5 results match your criteria: "The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang)[Affiliation]"
Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis.
Cell Chem Biol
December 2024
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Department of Immunology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China. Electronic address:
Article Synopsis
- Gasdermin D (GSDMD) is a key player in inflammatory diseases and cancer, making it a significant target for drug development.
- Current GSDMD inhibitors, like necrosulfonamide, mainly work by modifying specific cysteine residues, which can lead to unwanted side effects.
- This study identifies two safe, repurposed drugs that effectively inhibit GSDMD-mediated pyroptosis, showing potential for enhanced therapeutic effects in treating sepsis and tumors.
Analysis of factors influencing the recurrence of diabetic foot ulcers.
Skin Res Technol
July 2024
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang), Nanchang, Jiangxi, China.
Objective: The aim of this study is to investigate the factors influencing the recurrence of diabetic foot ulcers (DFU) and provide guidance for reducing the recurrence rate.
Methods: A total of 211 patients diagnosed with DFU who were hospitalized and discharged from the hospital from October 2015 to January 2020 were included as the study cohort. Participants were divided into two groups according to whether the foot ulcer recurred during the 2-year follow-up period: a recurrence group (n = 84) and a non-recurrence group (n = 127).
Metal copper and silver revealed potent antimicrobial activity for treating infected with .
Am J Transl Res
May 2024
Department of Clinical Laboratory, The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang) Nanchang 330008, Jiangxi, P. R. China.
Objectives: The increasing issue of bacterial resistance, coupled with inadequate progress in developing new antibiotics, necessitates exploring alternative treatments. Antibacterial biomaterials, such as silver and copper, possess advantageous properties such as heat resistance, durability, continuity, and safety. Particularly, they can effectively eliminate pathogenic bacteria while preserving cellular integrity, emphasizing the necessity of identifying optimal metal ion concentrations for practical application.
View Article and Find Full Text PDFThe interaction between ETS transcription factor family members and microRNAs: A novel approach to cancer therapy.
Biomed Pharmacother
June 2022
Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University & The First Hospital of Nanchang, Nanchang 330008, China. Electronic address:
In cancer biology, ETS transcription factors promote tumorigenesis by mediating transcriptional regulation of numerous genes via the conserved ETS DNA-binding domain. MicroRNAs (miRNAs) act as posttranscriptional regulators to regulate various tumor-promoting or tumor-suppressing factors. Interactions between ETS factors and miRNAs regulate complex tumor-promoting and tumor-suppressing networks.
View Article and Find Full Text PDFMicroRNA-425-3p inhibits myocardial inflammation and cardiomyocyte apoptosis in mice with viral myocarditis through targeting TGF-β1.
Immun Inflamm Dis
March 2021
Department of Pediatrics, XD Group Hospital, Xi'an, Shaanxi, China.
Objective: Emerging articles have profiled the relations between microRNAs and viral myocarditis. This research was unearthed to explore the capacity of miR-425-3p on cardiomyocyte apoptosis in mice with viral myocarditis and its mechanism.
Methods: A total of 120 mice were classified into 4 groups in a random fashion (n = 30).