Biomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement.

Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used.

Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.

A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between normal and cancer cell counterparts. This opportunity can be explored as a novel treatment modality in Oncology.

Melt Electrowriting of Elastic Scaffolds Using PEOT-PBT Multi-block Copolymer.

Melt electrowriting (MEW) is a powerful additive manufacturing technique to produce tissue engineering scaffolds. Despite its strength, it is limited by a small number of processable polymers. Therefore, to broaden the library of materials for MEW, we investigated the printability of poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT-PBT), a thermoplastic elastomer.

Non-Equilibrium Quantum Brain Dynamics: Water Coupled with Phonons and Photons.

We investigate Quantum Electrodynamics (QED) of water coupled with sound and light, namely Quantum Brain Dynamics (QBD) of water, phonons and photons. We provide phonon degrees of freedom as additional quanta in the framework of QBD in this paper. We begin with the Lagrangian density QED with non-relativistic charged bosons, photons and phonons, and derive time-evolution equations of coherent fields and Kadanoff-Baym (KB) equations for incoherent particles.

Synthesis and Characterization of Novel 2-Alkyl-1,3,4-Oxadiazoles Containing a Phenylazo Group.

An efficient method for the synthesis of novel phenylazo-containing moieties is described. The derivatives of 5-(4-(phenyldiazenyl)phenyl)-1,3,4-oxadiazole, substituted at position 2 of the heterocyclic scaffold with alkyl groups of different chain lengths, were prepared. The titled compounds were obtained using the appropriate 4-(5-alkyl-1,3,4-oxadiazol-2-yl)anilines, which were directed to diazotization and subsequently coupled to phenol, resorcinol, and ,-dimethylaniline.

Removal of the cytostatic drugs bleomycin and vincristine by white-rot fungi under various conditions, and determination of enzymes involved, degradation by-products, and toxicity.

Anticancer drugs show recalcitrance to conventional wastewater treatments; thus, they are present in aquatic systems and pose an environmental threat. Fungi represent a promising biological alternative for wastewater treatments. Therefore, the goals of this work were to assess the potential of white-rot fungi (Fomes fomentarius (CB13), Hypholoma fasciculare (CB15), Phyllotopsis nidulans (CB14), Pleurotus ostreatus (BWPH), and Trametes versicolor (CB8)) for removing bleomycin and vincristine, and to investigate the impacts of various conditions (shaking, aeration, or biomass immobilization) on the process.

Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents.

Skin equivalents (SE) that recapitulate biological and mechanical characteristics of the native tissue are promising platforms for assessing cosmetics and studying fundamental biological processes. Methods to achieve SEs with well-organized structure, and ideal biological and mechanical properties are limited. Here, the combination of melt electrowritten PCL scaffolds and cell-laden Matrigel to fabricate SE is described.

MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities.

Breast cancer, a pervasive and complex disease, continues to pose significant challenges in the field of oncology. Its heterogeneous nature and diverse molecular profiles necessitate a nuanced understanding of the underlying mechanisms driving tumorigenesis and progression. MicroRNA-21 (miR-21) has emerged as a crucial player in breast cancer development and progression by modulating apoptosis, a programmed cell death mechanism that eliminates aberrant cells.

Design and Optimization of Molecularly Imprinted Polymer Targeting Epinephrine Molecule: A Theoretical Approach.

Molecularly imprinted polymers (MIPs) are a growing highlight in polymer chemistry. They are chemically and thermally stable, may be used in a variety of environments, and fulfill a wide range of applications. Computer-aided studies of MIPs often involve the use of computational techniques to design, analyze, and optimize the production of MIPs.

Pretreatment of Melanoma Cells with Aqueous Ethanol Extract from Bark Strongly Potentiates the Activity of a Low Dose of Dacarbazine.

is an evergreen tree distributed in India, Nepal, and Sri Lanka. This tree is commonly known as Mahua and is used in traditional medicine. It was demonstrated that ethanol extract from the bark of possessed potent cytotoxic activity towards two melanoma cell lines, in contrast to aqueous extract that exhibited no activity.

The Multifaceted Comparison of Effects of Immobilisation of Waste Imperial Smelting Furnace (ISF) Slag in Calcium Sulfoaluminates (CSA) and a Geopolymer Binder.

Using waste materials as replacements for sand in building materials helps reduce waste and improve the properties and sustainability of the construction materials. Authors proved the possibility of using imperial smelting furnace (ISF) slag granules as a 100% substitute for natural sand in self-compacting (SCC) cement-based mortars of calcium sulfoaluminates (CSA). The study proved that ISF slag's radioactive properties meet this area's requirements.

Quantum Brain Dynamics and Virtual Reality.

In this paper we propose a control theory of manipulating holograms in Quantum Brain Dynamics (QBD) involving our subjective experiences, i.e. qualia.

Study of the Myosin Relay Helix Peptide by Molecular Dynamics Simulations, Pump-Probe and 2D Infrared Spectroscopy.

The Davydov model was conjectured to describe how an amide I excitation created during ATP hydrolysis in myosin might be significant in providing energy to drive myosin's chemomechanical cycle. The free energy surfaces of the myosin relay helix peptide dissolved in 2,2,2-trifluoroethanol (TFE), determined by metadynamics simulations, demonstrate local minima differing in free energy by only ~2 kT, corresponding to broken and stabilized hydrogen bonds, respectively. Experimental pump-probe and 2D infrared spectroscopy were performed on the peptide dissolved in TFE.

