5 results match your criteria: "The St. Laurent Institute[Affiliation]"
RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunction.
Front Cardiovasc Med
June 2024
Department of Medicine, Division of Genomic Medicine, The George Washington University, Washington, DC, United States.
Background: Ischemia with non-obstructive coronary arteries (INOCA) is a major clinical entity that involves potentially 20%-30% of patients with chest pain. INOCA is typically attributed either to coronary microvascular disease and/or vasospasm, but is likely distinct from classical coronary artery disease (CAD).
Objectives: To gain insights into the etiology of INOCA and CAD, RNA sequencing of whole blood from patients undergoing both stress testing and elective invasive coronary angiography (ICA) was conducted.
RNAseq profiling of blood from patients with coronary artery disease: Signature of a T cell imbalance.
J Mol Cell Cardiol Plus
June 2023
The St. Laurent Institute, 317 New Boston Street, Woburn, MA 01801, United States of America.
Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography either by invasive catheterization (ICA) or computed tomography (CTA).
View Article and Find Full Text PDFRNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model.
BMC Genomics
November 2021
Department of Medicine, Division of Genomic Medicine, The George Washington University Medical Center, 2300 Eye St, Washington D.C, 20037, USA.
Background: Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome effects of Traumeel (Tr14), a multicomponent natural product, and diclofenac, a non-selective cyclooxygenase (COX) inhibitor, were compared in a mouse cutaneous wound healing model to identify both known and novel pathways for the anti-inflammatory effect of plant-derived natural products.
Methods: Skin samples from abraded mice were analyzed by single-molecule, amplification-free RNAseq transcript profiling at 7 points between 12 and 192 h after injury.
RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.
BMC Med Genomics
September 2021
The St. Laurent Institute, Vancouver, WA, USA.
Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography.
View Article and Find Full Text PDFBiomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts.
BMC Med Genomics
October 2020
Oregon Health and Science University, Portland, OR, USA.
Article Synopsis
- Researchers explored the link between genetic markers and RNA gene expression in ADHD, utilizing advanced RNA sequencing methods on blood samples from twins and adolescents.* -
- By comparing data from discordant twins and case-controlled ADHD subjects, they identified specific RNA markers that are potential indicators of ADHD.* -
- The findings highlight genes previously linked to ADHD and suggest that combining DNA, RNA, and metabolic data could lead to new diagnostic tools and treatments.*