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The expression and clinical significance of syncytin-1 in serum exosomes of hepatocellular carcinoma patients.
Open Life Sci
September 2024
The Third Provincial Hospital Affiliated to Shandong University, 250000, Jinan, Shandong, China.
Article Synopsis
- - The study explored the levels of syncytin-1 in serum exosomes from 61 hepatocellular carcinoma (HCC) patients and 61 healthy individuals to determine its clinical significance in diagnosis.
- - Results showed that syncytin-1 levels were significantly higher in HCC patients compared to the control group, with a sensitivity of 91.3% and specificity of 75.5%, outperforming the traditional marker alpha-fetoprotein.
- - Higher levels of syncytin-1 were also correlated with worse clinical features like lymph node metastasis and degree of differentiation in HCC patients, indicating its potential as a valuable tumor marker for early detection and staging.