Fabrication of a Dual-Targeted Liposome-Coated Mesoporous Silica Core-Shell Nanoassembly for Targeted Cancer Therapy.

Nanoparticles have been suggested as drug-delivery systems for chemotherapeutic drugs to allow for controlled drug release profiles and selectivity to target cancer cells. In addition, nanoparticles can be used for the in situ generation and amplification of reactive oxygen species (ROS), which have been shown to be a promising strategy for cancer treatment. Thus, a targeted nanoscale drug-delivery platform could be used to synergistically improve cancer treatment by the action of chemotherapeutic drugs and ROS generation.

Draft genomes of and coexisting within a female urinary bladder.

Here, we present the draft genome sequences of and , both isolated from the urinary bladder of an asymptomatic post-menopausal female patient with a diagnosis of recurrent urinary tract infections. These genomes will facilitate analyses of interbacterial interactions in the urinary microbiome.

Communicating Sex Work Online: A Content Analysis of Client and Provider Discourse in r/SexWorkers.

The growth of digital technologies has enabled the creation of online platforms for sex workers to share, create, and gather information. To elucidate how this community leverages social media, the current study analyzed how sex workers and related groups (e.g.

Nanoscale modeling of dynamically tunable planar optical absorbers utilizing InAs and InSb in metal-oxide-semiconductor-metal configurations.

The attainment of dynamic tunability in spectrally selective optical absorption has been a longstanding objective in modern optics. Typically, Fabry-Perot resonators comprising metal and semiconductor thin films have been employed for spectrally selective light absorption. In such resonators, the resonance wavelength can be altered via structural modifications.

Using Fume Hood to Reduce Nurses' Exposure to Particulate Matters Dispersed Into the Air During Pill Crushing.

Background: Pill crushing is a common practice in patient care settings. Crushing pills can disperse particulate matter (PM) into indoor air. The PM is a widespread air pollutant composed of microscopic particles and droplets of various sizes and may carry active and/or inactive ingredients nurses can inhale.

Implementation of a STI risk behavior reduction program for university students.

To implement a STI risk behavior reduction program to reduce sexual risk behaviors in university-aged students. Fifty-nine freshman from the university participated in the STI Risk Behavior Reduction program. Pre- and post-test design using descriptive statistics evaluated the STI Risk Behavior Reduction Program.

Extreme nonlinear optics in a long pulse regime: High harmonic generation of picosecond mid-IR pulses in polycrystalline zinc selenide.

High harmonic generation (HHG) in semiconductors has been extensively studied recently in the high-intensity limit using middle infrared (mid-IR) femtosecond laser pulses resulting in emission spectra of self-phase modulated harmonics resting on top of a broadband continuum. In this report, a different approach to HHG in polycrystalline zinc selenide (poly-ZnSe) was explored utilizing a relatively low power regime (1-40 GW/cm) and much longer (30 ps) mid-IR laser pulses. Through a combination of low power, picosecond excitation, and narrowband (<10 nm full width at half maximum) mid-IR excitation, the nonlinear optical effects in poly-ZnSe could be isolated and studied independently.

Using Biological Motion to Investigate Perceptual-Cognitive Expertise in Law Enforcement Use-of-Force Decisions.

Research focused on police officers' decision-making in ambiguous use-of-force situations has yet to investigate the role that a suspect's biological motion plays in unknown-object identification. The current study uses point-light displays to isolate the suspect's motion and remove potentially biasing information (e.g.

Inhibition of bromate formation in plasmon-enhanced catalytic ozonation over silver-doped spinel ferrite.

High energy consumption and formation of harmful byproducts are two challenges faced by advanced oxidation processes (AOPs). While much research efforts have been devoted to improving the treatment efficiency, byproduct formation and control calls for more attention. In this study, the underlying mechanism of bromate formation inhibition during a novel plasmon-enhanced catalytic ozonation process with silver-doped spinel ferrite (0.

Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers based on five-year survival rates. Genes contributing to chemoresistance represent novel therapeutic targets that can improve treatment response. Increased expression of ANGPTL4 in tumors correlates with poor outcomes in pancreatic cancer.

Genome Sequences of Bacteria Isolated from the International Space Station Water Systems.

We report draft genomes of five bacteria recovered from the U.S. and Russian water systems onboard the International Space Station.

Optimized photodegradation of palm oil agroindustry waste effluent using multivalent manganese-modified black titanium dioxide.

This article presents a methodological approach to use manganese (MnMn)-modified black titanium dioxide (Mn/BTiO) as a photocatalyst to optimize and improve visible-light-driven photodegradation of treated agro-industrial effluent (TPOME). A modified wet chemical process was used to prepare BTiO. The BTiO was then wet impregnated with Mn and calcined at 300 °C for 1 h to produce Mn/BTiO.

Urban effects on local cloud patterns.

Urbanization extensively modifies surface roughness and properties, impacting regional climate and hydrological cycles. Urban effects on temperature and precipitation have drawn considerable attention. These associated physical processes are also closely linked to clouds' formation and dynamics.

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas.

The delivery and accumulation of therapeutic drugs into cancer cells without affecting healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a liposomal hybrid gold nano-assembly with enhanced photothermal activity for lung cancer treatment. The core components of the nano-assembly include gold nanorods coated with a mesoporous silica shell that offers an excellent drug-loading surface for encapsulation of doxorubicin.

A Faculty Toolkit to Pilot Next Generation NCLEX-Style Exam Items in a Prelicensure Curriculum.

With the implementation of Next Generation NCLEX (NGN), many prelicensure nurse faculty feel unprepared to create examination items in the formats proposed. These formats are designed to meaningfully evaluate clinical judgment while providing learners experience with the NGN assessment format prior to their sitting for the licensure examination. This article presents one program's pilot of NGN-style exam items in three clinical courses.

Properties and Acceleration Mechanisms of Electrons Up To 200 keV Associated With a Flux Rope Pair and Reconnection X-Lines Around It in Earth's Plasma Sheet.

The properties and acceleration mechanisms of electrons (<200 keV) associated with a pair of tailward traveling flux ropes and accompanied reconnection X-lines in Earth's plasma sheet are investigated with MMS measurements. Energetic electrons are enhanced on both boundaries and core of the flux ropes. The power-law spectra of energetic electrons near the X-lines and in flux ropes are harder than those on flux rope boundaries.

Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Warb. (Myristicaceae).

is one of the genera in the Myristicaceae family. The genus includes 60 species in Southeast Asia and is traditionally used for treating skin disorders. Here, for the first time, the essential oil, anti-tyrosinase, and molecular docking studies of were evaluated.

Lianas increase lightning-caused disturbance severity in a tropical forest.

Lightning is an important agent of plant mortality and disturbance in forests. Lightning-caused disturbance is highly variable in terms of its area of effect and disturbance severity (i.e.