"The advice? Think bigger": Community perspectives on dairy farming, including surplus calves - an Australian focus group study.

Citizens are becoming increasingly disconnected from food production. Despite this, many people still hold strong values about how food is produced. The aim of this study was to attain an in-depth understanding of Australian public attitudes toward sustainability and animal welfare in dairy production, as well as early life killing of surplus dairy calves and cow-calf separation; issues commonly identified as being out of step with public values.

A novel serous ovarian carcinoma model induced by DMBA: Results from OncoTherad® (MRB-CFI-1) immunotherapy preclinical testing.

Aims: The term ovarian carcinoma (OC) refers to a heterogeneous collection of five distinct diseases known as histotypes. While histotype-specific treatment is still a clinical challenge in OC, well-characterized models are required for testing new therapeutic strategies. We employed OncoTherad® (MRB-CFI-1), an interferon (IFN-γ)-stimulating nano-immunotherapy mediated by Toll-like receptors (TLR) 2/4, in association or not with Erythropoietin (EPO) in a chemically-induced ovarian cancer model.

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Background: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.

Methods: Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test.

Long-term trajectories of physical activity behavior in adults with physical disabilities and/or chronic diseases following rehabilitation: the prospective cohort study ReSpAct 2.0.

Purpose: This study aimed to identify trajectories of physical activity behavior from discharge up to 6-8 years after rehabilitation among adults with physical disabilities and/or chronic diseases, and to determine modifiable determinants associated with trajectory membership.

Material And Methods: 390 Adults with physical disabilities and/or chronic diseases participated in the Rehabilitation, Sports and Active lifestyle (ReSpAct) 2.0 study with measurements at 3-6 weeks before discharge (T0), and 14 (T1), 33 (T2), and 52 weeks (T3), and 6-8 years (T4) after discharge from rehabilitation.

Women faculty members' challenges when pursuing leadership positions in academic dentistry: A survey.

Purpose/objectives: This study addresses persistent gender disparities in leadership roles in academic dentistry. The objectives were to identify the challenges and barriers to leadership that women face in general and during the COVID-19 pandemic, as well as to describe resources they need to reach their leadership potential.

Methods: The American Dental Education Association Section on Women in Leadership (WIL), gathered survey data concerning leadership challenges and faculty development needs.

Dyadic Resistance in Parent-Adolescent Interactions During the Transition to High School.

Introduction: Although prior research has examined adolescents' resistance to parental control, the dyadic level of analysis has been overlooked. This study attended to how a Canadian sample of parents and adolescents engaged in resisting one another by observing moment-to-moment actions as they discussed the upcoming transition to high school.

Methods: A secondary analysis of data collected from 2010 to 2012 using the Action-Project Method was conducted.

Adverse changes in close social ties in aging women and men: A population-based longitudinal study of the CLSA (2011-2021).

Close social ties are important for health but these can decline as people age. Moreover, losses of close social ties may be worse for women, older age and low socioeconomic groups. We characterized alterations in both marital status or living arrangement over 6 years by gender, and assessed patterns by age, country of origin, geographic location, education, wealth, and household income.

Automating Racism: Is Use of the Vaginal Birth After Cesarean Calculator Associated with Inequity in Perinatal Service Delivery?

Objective: The clinical application of race-adjusted algorithms may perpetuate health inequities. We assessed the impact of the vaginal birth after cesarean (VBAC) calculator, which was revised in 2021 to address concerns about equity. The original algorithm factored race and ethnicity and gave lower VBAC probabilities to Black and Hispanic patients.

Temperature governs the relative contributions of cuticle and stomata to leaf minimum conductance.

During periods of stomatal closure, such as drought, plant leaves continue to lose water at a rate determined by the minimum leaf conductance, g. Although g varies with temperature, less is known about what drives this variation, including how the pathways of water loss (cuticle or stomata) vary with temperature. We used gas exchange and bench drying methods to measure g and cuticular conductance, g, across a wide temperature range (20-50°C) in 11 broadleaf species.

Disabled Students in Health and Social Services Fieldwork: Perceptions of Canadian Fieldwork Educators and Academic Coordinators.

Ensuring equitable access to professional education programs for learners who need accommodations is distinctly challenging when education moves beyond the classroom into clinical or fieldwork sites. Fieldwork educators and university academic coordinators who arrange fieldwork placements work with university accessibility services and students to arrange required accommodations, while preserving confidentiality, maintaining high learning standards, and ensuring attainment of professional competencies. This work is complicated by time pressures and heavy caseloads in fieldwork settings.

Advancements in nanotechnology for diagnostics: a literature review, part II: advanced techniques in nuclear and optical imaging.

Modern molecular imaging routes, such as nuclear imaging and optical imaging, derive significant advantages from nanoparticles, where multimodality use and multipurpose are key benefits. Nanoparticles also showcase benefits over traditional imaging agents in nuclear and optical imaging, including improved resolution, penetration, and specificity. The goal of this literature review was to explore recent advancements in nanomaterials within these molecular imaging techniques to expand on the current state of nanomedicine in these modalities.

