38 results match your criteria: "The State University of New York Upstate Medical University[Affiliation]"

Plasma cell-rich acute rejection (PCAR), a relatively rare subtype of acute allograft rejection, is usually associated with a significantly lower treatment response rate and a higher graft failure rate. PCAR is characterized by the presence of more than 10% of plasma cells out of all graft infiltrating cells, with approximately 40%-60% of PCAR resulting in graft failure within a year. Currently, there is no gold standard for the effective treatment of PCAR.

View Article and Find Full Text PDF

Monocytes are circulating macrophage precursors generated from bone marrow hematopoietic stem cells. In adults, monocytes continuously replenish cerebral border-associated macrophages under physiological conditions. Monocytes also rapidly infiltrate the brain in pathological settings.

View Article and Find Full Text PDF

A novel hyperparameter search approach for accuracy and simplicity in disease prediction risk scoring.

J Am Med Inform Assoc

August 2024

Center for Health Systems Innovation, Department of Management Science and Information Systems, Oklahoma State University, Stillwater, OK 74078, United States.

Objective: Develop a novel technique to identify an optimal number of regression units corresponding to a single risk point, while creating risk scoring systems from logistic regression-based disease predictive models. The optimal value of this hyperparameter balances simplicity and accuracy, yielding risk scores of small scale and high accuracy for patient risk stratification.

Materials And Methods: The proposed technique applies an adapted line search across all potential hyperparameter values.

View Article and Find Full Text PDF

Reactive Angioendotheliomatosis Following Ad26.COV2.S Vaccination.

Cutis

December 2023

Collin Faulkner is from the State University of New York at Buffalo. Dr. Jabbour is from the State University of New York Upstate Medical University, Syracuse. Dr. Kanik is from CBLPath, Rye Brook, New York. Dr. Schoeneck is from FamilyCare Medical Group, Camillus, New York. Dr. Tangoren is from I. A. Tangoren, MD, PLLC, Dermatology & Dermatologic Surgery, Syracuse.

View Article and Find Full Text PDF

Purpose: To compare the port infection rate between single-lumen (SL) and double-lumen (DL) ports and to determine whether the use of a DL port is an independent risk factor for port infection among patients with cancer.

Materials And Methods: This retrospective study included 2,573 adult oncologic patients (aged >18 years) who had either a SL (n = 841) or a DL (n = 1,732) chest port implanted between 2013 and 2020 at a single institution. Patients who had port infection, including port-site infection and port-related bloodstream infection, were identified through chart review.

View Article and Find Full Text PDF

Histology diagnosis is essential for the monitoring and management of kidney transplant patients. Nowadays, the accuracy and reproducibility of histology have been criticized when compared with molecular microscopy diagnostic system (MMDx). Our cohort included 95 renal allograft biopsies with both histology and molecular diagnoses.

View Article and Find Full Text PDF

Objective: Spontaneous intracranial hypotension (SIH) remains a rare and difficult clinical entity to diagnose and treat. Epidural blood patch (EBP) of the dural sac is the mainstay definitive treatment for refractory cases and has mixed efficacy. We sought to evaluate the recent efficacy and outcomes of EBP for SIH at our institution.

View Article and Find Full Text PDF

The COVID-19 pandemic severely affected the medical education worldwide. The infection risk for medical students and healthcare personnel who work with COVID-19 positive cadavers or tissues remains unclear. Moreover, COVID-19 positive cadavers have been rejected by medical schools, adversely impacting the continuum of medical education.

View Article and Find Full Text PDF

Cross-modal attention for multi-modal image registration.

Med Image Anal

November 2022

Department of Biomedical Engineering and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address:

In the past few years, convolutional neural networks (CNNs) have been proven powerful in extracting image features crucial for medical image registration. However, challenging applications and recent advances in computer vision suggest that CNNs are limited in their ability to understand the spatial correspondence between features, which is at the core of image registration. The issue is further exaggerated when it comes to multi-modal image registration, where the appearances of input images can differ significantly.

View Article and Find Full Text PDF

Polar transform network for prostate ultrasound segmentation with uncertainty estimation.

Med Image Anal

May 2022

Department of Biomedical Engineering and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address:

Automatic and accurate prostate ultrasound segmentation is a long-standing and challenging problem due to the severe noise and ambiguous/missing prostate boundaries. In this work, we propose a novel polar transform network (PTN) to handle this problem from a fundamentally new perspective, where the prostate is represented and segmented in the polar coordinate space rather than the original image grid space. This new representation gives a prostate volume, especially the most challenging apex and base sub-areas, much denser samples than the background and thus facilitate the learning of discriminative features for accurate prostate segmentation.

View Article and Find Full Text PDF

Objective: To determine whether the proportion of sport-related concussion (SRC) cases among student athletes that resulted in a relapse of their symptoms due to premature return to play (RTP) or premature return to learn (RTL) has changed compared with a prior (2006 to 2011) study.

Design: Retrospective cohort study of electronic medical record charts from a 5-year period (2011 to 2016) compared with previous data.

Setting: A sport and exercise medicine physician's office-based practice in Ontario.

View Article and Find Full Text PDF

Background: Failure to find and attract clinical trial participants remains a persistent barrier to clinical research. Researchers increasingly complement recruitment methods with social media-based methods. We hypothesized that user-generated data from cancer survivors and their family members and friends on the social network Twitter could be used to identify, engage, and recruit cancer survivors for cancer trials.

