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The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease.
Int J Clin Exp Pathol
September 2016
Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China.
Background: It has been reported that one single nucleotide polymorphisms (SNPs) rs5743708 in TLR2 gene might be associated with the susceptibility to tuberculosis disease. Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the rs5743708 gene polymorphism in the TLR2 gene and the risk of tuberculosis disease.
Methods: A systematic search of studies on the association of the rs5743708 gene polymorphism in the TLR2 gene with susceptibility to tuberculosis disease was conducted in PubMed.