2 results match your criteria: "The University of Arizona College of Medicine at Phoenix[Affiliation]"
Pituitary Abscess Causing Hypopituitarism in a Patient With Acquired Immunodeficiency Syndrome.
AACE Clin Case Rep
August 2022
Division of Endocrinology, Diabetes, and Metabolism, The University of Arizona College of Medicine at Phoenix, Phoenix, Arizona.
Article Synopsis
- * A 46-year-old woman with AIDS exhibited symptoms such as headaches and visual changes; imaging revealed a pituitary abscess, leading to treatment with antibiotics and hormones instead of surgery due to her immunocompromised condition.
- * This case highlights that adjacent infections can cause pituitary abscesses, and although antibiotics were effective in this situation, complete recovery of pituitary function was unlikely due to extensive damage.
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Oncogene
January 2020
Department of Medicine, The University of Arizona College of Medicine at Phoenix, Phoenix, USA.
Mitochondrial pyruvate carrier 1 (MPC-1) appears to be a tumor suppressor. In this study, we determined the regulation of MPC-1 expression by Lysine demethylase 5A (KDM5A) and critical impact of this novel KDM5A/MPC-1 signaling on PDA progression. TCGA database, paired PDA and adjacent normal pancreatic tissues, PDA tissue array and cell lines were used to determine the levels of MPC-1 and KDM5A expression, and their relationship with the clinicopathologic characteristics and overall survival (OS) of PDA patients.
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