Melt electrowritten poly-lactic acid /nanodiamond scaffolds towards wound-healing patches.

Multifunctional wound dressings, enriched with biologically active agents for preventing or treating infections and promoting wound healing, along with cell delivery capability, are highly needed. To address this issue, composite scaffolds with potential in wound dressing applications were fabricated in this study. The poly-lactic acid/nanodiamonds (PLA/ND) scaffolds were first printed using melt electrowriting (MEW) and then coated with quaternized β-chitin (QβC).

Novel Combretastatin A-4 Analogs-Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity.

Combretastatins isolated from the tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt the polymerization process of microtubules in tubulins, causing mitotic arrest. In vitro and in vivo studies have proven that some combretastatins exhibit antitumor properties, and among them, combretastatin A-4 is the most active mitotic inhibitor.

Measurement and Characterization of the Electrical Properties of Actin Filaments.

Actin filaments, as key components of the cytoskeleton, have aroused great interest due to their numerous functional roles in eukaryotic cells, including intracellular electrical signaling. The aim of this research is to characterize the alternating current (AC) conduction characteristics of both globular and polymerized actin and quantitatively compare their values to those theoretically predicted earlier. Actin filaments have been demonstrated to act as conducting bionanowires, forming a signaling network capable of transmitting ionic waves in cells.

Modeling non-genetic information dynamics in cells using reservoir computing.

Virtually all cells use energy-driven, ion-specific membrane pumps to maintain large transmembrane gradients of Na, K, Cl, Mg, and Ca, but the corresponding evolutionary benefit remains unclear. We propose that these gradients enable a dynamic and versatile biological system that acquires, analyzes, and responds to environmental information. We hypothesize that environmental signals are transmitted into the cell by ion fluxes along pre-existing gradients through gated ion-specific membrane channels.

Holographic Brain Theory: Super-Radiance, Memory Capacity and Control Theory.

We investigate Quantum Electrodynamics corresponding to the holographic brain theory introduced by Pribram to describe memory in the human brain. First, we derive a super-radiance solution in Quantum Electrodynamics with non-relativistic charged bosons (a model of molecular conformational states of water) for coherent light sources of holograms. Next, we estimate memory capacity of a brain neocortex, and adopt binary holograms to manipulate optical information.

Methoxychalcones as potential anticancer agents for colon cancer: Is membrane perturbing potency relevant?

Chalcones are naturally produced by many plants, and constitute precursors for the synthesis of flavons and flavanons. They were shown to possess antibacterial, antifungal, anti-cancer, and anti- inflammatory properties. The goal of the study was to assess the suitability of three synthetic methoxychalcones as potential anticancer agents.

The Effect of Mineral Wool Fiber Additive on Several Mechanical Properties and Thermal Conductivity in Geopolymer Binder.

The article discusses the effect of additives of waste mineral wool fibers on geopolymer binder. This is an important study in terms of the possibility of recycling mineral wool waste. The paper describes an effective method for pulverizing the wool and the methodology for forming geopolymer samples, labeled G1 for glass-wool-based geopolymer and G2 for stone-wool-based geopolymer.

An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin.

Volatile anesthetics (VAs) are medicinal chemistry compounds commonly used to enable surgical procedures for patients who undergo painful treatments and can be partially or fully sedated, remaining in an unconscious state during the operation. The specific molecular mechanism of anesthesia is still an open issue, but scientific evidence supports the hypothesis of the involvement of both putative hydrophobic cavities in membrane receptors as binding pockets and interactions between anesthetics and cytoplasmic proteins. Previous studies demonstrated the binding of VAs to tubulin.

Raw and Pre-Treated Styrene Butadiene Rubber (SBR) Dust as a Partial Replacement for Natural Sand in Mortars.

The circular economy (CE) is widely known for its emphasis on reducing waste and maximizing the use of resources by reusing, recycling, and repurposing materials to create a sustainable and efficient system. The CE is based on 3R-reuse, reduce, and recycle. The aim of this article is to use styrene butadiene rubber dust (SBR) in building material, constituting secondary waste in the production of SBR, which is currently disposed of as landfill.

Recycle Option for Municipal Solid Waste Incineration Fly Ash (MSWIFA) as a Partial Replacement for Cement in Mortars Containing Calcium Sulfoaluminate Cement (CSA) and Portland Cement to Save the Environment and Natural Resources.

Reduction of emissions, energy consumption, and use of substitutes for natural resources is an element of sustainable development and the circular economy. Cement production is a process with a high carbon footprint; therefore, minimizing the use of this material has a significant impact on reducing environmental costs. A substitute for cement is municipal solid waste incineration fly ash (MSWIFA).

A Systematic Evaluation of Feature Encoding Techniques for Gait Analysis Using Multimodal Sensory Data.

This paper addresses the problem of feature encoding for gait analysis using multimodal time series sensory data. In recent years, the dramatic increase in the use of numerous sensors, e.g.

Toward a holographic brain paradigm: a lipid-centric model of brain functioning.

Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that these dipole oscillations satisfy the weak Bose-Einstein condensate criteria of the Froehlich model of biological coherence. They can subsequently generate electromagnetic fields (EMFs) propagating in the inter-neuronal space.