View Article and Find Full Text PDF

Lack of Additional Advanced Graduate Training by Orthopaedic Surgeons in Academic Practice: Current Employment and Recruitment Trends.

J Am Acad Orthop Surg Glob Res Rev

May 2020

From the Department of Orthopaedics and Rehabilitation (Dr. Anderson, Dr. Kuhns, Dr. Schwarz, Dr. Rubery, Dr. Mannava), University of Rochester, Rochester; and the State University of New York Upstate Medical University (Ms. Kaupp), Syracuse, NY.

Background: Orthopaedic surgery is ever changing and depends on diverse technical and intellectual skill sets. The purpose of the current study was to evaluate the percentage of academic orthopaedic surgeons with additional graduate degrees in the United States.

Methods: Data including advanced degree(s) (eg, PhD, MS, MBA, MPH, JD, and DVM), academic rank, leadership position, subspecialty, years since training completion, and sex were collected from websites for all academic orthopaedic surgery departments in the United States.

View Article and Find Full Text PDF

Traumatic brain injury (TBI) is a major cause of long-term disability in young adults. An evidence-based treatment for TBI recovery, especially in the chronic phase, is not yet available. Using a severe TBI mouse model, we demonstrate that the neurorestorative efficacy of repeated treatments with stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF + G-CSF) in the chronic phase is superior to SCF + G-CSF single treatment.

View Article and Find Full Text PDF

The development of brain metastases (BMs) in breast cancer (BC) patients remains a challenging complication. Current clinical practice guidelines recommend local treatment of BMs without changing systemic therapy (CST) in patients with stable extracranial disease. We retrospectively investigated the impact of CST (when applicable as per treating physician's discretion) following the diagnosis and management of oligometastatic (1-3) BMs in patients without extracranial metastases on the progression-free survival time (PFS), and overall survival (OS).

View Article and Find Full Text PDF

Variants of the Aggression-Related Gene in a Population Representative Birth Cohort Study: Aggressiveness, Personality, and Alcohol Use Disorder.

Front Psychiatry

November 2020

Division of Neuropsychopharmacology, Department of Psychology, Estonian Center of Behavioral and Health Sciences, University of Tartu, Tartu, Estonia.

Recently, , a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behavior. Several loci in the gene have been nominally associated with aggression in genome-wide association studies, the risk alleles being more frequent in the general population. We have hence examined the association of four single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples.

View Article and Find Full Text PDF

Long-term beneficial effects of hematopoietic growth factors on brain repair in the chronic phase of severe traumatic brain injury.

Exp Neurol

August 2020

Department of Neurosurgery, The State University of New York Upstate Medical University, Syracuse, NY 13210, USA; VA Health Care Upstate New York, Syracuse VA Medical Center, USA. Electronic address:

Severe traumatic brain injury (TBI) is the major cause of long-term, even life-long disability and cognitive impairments in young adults. The lack of therapeutic approaches to improve recovery in the chronic phase of severe TBI is a big challenge to the medical research field. Using a single severe TBI model in young adult mice, this study examined the restorative efficacy of two hematopoietic growth factors, stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF), on brain repair in the chronic phase of TBI.

View Article and Find Full Text PDF

Objective: Weight change may be affected by dyadic processes within couple relationships. The aim of this secondary data analysis was to explore trends in BMI across time, and assess whether relationship processes (i.e.

View Article and Find Full Text PDF

Laboratory Evaluation of Spasmodic Dysphonia.

J Voice

November 2020

Department of Otolaryngology - Head & Neck Surgery, Senior Associate Dean, Drexel University College of Medicine, Philadelphia, Pennsylvania. Electronic address:

Objectives: To evaluate the utility of comprehensive laboratory evaluation in patients with spasmodic dysphonia (SD).

Study Design: Retrospective chart review.

Methods: A review of the medical records of 40 patients diagnosed with spasmodic dysphonia from 2009-2018 was preformed to evaluate abnormal test results that were significant when compared with abnormal results of the general population and for any other clinically relevant pathology.

View Article and Find Full Text PDF

Magnesium Sulfate and Novel Therapies to Promote Neuroprotection.

Clin Perinatol

June 2019

Department of Obstetrics and Gynecology, The State University of New York Upstate Medical University, 750 East Adams Street, 2204 Weiskotten Hall, Syracuse, NY 13210, USA; Department of Microbiology and Immunology, The State University of New York Upstate Medical University, 750 East Adams Street, 2204 Weiskotten Hall, Syracuse, NY 13210, USA. Electronic address:

Cerebral palsy occurs more often in preterm than in term deliveries and is one of the major neurologic injuries seen in preterm infants. Magnesium sulfate has been found to reduce the risk of cerebral palsy in patients at risk of delivery before 32 weeks' gestational age. Multiple large clinical trials have shown this effect.

View Article and Find Full Text PDF

Anterior lumbar interbody fusion (ALIF) is commonly utilized for surgical management of degenerative lumbar pathology. Although it is a reasonably safe procedure, it can potentially lead to major complications in case of neurovascular injuries. Occurrence of lymphocele after an ALIF is however rare.

View Article and Find Full Text PDF