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Association of hormone replacement therapy with risk of gastric cancer: a systematic review and meta-analysis.
Sci Rep
July 2022
Department of Global Health Policy, Graduate School of Medicine, The University of 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Article Synopsis
- Hormone replacement therapy (HRT) is commonly used for relieving menopausal symptoms, but its link to gastric cancer was unclear until this study.
- Researchers conducted a systematic review and meta-analysis, analyzing 11 studies that included over 1.9 million women, which found that HRT use was associated with a 28% reduced risk of gastric cancer compared to non-users.
- The findings suggested a consistent reduction in gastric cancer risk for both estrogen-only and estrogen-progestin therapies, highlighting the need for future research to explore the mechanisms behind this association.