5 results match your criteria: "The University o[Affiliation]"
TGFβ signaling regulates epithelial-mesenchymal plasticity in ovarian cancer ascites-derived spheroids.
Endocr Relat Cancer
March 2016
Translational Ovarian Cancer Research ProgramLondon Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6Department of Anatomy and Cell BiologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of BiochemistrySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of Obstetrics and GynaecologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of OncologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada Translational Ovarian Cancer Research ProgramLondon Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6Department of Anatomy and Cell BiologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of BiochemistrySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of Obstetrics and GynaecologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of OncologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada Translational Ovarian Cancer Research ProgramLondon Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6Department of Anatomy and Cell BiologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of BiochemistrySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of Obstetrics and GynaecologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, CanadaDepartment of OncologySchulich School of Medicine and Dentistry, The University o
Epithelial-mesenchymal transition (EMT) serves as a key mechanism driving tumor cell migration, invasion, and metastasis in many carcinomas. Transforming growth factor-beta (TGFβ) signaling is implicated in several steps during cancer pathogenesis and acts as a classical inducer of EMT. Since epithelial ovarian cancer (EOC) cells have the potential to switch between epithelial and mesenchymal states during metastasis, we predicted that modulation of TGFβ signaling would significantly impact EMT and the malignant potential of EOC spheroid cells.
View Article and Find Full Text PDFDiagnostic labels, stigma, and participation in research related to dementia and mild cognitive impairment.
Res Gerontol Nurs
April 2009
Health and Community Systems Department, The University o Pittsburgh School of Nursing, 415 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, USA.
Health care professionals use diagnostic labels to classify individuals for both treatment and research purposes. Despite their clear benefits, diagnostic labels also serve as cues that activate stigma and stereotypes. Stigma associated with the diagnostic labels of dementia and mild cognitive impairment (MCI) can have a significant and negative impact on interpersonal relationships, interactions with the health care community, attitudes about service utilization, and participation in clinical research.
View Article and Find Full Text PDFThe first-trimester screen in clinical practice.
S D Med
October 2009
Sanford School of Medicine, The University o South Dakota, USA.
The first-trimester screen combines nuchal translucency measurement and serum levels ot PAPP-A and beta-hCG between 11 and 13 weeks gestational age which can be used to calculate the risk of fetal Trisomy 21 and 18. Although these trisomies are the most common conditions detected, recognition of increased risk for several other fetal conditions and maternal complications have also been documented. A common misconception is that requesting this test implies that the patient will automatically terminate an affected fetus.
View Article and Find Full Text PDFIntraretinal oxygen distribution in urethan-induced retinopathy in rats.
Am J Physiol
June 1998
Centre for Ophthalmology and Visual Science, The University o Western Australia, Nedlands 6009, Australia.
This study was performed to explore the interaction between chronic neural degeneration and the subsequent vascular remodeling. Weekly urethan administration in rats from birth produces a retinopathy model characterized by photoreceptor degeneration, retinal vascular regression, and retinal pigment epithelium (RPE) neovascularization. We investigated the hypothesis that altered oxygen distribution across the retina and choroid could be involved in the vascular changes seen in this retinopathy.
View Article and Find Full Text PDFConcomitant immunity in schistosomiasis.
Parasitol Today
January 1993
Department of Zoology, The University o f Glasgow, Scotland, UK G 12 8QQ.