Quantification of biological range uncertainties in patients treated at the Krakow proton therapy centre.

Background: Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a method to quantify the biological range extension of the proton beam, which results from the application of vRBE approach in RBE-weighted dose calculation.

Methods And Materials: The treatment plans of 95 patients (brain and skull base patients) were used for RBE-weighted dose calculation with constant and the McNamara RBE model.

Conductive Geopolymers as Low-Cost Electrode Materials for Microbial Fuel Cells.

Geopolymer (GP) inorganic binders have a superior acid resistance compared to conventional cement (, Portland cement, PC) binders, have better microbial compatibility, and are suitable for introducing electrically conductive additives to improve electron and ion transfer properties. In this study, GP-graphite (GPG) composites and PC-graphite (PCG) composites with a graphite content of 1-10 vol % were prepared and characterized. The electrical conductivity percolation threshold of the GPG and PCG composites was around 7 and 8 vol %, respectively.

Study of relationship between dose, LET and the risk of brain necrosis after proton therapy for skull base tumors.

Purpose: We investigated the relationship between RBE-weighted dose (DRBE) calculated with constant (cRBE) and variable RBE (vRBE), dose-averaged linear energy transfer (LETd) and the risk of radiographic changes in skull base patients treated with protons.

Methods: Clinical treatment plans of 45 patients were recalculated with Monte Carlo tool FRED. Radiographic changes (i.

Nanoparticle Tracing during Laser Powder Bed Fusion of Oxide Dispersion Strengthened Steels.

The control of nanoparticle agglomeration during the fabrication of oxide dispersion strengthened steels is a key factor in maximizing their mechanical and high temperature reinforcement properties. However, the characterization of the nanoparticle evolution during processing represents a challenge due to the lack of experimental methodologies that allow in situ evaluation during laser powder bed fusion (LPBF) of nanoparticle-additivated steel powders. To address this problem, a simulation scheme is proposed to trace the drift and the interactions of the nanoparticles in the melt pool by joint heat-melt-microstructure-coupled phase-field simulation with nanoparticle kinematics.

Evidence for interactions across frequency channels in the inferior colliculus of awake chinchilla.

As a result of cochlear processing, information about acoustic broadband signals is distributed across many parallel frequency channels. Periodic modulations of signal envelopes - conspicuous in particular in harmonic signals - may extend across a wide frequency range and give rise to temporal response patterns in the auditory nerve, particularly useful for recombination of constituents and the separation of the signals from background noise. Herein we report evidence that across frequency processing as necessary for binding of related signal components occurs already in the auditory midbrain of mammals.