8 results match your criteria: "The Third Medical Center of the General Hospital of the People's Liberation Army[Affiliation]"
A plain language summary of results from the TORCHLIGHT trial of toripalimab plus chemotherapy for metastatic or recurrent triple-negative breast cancer.
Future Oncol
December 2024
TopAlliance Biosciences, Rockville, MD, USA.
Guidelines and consensus: Jejunoileostomy for diabetes mellitus-surgical norms and expert consensus (2023 version).
World J Diabetes
November 2024
Department of General Surgery, The Third Medical Center of the General Hospital of the People's Liberation Army, Beijing 100039, China.
Article Synopsis
- Diabetes mellitus (DM) is a condition marked by high blood sugar levels due to inadequate insulin production, requiring patients to undergo long-term treatment with existing hypoglycemic drugs, which are often ineffective for managing the disease.
- Traditional weight loss surgeries, like gastric bypass, have strict BMI requirements and can lead to complications such as hypoglycemia and dumping syndrome, reducing their effectiveness for DM treatment.
- Jejunoileostomy is a newer surgical option showing promise for improving glucose and lipid metabolism without altering the gastrointestinal structure, resulting in fewer complications and better management of DM-related issues, supported by clinical consensus on its surgical and postoperative management.
Diagnosis and treatment of anterior cruciate ligament injuries: Consensus of Chinese experts part II: Graft selection and clinical outcome evaluation.
J Orthop Translat
September 2024
Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China.
Article Synopsis
- There has been significant progress in diagnosing and treating ACL injuries in China, with ACL reconstruction widely recognized for restoring knee stability, though standardized protocols are still needed.
- The Chinese Association of Orthopaedic Surgeons and the Chinese Society of Sports Medicine collaborated to create an expert consensus aimed at improving diagnostic and treatment standards for ACL injuries.
- Experts focused on "Graft Selection" and "Clinical Outcome Evaluation" during the consensus development, concluding that while there is no definitive graft choice, each option has its benefits and drawbacks regarding healing, availability, costs, and risks, particularly for young athletes.
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial.
Nat Med
January 2024
TopAlliance Biosciences, Rockville, MD, USA.
Article Synopsis
- The TORCHLIGHT trial tested the combination of the immune-checkpoint inhibitor toripalimab and nab-paclitaxel (nab-P) against a placebo with nab-P in patients with advanced triple-negative breast cancer (TNBC).
- Results showed that the toripalimab group had a significantly longer progression-free survival (PFS) of 8.4 months compared to 5.6 months for the placebo group, particularly in PD-L1-positive patients.
- The overall survival was also better for the toripalimab group (32.8 months vs. 19.5 months), and the safety profile was similar between groups, suggesting that toripalimab is a promising treatment for this cancer type.
Progression of Gastrointestinal Injury During Antiplatelet Therapy After Percutaneous Coronary Intervention: A Secondary Analysis of the OPT-PEACE Randomized Clinical Trial.
JAMA Netw Open
November 2023
Mount Sinai Heart and the Cardiovascular Research Foundation, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Gastrointestinal injury progression induced by antiplatelet therapy in patients after percutaneous coronary intervention (PCI) has not been well studied.
Objective: To assess the association of aspirin, clopidogrel, and their combination with gastrointestinal injury progression among patients without high bleeding risk after PCI.
Design, Setting, And Participants: This secondary analysis assessed data from the Optimal Antiplatelet Therapy for Prevention of Gastrointestinal Injury Evaluated by ANKON Magnetically Controlled Capsule Endoscopy (OPT-PEACE) double-masked, placebo-controlled, multicenter randomized clinical trial.
Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts.
Biomaterials
June 2023
Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong, 518055, PR China. Electronic address:
The off-the-shelf small-diameter vascular grafts (SDVGs) have inferior clinical efficacy. Red blood cell membrane (Rm) has easy availability and multiple bioactive components (such as phospholipids, proteins, and glycoproteins), which can improve the clinic's availability and patency of SDVGs. Here we developed a facile approach to preparing an Rm-functionalized poly-ε-caprolactone/poly-d-lysine (Rm@PCL/PDL) tube by co-incubation and single-step rolling.
View Article and Find Full Text PDFMagnetically Controlled Capsule Endoscopy for Assessment of Antiplatelet Therapy-Induced Gastrointestinal Injury.
J Am Coll Cardiol
January 2022
Icahn School of Medicine at Mount Sinai, Mount Sinai Heart and the Cardiovascular Research Foundation, New York, New York, USA.
Background: Gastrointestinal bleeding is the most frequent major complication of antiplatelet therapy. In patients at low bleeding risk, however, clinically overt gastrointestinal bleeding is relatively uncommon.
Objectives: The authors sought to assess the effects of different antiplatelet regimens on gastrointestinal mucosal injury by means of a novel magnetically controlled capsule endoscopy system in patients at low bleeding risk.
Reciprocal control of ADAM17/EGFR/Akt signaling and miR-145 drives GBM invasiveness.
J Neurooncol
April 2020
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, People's Republic of China.
Introduction: Glioblastoma multiforme (GBM) is one of the most devastating brain malignancies worldwide and is considered to be incurable. However, the mechanisms underlying its aggressiveness remain unclear.
Methods: The expression of ADAM17 in tissue samples was detected by immunohistochemistry.