Comparative evaluation of the wear resistance of two different implant abutment materials after cyclic loading - An in vitro study.

Purpose: To comparatively evaluate the wear resistance of two different implant abutment materials with titanium implants after cyclic loading.

Methodology: Two groups utilizing 20 titanium implants secured in resin blocks, in which 10 titanium implants are connected with titanium abutments (Group I, = 10) and the other 10 titanium implants are connected with Polyether ether Ketone (PEEK) abutments (Group II, = 10). Abutments are cyclically loaded for 550,000 cycles.

The Effect of Hypomagnesemia on Refractory Hypocalcemia after Total Thyroidectomy: A Single-Center Prospective Cohort Study.

Background: Hypomagnesemia is known to impede hypocalcemia correction. This prospective observational study aimed to evaluate the impact of serum magnesium levels on the development of refractory hypocalcemia, which remains a concerning problem after total thyroidectomy (TT).

Subjects And Methods: Consecutive subjects ( = 312; mean age = 38.

The impact of operative duration and intraoperative fluid dynamics on postoperative hypocalcemia after total thyroidectomy: a prospective non-randomized study.

Background: Postoperative hypocalcemia after total thyroidectomy (TT) still remains common. This prospective observation study examined the role of intraoperative time period (IOP) and intravenous fluids (IVF) in transient and permanent (> 6 months) hypocalcemia post-TT.

Subjects And Method: Consecutive patients (n = 328; age = median (IQR); 34 (15) years; M:F = 65:263) with benign or malignant thyroid disease undergoing TT were evaluated for IOP, intraoperative IVF, serum corrected calcium, intact parathormone (iPTH), and 25-hydroxyvitamin D (25OHD) levels at baseline, 48 h, and 6 months post-TT.

Repurposing of Benzimidazole Scaffolds for HER2 Positive Breast Cancer Therapy: An Approach.

Background: A newer trend has been seen recently to reuse the conventional drugs with distinct indications for the newer applications to speed up the drug discovery and development based on earlier records and safety data. Most of the non-cancerous agents could afford a little or tolerable side effects in individuals. However, the repositioning of these non-cancerous agents for successful anticancer therapy is an outstanding strategy for future anti-cancer drug development.

Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders.

Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate microenvironment, impairing the transport of many therapeutics into the CNS and making the management of common neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebrovascular diseases (CVDs) and traumatic brain injury (TBI), exceptionally complicated. Nanoparticle (NP) technology offers a platform for the design of tissue-specific drug carrying systems owing to its versatile and modifiable nature.

Lung Barrier Function in COVID-19?

The novel coronavirus COVID-19 appears to strike some people more intensely than others. Some people only experience mild symptoms while others require hospitalization and ventilation. With the virus becoming more prevalent day by day, it is not just the elderly, but even young people are falling seriously ill.

Effects of hot foot and arm bath in bronchial asthma: A single case report.

Background: Managing the condition of corticosteroid resistant asthmatic patients is quite difficult and challenging despite the plethora of new and modern medications. Hot Foot and Arm Bath (HFAB) is a widely used treatment modality for the management of bronchial asthma in Naturopathy. However, no scientific documentation or study is available so far assessing its effectiveness.

Molecular Modelling, Synthesis and Evaluation of Flavone and Flavanone Scaffolds as Anti-inflammatory Agents.

Objective: The objective of the study was to develop new Cyclooxygenase-2 inhibitors as anti-inflammatory agents from the synthetic route.

Materials And Methods: The 2-phenyl-4H-chromen-4-one and 2-phenyl-2,3-dihydro-4H-chromenone hybrids were synthesised and characterised by using UV, IR, H-NMR, and mass spectrometry. An attempt was made for consolidated lead flavones and flavanones scaffolds by determining ADME/ T properties.

Adhesive capsulitis: MRI correlation with clinical stages and proposal of MRI staging.

Objective: The purpose of this study was to correlate the magnetic resonance imaging (MRI) findings of adhesive capsulitis with clinical stages and thereby propose a MR staging system.

Materials And Methods: This study consisted of 74 patients with clinically diagnosed adhesive capsulitis. The edema of the inferior glenohumeral ligament (IGHL), pericapsular edema, thickness of anterior band of IGHL, axillary pouch, thickness of coracohumeral ligament, and obliteration of fat in the subcoracoid triangle were evaluated by MRI.

Post-Renal Transplant Metabolic Acidosis: A Neglected Entity.

Metabolic acidosis is a prevalent yet overlooked entity among renal transplant recipients (RTRs) and incurs adverse effects on graft function. Although graft dysfunction and calcineurin inhibitor usage have been linked with renal tubular acidosis (RTA), there is no Indian data on prevalence or risk factors of post-transplant acidosis. A cross-sectional study was conducted on 106 adult RTRs, with a transplant duration of >6 months and an estimated glomerular filtration rate (GFR) >40 ml/min/1.

The effect of total thyroidectomy on the recovery of bone mineral density in subjects with hyperthyroidism.

