Design of intelligent human-machine collaborative robot-assisted craniotomy system.

Objectives: To develop an intelligent human-machine collaborative control robot-assisted craniotomy system, and test its efficacy by experiments.

Methods: The system integrated a UR5 robotic arm (Universal Robots, Denmark), a host computer, a double six-degree-of-freedom force sensor(Nanjing Yuli Instrument Co., Ltd.

Malignant melanoma: An important differential diagnosis for clear cell sarcoma of the gastrointestinal tract.

A case report by Liu describes the characteristics of metastatic clear cell sarcoma (CCS) of the pancreas and provides valuable therapeutic insights for this rare malignancy. This case is interesting because of its rarity, suggesting that the pancreas may be a potential target organ for CCS, either primary or metastatic. At the same time, the authors also emphasize the importance of regular postoperative follow-up for timely detection of recurrent lesions, as CCS is characterized by a high degree of malignancy and a high rate of recurrent metastases.

Incremental prognostic value of pericoronary adipose tissue attenuation beyond conventional features in patients with nonobstructive coronary artery disease.

Background And Aims: It remains uncertain whether pericoronary adipose tissue attenuation (PCATa) is associated with clinical outcome in patients with nonobstructive coronary artery disease (CAD). We aim to investigate the incremental prognostic value of PCATa beyond clinical and coronary computed tomographic angiography (CCTA) features in patients with nonobstructive CAD.

Methods: Consecutive patients with chest pain suspected of CAD referred for CCTA from January 2017 to December 2018 were prospectively included.

Sub-acute stroke demonstrates altered beta oscillation and connectivity pattern in working memory.

Introduction: Working memory (WM) is suggested to play a pivotal role in relearning and neural restoration during stroke rehabilitation. Using EEG, this study investigated the oscillatory mechanisms of WM in subacute stroke.

Methods: This study included 48 first subacute stroke patients (26 good-recovery, 22 poor-recovery, based on prognosis after a 4-week period) and 24 matched health controls.

Evaluating the efficacy of the SENO decision framework in managing metastatic spinal disease: a comparative study.

Background Context: The management of metastatic spinal disease presents a complex challenge, with no universally accepted guidelines currently available. A new treatment approach, termed the "SENO" (Systemic Conditions, Effectiveness of Systemic Treatment, Neurology, and Oncology) decision framework, was developed, incorporating a 12-point grading system for epidural spinal cord compression.

Purpose: This study aims to assess the clinical efficacy of the SENO decision framework and compare its outcomes with those from traditional treatment frameworks.

Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration.

Background: Intervertebral disc degeneration (IVDD) is a common cause of low back pain and spinal issues. Allogeneic platelet lysate (APL) is a blood product for several growth agents. However, only a few studies have revealed that APL can increase autophagy in defective mitochondria by activating the SIRT1-PINK1/parkin pathway while enhancing mitochondrial function to decrease reactive oxygen species (ROS) levels.

Effects of volatile anaesthetics on incidence of postoperative depression and anxiety symptoms in elderly patients: A retrospective analysis of a prospective cohort study.

Studies have suggested volatile anaesthetics may alleviate depression and anxiety symptoms in patients. However, there is a paucity of research in this area. We wanted to determine the association between volatile anaesthetics and depression/anxiety symptoms in elderly patients within 7 days after surgery.

A scoring model based on bacterial lipopolysaccharide-related genes to predict prognosis in NSCLC.

Background: Non-small cell lung cancer (NSCLC) has high incidence and mortality rates. The discovery of an effective biomarker for predicting prognosis and treatment response in patients with NSCLC is of great significance. Bacterial lipopolysaccharide-related genes (LRGs) play a critical role in tumor development and the formation of an immunosuppressive microenvironment; however, their relevance in NSCLC prognosis and immune features is yet to be discovered.

Application of intraoral scanning registration implant robot in dental implant surgery.

Objectives: This paper aims to investigate the application of intraoral scanning and cone beam computed tomography (CBCT) registration implant robot in dental implant surgery.

Methods: The data of 40 cases with dental defect of robot-assisted implantation from November 2023 to May 2024 were retrospectively analyzed. Before the operation, the intraoral scan data and CBCT data of the positioning markers were automatically fused with the initial CBCT images, and the registration error was calculated.

Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.

Background: Excessive oxidative stress is known to cause endothelial dysfunction and drive cardiovascular diseases (CVD). While telomerase reverse transcriptase (TERT) shows protective effects against oxidative stress in rodents and is associated to human flow-mediated dilation in CVD, its regulatory mechanisms in human vascular systems under pathological oxidative stress require further investigation.

Methods: Human induced pluripotent stem cells (hiPSCs) were used to create vascular organoids (VOs).

The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review.

Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular pathways by altering cell membrane potentials, leading to beneficial biological effects such as anti-inflammatory and neuroregenerative responses. This review compiles studies from PubMed up to March 2024, investigating the impact of light at wavelengths ranging from 620 to 1270 nm on ion channels. Out of 330 articles screened, 19 met the inclusion criteria.

Effects of Saccharomyces boulardii on microbiota composition and metabolite levels in the small intestine of constipated mice.

Saccharomyces boulardii (S. boulardii) is a fungal probiotic used to treat digestive disorders. However, the mechanism(s) by which S.

Banxia-Yiyiren alleviates insomnia and anxiety by regulating the gut microbiota and metabolites of PCPA-induced insomnia model rats.

Objective: This study aims to clearly define the effects of Banxia-Yiyiren on the gut microbiota and its metabolites in a para-chlorophenylalanine-induced insomnia model and the possible underlying mechanisms involved.

Materials And Methods: We employed 16S ribosomal ribonucleic acid (rRNA) gene sequencing combined with metabonomic analysis to explore the mutual effects of the PCPA-induced insomnia model and the gut microbiota and the intrinsic regulatory mechanism of Banxia-Yiyiren on the gut microbiota and metabolites in the PCPA-induced insomnia model.

Results: Banxia-Yiyiren was identified by mass spectrometry to include amino acids, small peptides, nucleotides, organic acids, flavonoids, fatty acids, lipids, and other main compound components.

The wound healing of deep partial-thickness burn in Bama miniature pigs is accelerated by a higher dose of hUCMSCs.

Background: Deep partial-thickness burns have a significant impact on both the physical and mental health of patients. Our previous study demonstrated human Umbilical Cord Mesenchymal stem cells (hUCMSCs) could enhance the healing of severe burns in small animal burn models, such as rats. Furthermore, our team has developed a deep partial-thickness burn model in Bama miniature pigs, which can be utilized for assessing drug efficacy in preclinical trials for wound healing.

Comparative Study and Transcriptomic Analysis on the Antifungal Mechanism of Ag Nanoparticles and Nanowires Against .

Background: Silver nanomaterials have been widely proven to have antifungal effects against . However, the antifungal mechanism of silver nanomaterials with different morphologies still needs to be explored.

Methods: Herein, the antifungal effect of silver nanomaterials against fungus was comparative investigated via silver nanowires and silver nanoparticles with a similar size (30 nm).

1-Year Clinical Outcomes and the Impact of Procedural Configurations in Left Atrial Appendage Occlusion Patients.

Background: The clinical performance of left atrial appendage occlusion (LAAO) as a procedure and the long-term impact of its varied implantation configurations and anticoagulation regimens remain unclear.

Objectives: This study sought to provide data in routine practice from a prospective multicenter registry.

Methods: A total of 3,096 consecutive patients from 39 Chinese centers undergoing LAAO were enrolled between April 1, 2019, and October 31, 2020.

Accuracy of prostigmin tests in the diagnosis of myasthenia gravis: a meta-analysis.

Myasthenia gravis (MG) is an acquired autoimmune disease diagnosed based on clinical manifestations, muscle fatigue tests, prostigmin tests, serum antibody tests, and neuroelectrophysiological examination. This study conducted a comprehensive search of PubMed, Web of Science, Scopus, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, WanFang, Chinese Periodical Database, Chinese Bio-Medicine Database, VIP, and DuXiu Database to identify relevant studies on the accuracy of prostigmin tests for diagnosing MG, covering publications from 1941 to 2021. Ten studies met the inclusion criteria and were included in the meta-analysis.