257 results match your criteria: "The Seventh Medical Center of PLA General Hospital[Affiliation]"

Imaging analysis of ocular involvement in granulomatosis with polyangiitis.

Quant Imaging Med Surg

December 2024

Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

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Favorable outcomes and FDG-PET changes following tocilizumab treatment for febrile infection-related epilepsy syndrome in a child.

Int Immunopharmacol

December 2024

Department of Pediatrics, the First Medical Centre, Chinese PLA General Hospital, Beijing, China; Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China; Medical School of Chinese People's Liberation Army, Beijing, China. Electronic address:

Febrile Infection-Related Epilepsy Syndrome (FIRES) is an infrequent yet severe form of epilepsy that rapidly evolves into status epilepticus following a febrile episode. Prompt diagnosis coupled with effective treatment strategies is critical for improving patient outcomes. Herein, we describe the case of an 11-year-old male with FIRES who was successfully treated with tocilizumab, resulting in no further seizures or residual disability.

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A high-quality fluorescence elimination dual-wavelength Raman method for biological detection and its application in cancer diagnosis.

Spectrochim Acta A Mol Biomol Spectrosc

November 2024

Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:

Article Synopsis
  • Raman-based methods are promising for in vivo biological detection but face challenges due to fluorescence interference in measurement accuracy.
  • This study introduces a dual-wavelength Raman method using two different lasers to improve Raman signal quality by eliminating fluorescence effects.
  • The method was successfully applied to early cancer diagnosis, identifying significant biomolecules in esophageal tissue that indicate different malignancy levels.
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  • This study investigates the relationship between changes in microbial communities in the lungs and gut of a rat model for idiopathic pulmonary fibrosis (IPF) to understand how these changes may relate to disease mechanisms.
  • Researchers found significant differences in microbial composition in the lung and gut of IPF model rats when compared to control rats, indicating a potential link between microbial shifts and IPF.
  • Mediation analysis identified specific physiological indices, such as hydroxyproline and mean corpuscular volume, that connect lung and gut microbial genera, revealing complex interactions that could contribute to IPF pathology through the "gut-lung axis."
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  • - Bronchopulmonary dysplasia (BPD) commonly affects preterm infants and is linked to halted alveolar growth, with epithelial-mesenchymal transition (EMT) of AECII cells playing a crucial role in its development.
  • - The study found a significant reduction of WHAMM protein in mice with hyperoxia-induced BPD, suggesting that WHAMM helps prevent BPD progression by inhibiting EMT in AECIIs.
  • - WHAMM appears to aid in the autophagic degradation of TGF-β1, a factor that contributes to BPD, indicating that targeting the WHAMM/autophagy/TGF-β1/EMT pathway might provide new treatment options for
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Background: Silver nanomaterials have been widely proven to have antifungal effects against . However, the antifungal mechanism of silver nanomaterials with different morphologies still needs to be explored.

Methods: Herein, the antifungal effect of silver nanomaterials against fungus was comparative investigated via silver nanowires and silver nanoparticles with a similar size (30 nm).

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The dysregulation of circular RNAs (circRNAs) has been associated with OC development and progression. This study investigated the role of circZNF609 in ovarian cancer (OC) by analyzing its impact on cell proliferation, migration, and invasion. Initially, the study assessed the expression of circZNF609 in OC tissues and adjacent normal tissues.

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Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.

J Adv Res

October 2024

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University. Electronic address:

Introduction: Decreased periodontal ligament stem cells (PDLSCs) stemness is a key factor in age-related alveolar bone loss. Endoplasmic reticulum (ER) stress is closely related to age-related diseases and the mesenchymal stem cell (MSC) stemness. However, the role of ER stress in regulating the stemness of senescent PDLSCs and its potential mechanism remain unclear.

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The effect of COVID-19 vaccination on symptomatic infection and related symptoms among preterm-born children aged 3-7 years in China.

Sci Rep

October 2024

Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, 100010, China.

