysis in the health sector has typically focused on the efficiency of healthcare facilities (hospitals, primary healthcare facilities), with few studies focusing on system level (national or sub-national) efficiency.

Accessing unsymmetrical Ru(II) bipyridine complexes: a versatile synthetic mechanism for fine tuning photophysical properties.

Three novel unsymmetrical Ru(II) bipyridine complexes were generated a convenient, modular, convergent synthetic route. An investigation of their photophysical properties revealed solvent-dependent excited state behaviour including altered absorption and emission wavelengths, emission lifetimes and quantum yields of phosphorescence.

Is epinephrine effective during neonatal resuscitation?

In the original research article published in Pediatric Research, Anderson et al provide valuable data from a placebo-controlled randomized trial on epinephrine in 12-hour-old piglets in cardiac arrest. In this commentary, we discuss briefly the existing evidence supporting use of epinephrine during neonatal resuscitation.

Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes.

The primary phase time constant of pulmonary oxygen uptake kinetics ( ) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply to active muscles. This study examined if a high-intensity "priming" exercise (PE) would speed during a subsequent high-intensity cycling exercise in T2D due to enhanced oxygen delivery. Eleven (4 women) middle-aged individuals with type 2 diabetes and 11 (4 women) non-diabetic controls completed four separate cycling bouts each starting at an 'unloaded' baseline of 10 W and transitioning to a high-intensity constant-load.

Musculoskeletal education in undergraduate medical curricula-A systematic review.

Rheumatic and musculoskeletal diseases encompass a vast spectrum of up to 200 conditions that are increasingly prevalent, with significant associated disability and socioeconomic burden. Their impact is pervasive, with musculoskeletal conditions being the second leading cause of years lived with disability worldwide, in addition to the 9th most common cause of disability-adjusted life years. It is therefore imperative that all graduating medical physicians are competent in their management, and that the quality of undergraduate musculoskeletal education is commensurate with patient and societal needs.

Purinergic Signalling and Inflammation-Related Diseases.

While acute inflammation is widely accepted as an important response mechanism of cells against tissue injury, sustained inflammatory processes are increasingly recognized as one of the main contributors to numerous diseases, including central-nervous system (CNS)-related and non-CNS-related diseases such as depression, neurodegenerative diseases, type 2 diabetes, hypertension, cardiovascular diseases, chronic kidney disease, osteoporosis, and cancer [...

Reviving the anatomic past: Breathing new life into historic anatomical teaching tools.

The last two decades have seen a shift in the way anatomy education is delivered. With the introduction of blended learning, cadaveric dissection is no longer the be all and end all and, in many cases, the continuing role of anatomical teaching artefacts has declined after decades of prominence. While some institutions have abandoned their archaic anatomical collections and medical museums completely, others have invested in their technological enhancement.