Toughening hydrogels through a multiscale hydrogen bonding network enabled by saccharides for a bio-machine interface.

Hydrogels have considerably emerged in a variety of fields, but their weak mechanical properties severely restrict the wide range of implementation. Herein, we propose a multiscale hydrogen bonding toughening strategy using saccharide-based materials to optimize the hydrogel network. The monosaccharide (glucose) at the molecular scale and polysaccharide (cellulose nanofibrils) at the nano/micro scale can effectively form hydrogen bonds across varied scales within the hydrogel network, leading to significantly enhanced mechanical properties.

Methodological review to develop a list of bias items for adaptive clinical trials: Protocol and rationale.

Background: Randomized-clinical trials (RCTs) are the gold-standard for comparing health care interventions, but can be limited by early termination, feasibility issues, and prolonged time to trial reporting. Adaptive clinical trials (ACTs), which are defined by pre-planned modifications and analyses that occur after starting patient recruitment, are gaining popularity as they can streamline trial design and time to reporting. As adaptive methodologies continue to be adopted by researchers, it will be critical to develop a risk of bias tool that evaluates the unique methodological features of ACTs so that their quality can be improved and standardized for the future.

Assessing the Necessity and Cost-effectiveness of Radiology Reports for Plain Hand Radiographs in Outpatient Clinics.

The purpose of this study was to determine the necessity and cost-effectiveness of radiologists' interpretation of plain hand radiographs for diagnosing and managing different hand pathologies in the plastic surgery outpatient clinic setting. Through a retrospective cohort study, we identified new patient encounters from January 2021 to December 2022 in an outpatient hand clinic. We included patients with radiology reports that were submitted subsequent to the surgeon's consult note in clinic.

Face Masking and Risk of Post-Intravitreal Injection Endophthalmitis: A Network Meta-Analysis of 2.6 Million Injections.

Topic: To compare face masking protocols for post-intravitreal injection endophthalmitis (PIE) prophylaxis.

Clinical Relevance: Though mask mandates are lifted, ophthalmologists may question whether continued investment into face masks will influence their PIE rate.

Methods/literature Reviewed: We included comparative studies of PIE incidence by masking policy (i.

In Situ Modulation of NiFeOOH Coordination Environment for Enhanced Electrocatalytic-Conversion of Glucose and Energy-Efficient Hydrogen Production.

Glucose electrocatalytic-conversion reaction (GCR) is a promising anode reaction to replace the slow oxygen evolution reaction (OER), thus promoting the development of hydrogen production by electrochemical water splitting. Herein, NiFe-based metal-organic framework (MOF) is used as a precursor to prepare W-doped nickel-iron phosphide (W-NiFeP) nanosheet arrays by ion exchange and phosphorylation, which exhibit a high electrocatalytic activity toward the hydrogen evolution reaction (HER), featuring an overpotential of only -179 mV to achieve the current density of 100 mA cm in alkaline media. Notably, electrochemical activation of W-NiFeP facilitates the in situ formation of phosphate groups producing W,P-NiFeOOH, which, in conjunction with the W co-doped amorphous layers, leads to a high electrocatalytic performance toward GCR, due to enhanced proton transfer and adsorption of reaction intermediates, as confirmed in experimental and theoretical studies.

'Mental heAlth and well-being in rUgby pLayers' (MAUL) study: an online survey of diverse cohorts of rugby union players internationally.

Introduction: Mental health and well-being is a relatively under-researched area in rugby, especially outside the elite men's game. Evidence suggests that physical activity and sports benefit mental health and well-being, and rugby provides health-enhancing moderate-to-vigorous physical activity.

Objective: This cross-sectional study used an online approach and engaged national rugby governing bodies to understand adult rugby players' mental health and well-being and increase the diversity of the current evidence base.

War exposure, daily stressors, and mental health 15 years on: implications of an ecological framework for addressing the mental health of conflict-affected populations.

Aims: Fifteen years ago, we published an article in seeking to resolve the contentious debate between advocates of two very different frameworks for understanding and addressing the mental health needs of conflict-affected populations. The two approaches, which we labelled and , reflect deeply held beliefs about the causes and nature of distress in war-affected communities. Drawing on the burgeoning literature on armed conflict and mental health, the reports of mental health and psychosocial support (MHPSS) staff in the field, and on research on the psychology and psychophysiology of stress, we proposed an integrative model that drew on the strengths of both frameworks and underscored their essential complementarity.

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage.

Background: The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.

Methods: We randomly assigned critically ill adults with acute aneurysmal subarachnoid hemorrhage and anemia to a liberal strategy (mandatory transfusion at a hemoglobin level of ≤10 g per deciliter) or a restrictive strategy (optional transfusion at a hemoglobin level of ≤8 g per deciliter). The primary outcome was an unfavorable neurologic outcome, defined as a score of 4 or higher on the modified Rankin scale (range, 0 to 6, with higher scores indicating greater disability) at 12 months.