Article Synopsis
  • Vaccination is key in preventing SARS-CoV-2 infections, especially in vulnerable preterm-born children, but there is a lack of research on its effectiveness in this group.
  • A study involving 242 preterm-born children aged 3-7 years in China examined the impact of two inactivated vaccines (BBIBP-CorV and CoronaVac) after COVID-19 control measures were relaxed.
  • Results indicated that vaccination significantly reduced the risk of symptomatic COVID-19 and related complications like pneumonia, fever, and persistent symptoms in these children.
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Multimodal investigation of dynamic brain network alterations in autism spectrum disorder: Linking connectivity dynamics to symptoms and developmental trajectories.

Neuroimage

November 2024

Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macau S.A.R., China; Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau S.A.R., China. Electronic address:

Background: Autism spectrum disorder (ASD) has been associated with disrupted brain connectivity, yet a comprehensive understanding of the dynamic neural underpinnings remains lacking. This study employed concurrent electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) techniques to investigate dynamic functional connectivity (dFC) patterns and neurovascular characteristics in children with ASD. We also explored associations between neurovascular characteristics and the developmental trajectory of adaptive behavior in individuals with ASD.

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Background: Autism spectrum disorder (ASD) poses a significant challenge due to its diverse impact on individuals, emphasizing the need for personalized treatment plans. The financial burden of ASD-related healthcare is substantial, necessitating a comprehensive understanding of its prevalence and evolving trends.

Methods: This study aims to analyze the prevalence and trends of ASD, treatment patterns, gender differences, and racial-ethnic disparities in the United States from 2017 to 2020, utilizing nationally representative data from the National Survey of Children's Health (NSCH).

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N1-methyladenosine (mA) is a reversible epigenetic modification of RNAs. Aberrant mA modification levels due to dysregulation of mA regulators have been observed in multiple cancers. tRNA methyltransferase 10C (TRMT10C) can install mA in RNAs; however, its role in hepatoblastoma remains unknown.

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Objective: To analyze the predictive effect of preoperative peripheral blood leukocyte related inflammatory indicators on the prognosis of patients with serous papillary ovarian adenocarcinoma.

Methods: A retrospective analysis was conducted on the case data of 83 patients with ovarian cancer undergoing tumor cell reduction surgery admitted to our hospital from January 2017 to December 2020. Pathological findings confirmed serous papillary ovarian adenocarcinoma.

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Background: Surgery is an important treatment modality for patients with digestive system tumors, and perioperative management is crucial for the patients' recovery and quality of life. During the perioperative period, significant changes can occur in the oral environment of patients, such as dry mouth, mucosal ulceration, and oral infections. These issues not only cause discomfort to the patients but may also affect postoperative recovery and treatment outcomes.

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Article Synopsis
  • The study focuses on a type of fungus that normally lives on human skin but can cause deadly infections, exploring how it changes over time during chronic infections.
  • Two strains of this fungus were collected from a patient over a 15-year period to analyze microevolutionary changes using various methods, including immune response tests and gene expression analysis.
  • Results showed that the later strain of fungus caused less immune response and had altered gene activity, suggesting it became less harmful over time, allowing it to coexist more easily with the host.
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Objective: Exploring the predictive value of NLR, PLR, MLR, and SII for the severity of cervical cancer screening abnormalities in patients.

Methods: A retrospective analysis was conducted on the data of 324 patients suspected of cervical lesions due to abnormal TCT and/or HPV in our hospital from January 2023 to December 2023, who underwent colposcopy. The pathological results of colposcopic biopsy confirmed that there were 140 cases of chronic cervicitis, which classified as the group without cervical lesions.

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Alternative splicing (AS) is a universal phenomenon in eukaryotes, and it is still challenging to identify AS events. Several methods have been developed to identify AS events, such as expressed sequence tags (EST), microarrays and RNA-seq. However, EST has limitations in identifying low-abundance genes, while microarray and RNA-seq are high-throughput technologies, and PCR-based technology is needed for validation.

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GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.

