Correction to: binomialRF: interpretable combinatoric efficiency of random forests to identify biomarker interactions.

An amendment to this paper has been published and can be accessed via the original article.

binomialRF: interpretable combinatoric efficiency of random forests to identify biomarker interactions.

Background: In this era of data science-driven bioinformatics, machine learning research has focused on feature selection as users want more interpretation and post-hoc analyses for biomarker detection. However, when there are more features (i.e.

The Case for Using Evidence-Based Guidelines in Setting Hospital and Public Health Policy.

Objective: Hospital systems and regulating agencies enforce strict guidelines barring personal items from entering the operating room (OR) - touting surgical site infections (SSIs) and patient safety as the rationale. We sought to determine whether or not evidence supporting this recommendation exists by reviewing available literature.

Background Data: Rules and guidelines that are not evidence based may lead to increased hospital expenses and limitations on healthcare provider autonomy.

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss.

Hearing loss is one of the most common human sensory disabilities, adversely affecting communication, socialization, mood, physical functioning, and quality of life. In addition to age and noise-induced damage, ototoxicity is a common cause of sensorineural hearing loss with chemotherapeutic agents, for example, cisplatin, being a major contributor. Zebrafish (Danio rerio) are an excellent model to study hearing loss as they have neurosensory hair cells on their body surface that are structurally similar to those within the human inner ear.

The Solid Component of Radiographically Non-Growing, Post-Radiated Vestibular Schwannoma Retains Proliferative Capacity: Implications for Patient Counseling.

Objective: Nearly all radiated vestibular schwannomas (VS) have solid tissue remaining at the radiation bed. The viability and proliferation capacity of this tissue has never been objectively assessed. The goals of our study were to (1) determine whether this tissue retains the morphological and immunohistochemical features of VS and (2) evaluate whether the tissue is capable of proliferation in cell culture.

The impact of cochlear implantation on cognition in older adults: a systematic review of clinical evidence.

Background: Hearing loss is the third most prevalent chronic condition faced by older adults and has been linked to difficulties in speech perception, activities of daily living, and social interaction. Recent studies have suggested a correlation between severity of hearing loss and an individual's cognitive function; however, a causative link has yet to be established. One intervention option for management of the most severe to profound hearing loss in older adults is cochlear implantation.

The submental island flap for reconstruction of temporal bone defects.

Objective: Untreated cutaneous malignancies involving the lateral aspect of the cranium often invade the temporal bone, necessitating a resection of this site. The reconstruction of the associated complex defect typically requires a reconstructive flap placement to obliterate the resection cavity and provide an aesthetically pleasing restoration. We performed a retrospective case review of 30 patients undergoing temporal bone resection and reconstruction with a submental island flap (SIF), free flap, or temporalis rotation flap.

Multicenter evaluation of the Cepheid Xpert methicillin-resistant Staphylococcus aureus (MRSA) test as a rapid screening method for detection of MRSA in nares.

The first U.S. multicenter clinical trial to assess the performance of the Cepheid Xpert MRSA assay (Xpert MRSA) was conducted.