3 results match your criteria: "The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University[Affiliation]"
MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway to Attenuate Burn-Induced Acute Lung Injury in Rats.
Biomed Environ Sci
September 2024
The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Department of Burn and Plastic Surgery, Bengbu 230000, Anhui, China.
Article Synopsis
- * Experiments on rat models demonstrated that inhibiting miR-451 led to increased TSC1 levels and changes in the mTOR pathway, suggesting that miR-451 regulates these processes to mitigate ALI.
- * The findings indicate a potential new treatment approach for ALI by targeting the TSC1/mTOR signaling pathway through miR-451, emphasizing the role of autophagy in macrophages.
Hypoxia-Associated GPNMB+ Macrophages Promote Malignant Progression of Colorectal Cancer and Its Related Risk Signature Are Powerful Predictive Tool for the Treatment of Colorectal Cancer Patients.
Environ Toxicol
October 2024
Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Bengbu, China.
Colorectal cancer (CRC) is a highly malignant tumor with hypoxia being a crucial feature during its progression. This study utilized multiple independent CRC cohorts for bioinformatics analysis and in vitro experiments to investigate the role of hypoxia-related subgroups in CRC. Machine learning was employed to construct risk features associated with this subgroup and further explore its therapeutic value in CRC.
View Article and Find Full Text PDFHuman umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis.
Acta Histochem
October 2024
Department of Burn and Plastic Surgery, The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu 233000, China. Electronic address:
Our previous study has shown that exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs-exo) alleviated burn-induced acute lung injury (ALI). In this study, we explored a novel mechanism by which hUCMSCs-exo contributed to the inhibition of burn-induced ALI. The ALI rat model with severe burn was established for the in vivo experiments, and rats PMVECs were stimulated with the serum from burn-induced ALI rats for the in vitro experiments.
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