Am J Hum Genet

July 2024

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China International Neuroscience Institute, National Center for Neurological Disorders, Beijing, China; Department of Neurosurgery, Xiongan Xuanwu Hospital, Xiong'an New Area, China. Electronic address:

Article Synopsis
  • Extra-axial cavernous hemangiomas (ECHs) are vascular lesions primarily found in the spine and cavernous sinus, posing risks during removal due to their complex nature and unclear genetic basis.
  • Genetic analyses of 31 ECH tissue samples revealed that 77.4% had mutations in specific genes (GNA14, GNAQ, GJA4), which were linked to significant changes in various cellular pathways, particularly those involved in angiogenesis.
  • Treatment with rapamycin in a 14-year-old patient with a specific GNAQ mutation showed promising results, with reduced hemangiomas and improved strength, indicating potential for targeted therapy in ECH treatment.
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Opening SCID newborn screening for novel exon genetic variants through whole-exome sequencing in China.

Int Immunopharmacol

August 2024

Faculty of Pediatrics, the Chinese PLA General Hospital, Beijing, China; Institute of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China; National Engineering Laboratory for Birth defects prevention and Control of key technology, Beijing, China; Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China. Electronic address:

Background: Severe combined immunodeficiency (SCID) is the most fatal form of inherited primary immunodeficiency disease. Known molecular defect mutations occur in most children with SCID.

Methods: Herein, we report Adenosine Deaminase-SCID (ADA-SCID) using whole-exome sequencing (WES), explore exome mutational landscape and significance for 17 SCID samples, and verify the mutated exon genes using the Gene Expression Omnibus (GEO) datasets.

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Objective: Employing whole-exome sequencing (WES) technology to investigate the etiology of infantile epileptic spasm syndrome (IESS), and determining whether different etiologies exhibit phenotypic variations, while elucidating the potential associated factors, might improve short-term responses to first-line treatment.

Methods: We retrospectively evaluated patients with IESS admitted for treatment between January 2018 and June 2023. Clinical phenotypic differences among etiological classifications and clinical manifestations were analyzed.

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Prognostic impact of tumor size in ureteral cancer following segmental ureterectomy.

Urol Oncol

November 2024

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To evaluate the classification and prognostic effects of a 2 cm tumor size in patients with ureteral cancer (UC) undergoing segmental ureterectomy (SU).

Patients And Methods: A total of 75 patients with UC who underwent SU in our hospital between April 2013 and April 2023 were included in this study. The study population was grouped based on tumor size, which was defined as the maximum diameter of the pathological specimens, resulting in 30 patients (40.

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Adequate bowel cleansing is crucial for endoscopic diagnosis and treatment, and the recovery of gut microbiota after intestinal cleansing is also important. A hypertonic syrup predominantly comprising L-arabinose and D-xylose (20% xylo-oligosaccharides) can be extracted from the hemicellulose of corn husks and cobs. L-Arabinose and xylo-oligosaccharides have been reported to relieve constipation and improve the gut microbial environment.

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Lower peripheral blood CD4 lymphocyte ratio is associated with severe bronchopulmonary dysplasia.

Pediatr Pulmonol

October 2024

Department of Neonatal Intensive Care Unit, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, China.

Objective: To elucidate the characteristics of lymphocyte subsets in bronchopulmonary dysplasia (BPD) diagnosis following Jensen's criterion to understand the spectrum of lymphocytes in different degrees of BPD.

Study Design: This single-center retrospective cohort study included 120 neonates admitted to the neonatal intensive care unit between 1 July 2014 and 30 June 2021, who had undergone peripheral blood lymphocyte subpopulation detection.

Results: Thirty-one neonates were included in the control group, whereas 33 infants with BPD were included in the case group.

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Corrigendum to "High-strength double-network silk fibroin based hydrogel loaded with icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair" [Biomater. Adv. volume 160 (2024) 213856].

Biomater Adv

July 2024

Savid School of Stomatology, Hangzhou Medical College, NO.8, Yikang Street, Hangzhou, Zhejiang 311399, China; Department of Implantology, Hangzhou Stomatology Hospital, NO.1, Pinghai Street, Hangzhou, Zhejiang 310000, China. Electronic address:

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Background: This study evaluates the outcomes of fibular intramedullary nails (IMNs) compared to traditional plates and screws (PS) in the surgical treatment of unstable ankle injuries in patients aged ≥65 years.

Method: We conducted a retrospective study involving 32 elderly patients with unstable ankle fractures treated with IMNs from 2010 to 2022. A comparison was made with 125 case-control patients treated with PS during the same period.

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