Background: Although hyperthyroidism is associated with high turnover osteopenia and its recovery after treatment, the extent of recovery with different forms of therapy remains controversial. This prospective study evaluated the bone mineral density in thyrotoxic subjects undergoing total thyroidectomy and I radioactive iodine therapy.

Methods: Newly diagnosed subjects with hyperthyroidism undergoing total thyroidectomy (group 1; n = 127) and I radioactive iodine therapy (group 2; n = 30) were evaluated for bone mineral density by dual energy x-ray absorptiometry at the time of diagnosis (point A), on achieving euthyroidism with antithyroid drugs (point B), and 6 months after definitive treatment (point C).

Spectrum of Hypokalemic Paralysis from a Tertiary Care Center in India.

Hypokalemic paralysis is an important and reversible cause of acute flaccid paralysis. The treating physician faces unique diagnostic and therapeutic challenges. We did a prospective study and included all patients with acute flaccid weakness and documented serum potassium of <3.

Evidence for a hyper-reductive redox in a sub-set of heart failure patients.

Background: Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) condition.

Carbapenem-resistant Enterobacteriaceae in Pediatric Bloodstream Infections in Rural Southern India.

Objective: To measure the frequency of antimicrobial resistance in pediatric blood culture isolates of Escherichia coli and Klebsiella spp. with focus on carbapenem resistance.

Methods: Over a period of three years, pediatric blood culture isolates were tested for antimicrobial susceptibility, including molecular investigations for carbapenem resistance.

Vignette hyperparathyroidism: glimpse into its history.

The parathyroid gland was first described by Sir Richard Owen. Ivor Sandstrom coined the term glandulae parathyroidiae. Vassale and Generali Francesco observed that tetany occurs following parathyroidectomy.

Recent trends in HIV prevalence in a remote setting of southern India: insights into arranging HIV control policies.

Introduction: Constant vigilance of the dynamics of HIV prevalence is important in estimating, regulating, and implementing prevention programs. The objective of this study was to investigate the trend in the prevalence of HIV infection over six years among specific demographic groups in the remote district of southern India.

Methodology: All high-risk attendees of the Integrated Counseling and Testing Centre, Government Theni Medical College between April 2005 and December 2010 were included in this study.

Vignette thyroid surgery: a glimpse into its history.

At present, physicians and surgeons treating thyroid disorders can rely on highly accurate and precise investigations, modern equipment, and state of the art operating theater to achieve optimum results; however, this was not the case at the beginning of the treatment of thyroid diseases centuries ago. We present a short history of the treatment and understanding of thyroid diseases in the past few decades. Also we present the contributions of the important surgeons who tried to perfect the treatment of thyroid diseases, including surgery, thus making modern day management easier.

In vitro evaluation of the effect of deproteinization on the marginal leakage of resin restorations using three bonding agents.

Background: The perfect sealing of the tooth/restoration interface is important to prevent bacteria penetration that may lead to secondary caries and also, when dentin is involved, prevent excessive fluid movement in the dentinal tubules that may cause hypersensitivity. The aim of this study was to evaluate the effect of deproteinization and application of reducing agent on the marginal integrity of composite restorations using three different bonding agents (Prime & Bond NT, AdheSE and G-Bond).

Materials And Methods: Class V cavities were prepared on the buccal surface of 90 recently extracted human premolars and were divided into three groups (I, II, and III) based on the adhesives.

Hematological changes following early ligation of splenic artery during splenectomy in shunt surgery for portal hypertension.

Objective And Background Data: Reduction in cellular elements of blood, secondary to hypersplenism is an established component of non-cirrhotic portal hypertension. Prior transfusion of blood or blood components is frequently required for safe surgical intervention. Due to thrombocytopenia, epidural catheter insertion for effective and durable analgesia is not possible.

Evaluation of estrogen receptor and circulating estradiol levels in pre- and postmenopausal women with periodontal disease.

Although the presence of estrogen receptors (ERs) in the gingival tissues has been confirmed, there is as yet insufficient literature regarding its expression in periodontal health and disease. Gingival samples were collected from 40 subjects who were divided into four groups. (Group A, premenopausal health; Group B, premenopausal periodontitis; Group C, postmenopausal health; Group D, postmenopausal periodontitis).

Management of esophageal perforation: experience from a tertiary center in India.

Background/aim: The management of esophageal perforations remains controversial in large part due to variability in etiology, time of presentation, location, and underlying esophageal disease. We reviewed our experience in treating patients with esophageal perforations and evaluated the etiology, management and outcome of intervention in a tertiary center.

Methods: Between 1999 and 2007, 48 patients with esophageal perforation were treated in a tertiary referral center in southern India.

The use of dried blood spots on filter paper for the diagnosis of HIV-1 in infants born to HIV seropositive women.

Polymerase chain reaction (PCR) is the most sensitive test to diagnose HIV-1 infection among infants born to HIV seropositive mothers. The purpose of this study was to evaluate the use of dried blood spot (DBS) specimens for PCR and to compare it with whole-blood stored in tubes for HIV-1 DNA PCR. Five hundred and seventy-seven whole-blood infant samples were tested using HIV-1 qualitative in-house nested DNA PCR.