Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China.

Background: Studies have shown the positive impact of perceived social support on cognitive function among older adults in rural areas. However, existing studies often overlook the impact of different support sources. This study aimed to explore the relationship between the diverse sources of perceived social support and cognitive function.

Longitudinal validation of cognitive reserve proxy measures: a cohort study in a rural Chinese community.

Background: While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR's stability over time and its relation to cognitive function in rural Chinese older adults.

Methods: Within the project on the health status of rural older adults (HSRO), the survey included baseline assessment (2019) and follow-up assessment (2022).

A bidirectional relationship between cognitive reserve and cognition among older adults in a rural Chinese community: a cross-lagged design.

Background: The concept of cognitive reserve (CR) plays a crucial role in understanding cognitive aging and resilience. Accumulating evidence revealed the influence of CR proxy on cognitive function, but it remains unknown whether a reverse association or reciprocal effect exists.

Objective: The aim of this study is to observe the bidirectional relationship between cognitive reserve proxies and cognitive function among older adults in rural Chinese communities, providing a better understanding of the underlying mechanisms and potential moderating factors involved.

Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults.

Accumulated evidence showed that thyroid diseases induced cognitive decline. However, the relationship between thyroid hormones (THs) and cognition in older euthyroid people is still unclear. Our study aimed to estimate the association between THs within the euthyroid range and cognition in community-dwelling older adults in China.

A Modified Suture Technique to Improve Scar Appearance in Wounds Under High Tension.

The purpose of this study was to introduce a modified suture technique and to compare its effects on skin scar formation with 2 traditional suture methods: simple interrupted suture (SIS) and vertical mattress suture (VMS). Three groups of healthy adult female Sprague-Dawley rats were selected (6 replicates in each group), and the full-thickness skin of 5 cm × 0.2 cm was cut off on the back of the rats after anesthesia.

Genetically predicted higher educational attainment decreases the risk of stroke: a multivariable Mendelian randomization study.

Background: The causal association between educational attainment (EA) and stroke remains unclear. Hence, a novel multivariable Mendelian randomization (MVMR) approach was applied to solve this issue.

Methods: The single nucleotide polymorphisms (SNPs) from a recent genome-wide association study (GWAS) on years of schooling served as instruments.

Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2.

COVID-19 patients with comorbidities such as hypertension or heart failure (HF) are associated with poor clinical outcomes. The cellular distribution of Angiotensin-converting enzyme 2 (ACE2), the critical enzyme for SARS-CoV-2 infection, in the human heart is unknown. We explore the underlying mechanism that leads to increased susceptibility to SARS-CoV-2 in patients with cardiovascular diseases and patients of cardiac dysfunction have increased risk of multi-organ injury compared with patients of normal cardiac function.

Machine-learning based radiogenomics analysis of MRI features and metagenes in glioblastoma multiforme patients with different survival time.

Background: This study aimed to examine multi-dimensional MRI features' predictability on survival outcome and associations with differentially expressed Genes (RNA Sequencing) in groups of glioblastoma multiforme (GBM) patients.

Methods: Radiomics features were extracted from segmented lesions of T2-FLAIR MRI data of 137 GBM patients. Radiomics features include intensity, shape and textural features in seven classes were included in the analysis.

Impacts of triamcinolone acetonide on femoral head chondrocytic structures in lumbosacral plexus block.

To investigate impacts of triamcinolone acetonide (TRI) on femoral head chondrocytic (FHC) structures when used for lumbosacral plexus block (LPB). A total of 32 6-month-old New Zealand white rabbits were selected (averagely weighing 2.75-3.